The association between prior statin use and long-term outcomes after critical care admission

Beed, M.; Brindley, P.G.; Mahajan, R.; Juttner, I.; Campion-Smith, J.; Wilson, V.G.

doi:10.1016/j.jcrc.2016.04.031

The multidrug transporter ABCG2: still more questions than answers (2016)
Journal Article
Horsey, A. J., Cox, M. H., Sarwat, S., & Kerr, I. D. (2016). The multidrug transporter ABCG2: still more questions than answers. Biochemical Society Transactions, 44(3), 824-830. https://doi.org/10.1042/BST20160014

ABCG2 is one of at least three human ATP binding cassette (ABC) transporters which can facilitate the export from cells of a wide range of chemically unrelated drug molecules. This capacity for multidrug transport is not only a confounding factor in... Read More about The multidrug transporter ABCG2: still more questions than answers.

Systematic analysis of factors influencing observations of biased agonism at the mu-opioid receptor (2016)
Journal Article
Thompson, G., Lane, J., Coudrat, T., Sexton, P., Christopoulos, A., & Canals, M. (2016). Systematic analysis of factors influencing observations of biased agonism at the mu-opioid receptor. Biochemical Pharmacology, 113, 70-87. https://doi.org/10.1016/j.bcp.2016.05.014

Biased agonism describes the ability of distinct G protein-coupled receptor (GPCR) ligands to stabilise distinct receptor conformations leading to the activation of different cell signalling pathways that can deliver different physiologic outcomes. T... Read More about Systematic analysis of factors influencing observations of biased agonism at the mu-opioid receptor.

The Effect of Normobaric Hypoxic Confinement on Metabolism, Gut Hormones, and Body Composition (2016)
Journal Article
Mekjavic, I. B., Amon, M., Kölegård, R., Kounalakis, S. N., Simpson, L., Eiken, O., …Macdonald, I. A. (2016). The Effect of Normobaric Hypoxic Confinement on Metabolism, Gut Hormones, and Body Composition. Frontiers in Physiology, 7, Article 202. https://doi.org/10.3389/fphys.2016.00202

To assess the effect of normobaric hypoxia on metabolism, gut hormones, and body composition, 11 normal weight, aerobically trained (O2peak: 60.6 ± 9.5 ml·kg-1·min-1) men (73.0 ± 7.7 kg; 23.7 ± 4.0 years, BMI 22.2 ± 2.4 kg·m-2) were confined to a nor... Read More about The Effect of Normobaric Hypoxic Confinement on Metabolism, Gut Hormones, and Body Composition.

On the boundary layer structure near a highly permeable porous interface (2016)
Journal Article
Dalwadi, M. P., Chapman, S. J., Waters, S. L., & Oliver, J. M. (2016). On the boundary layer structure near a highly permeable porous interface. Journal of Fluid Mechanics, 798, 88-139. https://doi.org/10.1017/jfm.2016.308

The method of matched asymptotic expansions is used to study the canonical problem of steady laminar flow through a narrow two-dimensional channel blocked by a tight-fitting finite-length highly permeable porous obstacle. We investigate the behaviour... Read More about On the boundary layer structure near a highly permeable porous interface.

The N-terminus of survivin is a mitochondrial-targeting sequence and Src regulator (2016)
Journal Article
Dunajova, L., Cash, E., Markus, R., Rochette, S., Townley, A. R., & Wheatley, S. P. (in press). The N-terminus of survivin is a mitochondrial-targeting sequence and Src regulator. Journal of Cell Science, 129, https://doi.org/10.1242/jcs.183277

Survivin is a cancer-associated protein that exists in several locations in the cell. Its cytoplasmic residence in interphase cells is governed by CRM1-mediated nuclear exportation, and its localisation during mitosis to the centromeres and midzone m... Read More about The N-terminus of survivin is a mitochondrial-targeting sequence and Src regulator.

When genome-based approach meets the “Old but Good”: revealing genes involved in the antibacterial activity of Pseudomonas sp. P482 against soft rot pathogens (2016)
Journal Article
Krzyżanowska, D. M., Ossowicki, A., Rajewska, M., Maciąg, T., Jabłońska, M., Obuchowski, M., …Jafra, S. (2016). When genome-based approach meets the “Old but Good”: revealing genes involved in the antibacterial activity of Pseudomonas sp. P482 against soft rot pathogens. Frontiers in Microbiology, 7, Article 782. https://doi.org/10.3389/fmicb.2016.00782

Dickeya solani and Pectobacterium carotovorum subsp. brasiliense are recently established species of bacterial plant pathogens causing black leg and soft rot of many vegetables and ornamental plants. Pseudomonas sp. strain P482 inhibits the growth of... Read More about When genome-based approach meets the “Old but Good”: revealing genes involved in the antibacterial activity of Pseudomonas sp. P482 against soft rot pathogens.

