Freya Harrison
A 1,000-year-old antimicrobial remedy with antistaphylococcal activity
Harrison, Freya; Roberts, Aled; Gabrilska, Rebecca; Rumbaugh, Kendra; Lee, Christina; Diggle, Stephen P.
Authors
Aled Roberts
Rebecca Gabrilska
Kendra Rumbaugh
Dr CHRISTINA LEE christina.lee@nottingham.ac.uk
Associate Professor
Stephen P. Diggle steve.diggle@nottingham.ac.uk
Abstract
Plant-derived compounds and other natural substances are a rich potential source of compounds that kill or attenuate pathogens that are resistant to current antibiotics. Medieval so- cieties used a range of these natural substances to treat conditions clearly recognizable to the modern eye as microbial infections, and there has been much debate over the likely efficacy of these treatments. Our interdisciplinary team, comprising researchers from both sciences and humanities, identified and reconstructed a potential remedy for Staphylococcus aureus infection from a 10th Century Anglo-Saxon Leechbook. The remedy repeatedly killed established S. aureus biofilms in an in vitro model of soft tissue infection and killed methicillin-resistance S. aureus (MRSA) in a mouse chronic wound model. While the remedy contained several ingredients that are individually known to have some antibacterial activity, full efficacy required the combined action of several ingredients, highlighting the scholarship of pre-modern doctors and the potential of ancient texts as a source of new antimicrobial agents.
Journal Article Type | Article |
---|---|
Publication Date | Aug 11, 2015 |
Journal | mBio |
Electronic ISSN | 2150-7511 |
Publisher | American Society for Microbiology |
Peer Reviewed | Peer Reviewed |
Volume | 6 |
Issue | 4 |
Article Number | e01129 |
Pages | 1-7 |
APA6 Citation | Harrison, F., Roberts, A., Gabrilska, R., Rumbaugh, K., Lee, C., & Diggle, S. P. (2015). A 1,000-year-old antimicrobial remedy with antistaphylococcal activity. mBio, 6(4), (1-7). doi:10.1128/mBio.01129-15. ISSN 2150-7511 |
DOI | https://doi.org/10.1128/mBio.01129-15 |
Publisher URL | http://mbio.asm.org/content/6/4/e01129-15 |
Copyright Statement | Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nd/4.0 |
Additional Information | Composition Type: |
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A 1,000-Year-Old Antimicrobial Remedy with Antistaphylococcal Activity
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nd/4.0
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