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A 1,000-year-old antimicrobial remedy with antistaphylococcal activity

Harrison, Freya; Roberts, Aled; Gabrilska, Rebecca; Rumbaugh, Kendra; Lee, Christina; Diggle, Stephen P.

Authors

Freya Harrison

Aled Roberts

Rebecca Gabrilska

Kendra Rumbaugh

Stephen P. Diggle steve.diggle@nottingham.ac.uk



Abstract

Plant-derived compounds and other natural substances are a rich potential source of compounds that kill or attenuate pathogens that are resistant to current antibiotics. Medieval so- cieties used a range of these natural substances to treat conditions clearly recognizable to the modern eye as microbial infections, and there has been much debate over the likely efficacy of these treatments. Our interdisciplinary team, comprising researchers from both sciences and humanities, identified and reconstructed a potential remedy for Staphylococcus aureus infection from a 10th Century Anglo-Saxon Leechbook. The remedy repeatedly killed established S. aureus biofilms in an in vitro model of soft tissue infection and killed methicillin-resistance S. aureus (MRSA) in a mouse chronic wound model. While the remedy contained several ingredients that are individually known to have some antibacterial activity, full efficacy required the combined action of several ingredients, highlighting the scholarship of pre-modern doctors and the potential of ancient texts as a source of new antimicrobial agents.

Journal Article Type Article
Publication Date Aug 11, 2015
Journal mBio
Electronic ISSN 2150-7511
Publisher American Society for Microbiology
Peer Reviewed Peer Reviewed
Volume 6
Issue 4
Article Number e01129
Pages 1-7
APA6 Citation Harrison, F., Roberts, A., Gabrilska, R., Rumbaugh, K., Lee, C., & Diggle, S. P. (2015). A 1,000-year-old antimicrobial remedy with antistaphylococcal activity. mBio, 6(4), (1-7). doi:10.1128/mBio.01129-15. ISSN 2150-7511
DOI https://doi.org/10.1128/mBio.01129-15
Publisher URL http://mbio.asm.org/content/6/4/e01129-15
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nd/4.0
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Copyright Statement
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nd/4.0





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