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All Outputs (2211)

Assessing myxozoan presence and diversity using environmental DNA (2016)
Journal Article
Okamura, B., Hartikainen, H., Green, A. J., Bass, D., Knipe, H., & Briscoe, A. G. (2016). Assessing myxozoan presence and diversity using environmental DNA. International Journal for Parasitology, 46(12), 781-792. https://doi.org/10.1016/j.ijpara.2016.07.006

Amplicon sequencing on a High Throughput Sequencing platform (custom barcoding) was used to detect and characterise myxosporean communities in environmental DNA samples from marine and freshwater environments and in faeces of animals that may serve a... Read More about Assessing myxozoan presence and diversity using environmental DNA.

Phenological shifts in hoverflies (Diptera: Syrphidae): linking measurement and mechanism (2016)
Journal Article
Hassall, C., Owen, J., & Gilbert, F. (in press). Phenological shifts in hoverflies (Diptera: Syrphidae): linking measurement and mechanism. Ecography, 40(7), https://doi.org/10.1111/ecog.02623

An understanding of ecological and evolutionary responses to global environmental change requires both a robust measurement of the change that is occurring and a mechanistic framework for understanding the drivers of that change. Such a requirement p... Read More about Phenological shifts in hoverflies (Diptera: Syrphidae): linking measurement and mechanism.

Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models (2016)
Journal Article
Meesawatsom, P., Burston, J., Hathway, G., Bennett, A., & Chapman, V. (2016). Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models. Journal of Neuroinflammation, 13, Article 233. https://doi.org/10.1186/s12974-016-0676-6

Background Harnessing the actions of the resolvin pathways has the potential for the treatment of a wide range of conditions associated with overt inflammatory signalling. Aspirin-triggered resolvin D1 (AT-RvD1) has robust analgesic effects in behav... Read More about Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models.

Novel functional hepatitis C virus glycoprotein isolates identified using an optimized viral pseudotype entry assay (2016)
Journal Article
Urbanowicz, R. A., McClure, C. P., King, B., Mason, C. P., Ball, J. K., & Tarr, A. W. (2016). Novel functional hepatitis C virus glycoprotein isolates identified using an optimized viral pseudotype entry assay. Journal of General Virology, 97(9), 2265-2279. https://doi.org/10.1099/jgv.0.000537

Retrovirus pseudotypes are a highly tractable model used to study the entry pathways of enveloped viruses. This model has been extensively applied to the study of the hepatitis C virus (HCV) entry pathway, pre-clinical screening of antiviral antibodi... Read More about Novel functional hepatitis C virus glycoprotein isolates identified using an optimized viral pseudotype entry assay.

Longitudinal in vivo MRI in a Huntington’s disease mouse model: Global atrophy in the absence of white matter microstructural damage (2016)
Journal Article
Steventon, J. J., Trueman, R. C., Ma, D., Yhnell, E., Bayram-Weston, Z., Modat, M., …Jones, D. K. (2016). Longitudinal in vivo MRI in a Huntington’s disease mouse model: Global atrophy in the absence of white matter microstructural damage. Scientific Reports, 6(1), 1-12. https://doi.org/10.1038/srep32423

Huntington’s disease (HD) is a genetically-determined neurodegenerative disease. Characterising neuropathology in mouse models of HD is commonly restricted to cross-sectional ex vivo analyses, beset by tissue fixation issues. In vivo longitudinal mag... Read More about Longitudinal in vivo MRI in a Huntington’s disease mouse model: Global atrophy in the absence of white matter microstructural damage.

Periaqueductal grey EP3 receptors facilitate spinal nociception in arthritic secondary hypersensitivity (2016)
Journal Article
Drake, R. A., Leith, J., Almahasneh, F., Martindale, J., Wilson, A., Lumb, B., & Donaldson, L. F. (2016). Periaqueductal grey EP3 receptors facilitate spinal nociception in arthritic secondary hypersensitivity. Journal of Neuroscience, 36(35), https://doi.org/10.1523/JNEUROSCI.4393-15.2016

Descending controls on spinal nociceptive processing play a pivotal role in shaping the pain experience following tissue injury. Secondary hypersensitivity develops within undamaged tissue adjacent, and distant to, damaged sites. Spinal neuronal pool... Read More about Periaqueductal grey EP3 receptors facilitate spinal nociception in arthritic secondary hypersensitivity.

Beneficial effect of high energy intake at lunch rather than dinner on weight loss in healthy obese women in a weight-loss program: a randomized clinical trial (2016)
Journal Article
Madjd, A., Taylor, M. A., Delavari, A., Malekzadeh, R., MacDonald, I. A., & Farshchi, H. R. (2016). Beneficial effect of high energy intake at lunch rather than dinner on weight loss in healthy obese women in a weight-loss program: a randomized clinical trial. American Journal of Clinical Nutrition, 104(4), https://doi.org/10.3945/ajcn.116.134163

ABSTRACT Background: The association between the time of nutrient intake and health has been described in a few studies. To our knowledge, no study has evaluated the relation between high energy intakes at lunch compared with at dinner on weight los... Read More about Beneficial effect of high energy intake at lunch rather than dinner on weight loss in healthy obese women in a weight-loss program: a randomized clinical trial.