Insights into CO2 fixation pathway of Clostridium autoethanogenumby targeted mutagenesis (2016)
Journal Article
Liew, F., Henstra, A. M., Winzer, K., Kopke, M., Simpson, S. D., & Minton, N. P. (in press). Insights into CO2 fixation pathway of Clostridium autoethanogenumby targeted mutagenesis. mBio, 7(3), Article e00427-16. https://doi.org/10.1128/mBio.00427-16

The future sustainable production of chemicals and fuels from nonpetrochemical resources and reduction of greenhouse gas emissions are two of the greatest societal challenges. Gas fermentation, which utilizes the ability of acetogenic bacteria such a... Read More about Insights into CO2 fixation pathway of Clostridium autoethanogenumby targeted mutagenesis.

A roadmap for gene system development in Clostridium (2016)
Journal Article
Minton, N. P., Ehsaan, M., Humphreys, C. M., Little, G. T., Baker, J., Henstra, A. M., …Zhang, Y. (2016). A roadmap for gene system development in Clostridium. Anaerobe, 41, 104-112. https://doi.org/10.1016/j.anaerobe.2016.05.011

Clostridium species are both heroes and villains. Some cause serious human and animal diseases, those present in the microbiota contribute to health and wellbeing, while others represent useful industrial chassis for the production of chemicals and f... Read More about A roadmap for gene system development in Clostridium.

Corticosterone and dopamine D2/D3 receptors mediate the motivation for voluntary wheel running in C57BL/6J mice (2016)
Journal Article
Ebada, M. E. E., Kendall, D. A., & Pardon, M.-C. (2016). Corticosterone and dopamine D2/D3 receptors mediate the motivation for voluntary wheel running in C57BL/6J mice. Behavioural Brain Research, 311, https://doi.org/10.1016/j.bbr.2016.05.051

Physical exercise can improve cognition but whether this is related to motivation levels is unknown. Voluntary wheel running is a rewarding activity proposed as a model of motivation to exercise. To question the potential effects of exercise motivati... Read More about Corticosterone and dopamine D2/D3 receptors mediate the motivation for voluntary wheel running in C57BL/6J mice.

CRISPR-based genome editing and expression control systems in Clostridium acetobutylicum and Clostridium beijerinckii (2016)
Journal Article

Solventogenic clostridia are important industrial microorganisms that produce various chemicals and fuels. Effective genetic tools would facilitate physiological studies aimed both at improving our understanding of metabolism and optimizing solvent p... Read More about CRISPR-based genome editing and expression control systems in Clostridium acetobutylicum and Clostridium beijerinckii.

Damage limitation (2016)
Journal Article
Amelio, I., & Melino, G. (2016). Damage limitation. eLife, 5, Article e17394. https://doi.org/10.7554/elife.17394

A spring-loaded mechanism can explain the activation process for a protein that has a crucial role in maintaining the genomic integrity of immature eggs cells.

Interrupting peptidoglycan deacetylation during Bdellovibrio predator-prey interaction prevents ultimate destruction of prey wall, liberating bacterial-ghosts (2016)
Journal Article
Lambert, C., Lerner, T. R., Bui, N. K., Somers, H., Aizawa, S., Liddell, S., …Sockett, R. E. (2016). Interrupting peptidoglycan deacetylation during Bdellovibrio predator-prey interaction prevents ultimate destruction of prey wall, liberating bacterial-ghosts. Scientific Reports, 6:26010(1), https://doi.org/10.1038/srep26010

The peptidoglycan wall, located in the periplasm between the inner and outer membranes of the cell envelope in Gram-negative bacteria, maintains cell shape and endows osmotic robustness. Predatory Bdellovibrio bacteria invade the periplasm of other b... Read More about Interrupting peptidoglycan deacetylation during Bdellovibrio predator-prey interaction prevents ultimate destruction of prey wall, liberating bacterial-ghosts.

Production of a functional cell wall-anchored minicellulosome by recombinant Clostridium acetobutylicum ATCC 824 (2016)
Journal Article
Willson, B. J., Kovács, K., Wilding-Steele, T., Markus, R., Winzer, K., & Minton, N. P. (2016). Production of a functional cell wall-anchored minicellulosome by recombinant Clostridium acetobutylicum ATCC 824. Biotechnology for Biofuels, 9(1), Article 109. https://doi.org/10.1186/s13068-016-0526-x

Background: The use of fossil fuels is no longer tenable. Not only are they a finite resource, their use is damaging the environment through pollution and global warming. Alternative, environmentally friendly, renewable sources of chemicals and fuels... Read More about Production of a functional cell wall-anchored minicellulosome by recombinant Clostridium acetobutylicum ATCC 824.

Cardiac troponin T is necessary for normal development in the embryonic chick heart (2016)
Journal Article
England, J., Pang, K. L., Parnall, M., Haig, M. I., & Loughna, S. (in press). Cardiac troponin T is necessary for normal development in the embryonic chick heart. Journal of Anatomy, https://doi.org/10.1111/joa.12486

The heart is the first functioning organ to develop during embryogenesis. The formation of the heart is a tightly regulated and complex process, and alterations to its development can result in congenital heart defects. Mutations in sarcomeric protei... Read More about Cardiac troponin T is necessary for normal development in the embryonic chick heart.

The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain (2016)
Journal Article
Xu, L., Nwosu, L. N., Burston, J., Millns, P., Sagar, D. R., Mapp, P. I., …Chapman, V. (2016). The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain. Osteoarthritis and Cartilage, 24(9), 1587-1595. https://doi.org/10.1016/j.joca.2016.05.015

Objective: Nerve growth factor (NGF) has a pivotal role in peripheral hyperalgesia and inflammation; anti-NGF antibodies attenuate pain responses in inflammatory pain models, and in people with osteoarthritis (OA) or low back pain. The aim of this st... Read More about The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain.

Immunomodulation with self-crosslinked polyelectrolyte multilayer-based coatings (2016)
Journal Article
Knopf-Marques, H., Singh, S., Htwe, S. S., Wolfova, L., Buffa, R., Bacharouche, J., …Lavalle, P. (2016). Immunomodulation with self-crosslinked polyelectrolyte multilayer-based coatings. Biomacromolecules, 17(6), 2189-2198. https://doi.org/10.1021/acs.biomac.6b00429

This study aims to design an optimal polyelectrolyte multilayer film of poly-L-lysine (PLL) and hyaluronic acid(HA) as an anti-inflammatory cytokine release system in order to decrease the implant failure due to any immune reactions. The chemical mod... Read More about Immunomodulation with self-crosslinked polyelectrolyte multilayer-based coatings.

Impaired burrowing is the most prominent behavioral deficit of aging htau mice (2016)
Journal Article
Geiszler, P. C., Barron, M., & Pardon, M.-C. (in press). Impaired burrowing is the most prominent behavioral deficit of aging htau mice. Neuroscience, https://doi.org/10.1016/j.neuroscience.2016.05.004

htau mice are deficient of murine tau but express all six human tau isoforms, leading to gradual tau misprocessing and aggregation in brain areas relevant to Alzheimer's disease. Whilst histopathological changes in htau mice have been researched in t... Read More about Impaired burrowing is the most prominent behavioral deficit of aging htau mice.

Non-parametric directionality analysis: extension for removal of a single common predictor and application to time series (2016)
Journal Article
Halliday, D. M., Senik, M. H., Stevenson, C. W., & Mason, R. (2016). Non-parametric directionality analysis: extension for removal of a single common predictor and application to time series. Journal of Neuroscience Methods, 268, https://doi.org/10.1016/j.jneumeth.2016.05.008

BACKGROUND: The ability to infer network structure from multivariate neuronal signals is central to computational neuroscience. Directed network analyses typically use parametric approaches based on auto-regressive (AR) models, where networks are con... Read More about Non-parametric directionality analysis: extension for removal of a single common predictor and application to time series.

Multivariable regression analysis in Schistosoma mansoni-infected individuals in the Sudan reveals unique immunoepidemiological profiles in uninfected, egg+ and non-egg+ infected individuals (2016)
Journal Article
Elfaki, T. E. M., Arndts, K., Wiszniewsky, A., Ritter, M., Goreish, I. A., Atti El Mekki, M. E. Y. A., …Layland, L. E. (2016). Multivariable regression analysis in Schistosoma mansoni-infected individuals in the Sudan reveals unique immunoepidemiological profiles in uninfected, egg+ and non-egg+ infected individuals. PLoS Neglected Tropical Diseases, 10(5), Article e0004629. https://doi.org/10.1371/journal.pntd.0004629

Background: In the Sudan, Schistosoma mansoni infections are a major cause of morbidity in schoolaged children and infection rates are associated with available clean water sources. During infection, immune responses pass through a Th1 followed by Th... Read More about Multivariable regression analysis in Schistosoma mansoni-infected individuals in the Sudan reveals unique immunoepidemiological profiles in uninfected, egg+ and non-egg+ infected individuals.

The association between prior statin use and long-term outcomes after critical care admission (2016)
Journal Article
Beed, M., Brindley, P., Mahajan, R., Juttner, I., Campion-Smith, J., & Wilson, V. (2016). The association between prior statin use and long-term outcomes after critical care admission. Journal of Critical Care, 35, 63-68. https://doi.org/10.1016/j.jcrc.2016.04.031

Background: Statins may have immunomodulatory effects that benefit critically ill patients. Therefore we retrospectively examined the association between survival and the prescription of statins prior to admission to an intensive care unit (ICU), or... Read More about The association between prior statin use and long-term outcomes after critical care admission.

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