Application of Targeted Molecular and Material Property Optimization to Bacterial Attachment-Resistant (Meth)acrylate Polymers (2016)
Journal Article
Adlington, K., Nguyen, N. T., Eaves, E., Yang, J., Chang, C. Y., Li, J., …Irvine, D. J. (2016). Application of Targeted Molecular and Material Property Optimization to Bacterial Attachment-Resistant (Meth)acrylate Polymers. Biomacromolecules, 17(9), 2830-2838. https://doi.org/10.1021/acs.biomac.6b00615

© 2016 American Chemical Society. Developing medical devices that resist bacterial attachment and subsequent biofilm formation is highly desirable. In this paper, we report the optimization of the molecular structure and thus material properties of a... Read More about Application of Targeted Molecular and Material Property Optimization to Bacterial Attachment-Resistant (Meth)acrylate Polymers.

Expression and regulation of immune-modulatory enzyme Indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation (2016)
Journal Article
Aldajani, W. A., Salazar, F., Sewell, H. F., Knox, A., & Ghaemmaghami, A. M. (2016). Expression and regulation of immune-modulatory enzyme Indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation. Oncotarget, 7(36), https://doi.org/10.18632/oncotarget.11586

Indoleamine 2,3-dioxygenase (IDO) catalyzes the degradation of tryptophan, which plays a critical role in immune suppression through regulating the production of a series of metabolites that are generally referred to as kynurenines. It has become inc... Read More about Expression and regulation of immune-modulatory enzyme Indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation.

Coinfection and Emergence of Rifamycin Resistance during a Recurrent Clostridium difficile Infection (2016)
Journal Article
Stevenson, E. C., Major, G. A., Spiller, R. C., Kuehne, S. A., & Minton, N. P. (2016). Coinfection and Emergence of Rifamycin Resistance during a Recurrent Clostridium difficile Infection. Journal of Clinical Microbiology, 54(11), 2689-2694. https://doi.org/10.1128/jcm.01025-16

Clostridium difficile (Peptoclostridium difficile) is a common health care-associated infection with a disproportionately high incidence in elderly patients. Disease symptoms range from mild diarrhea to life-threatening pseudomembranous colitis. Arou... Read More about Coinfection and Emergence of Rifamycin Resistance during a Recurrent Clostridium difficile Infection.

Expression of polycomb protein BMI-1 1 maintains the plasticity of basal 2 bronchial epithelial cells (2016)
Journal Article
Torr, E., Heath, M., Mee, M., Shaw, D. E., Sharp, T. V., & Sayers, I. (2016). Expression of polycomb protein BMI-1 1 maintains the plasticity of basal 2 bronchial epithelial cells. Physiological Reports, 4(16), 1-14. https://doi.org/10.14814/phy2.12847

The airway epithelium is altered in respiratory disease and is thought to contribute to disease aetiology. A caveat to disease research is that the technique of isolation of bronchial epithelial cells from patients is invasive and cells have a limite... Read More about Expression of polycomb protein BMI-1 1 maintains the plasticity of basal 2 bronchial epithelial cells.

Hippocampal neural disinhibition causes attentional and memory deficits (2016)
Journal Article
McGarrity, S., Mason, R., Fone, K. C., Pezze, M. A., & Bast, T. (2017). Hippocampal neural disinhibition causes attentional and memory deficits. Cerebral Cortex, 27(9), https://doi.org/10.1093/cercor/bhw247

Subconvulsive hippocampal neural disinhibition, that is reduced GABAergic inhibition, has been implicated in neuropsychiatric disorders characterized by attentional and memory deficits, including schizophrenia and age-related cognitive decline. Consi... Read More about Hippocampal neural disinhibition causes attentional and memory deficits.

Mechanism of O2 diffusion and reduction in FeFe hydrogenases (2016)
Journal Article
Kubas, A., Orain, C., De Sancho, D., Saujet, L., Sensi, M., Gauquelin, C., …Léger, C. (2017). Mechanism of O2 diffusion and reduction in FeFe hydrogenases. Nature Chemistry, 9(1), 88-95. https://doi.org/10.1038/nchem.2592

© 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. FeFe hydrogenases are the most efficient H2-producing enzymes. However, inactivation by O2 remains an obstacle that prevents them being used in many biotechnological d... Read More about Mechanism of O2 diffusion and reduction in FeFe hydrogenases.

ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling (2016)
Journal Article
Goode, A., Rea, S., Sultana, M., Shaw, B., Searle, M. S., & Layfield, R. (2016). ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling. Molecular and Cellular Neuroscience, 76, https://doi.org/10.1016/j.mcn.2016.08.004

The transcription factor Nrf2 and its repressor protein Keap1 play key roles in the regulation of antioxidant stress responses and both Keap1-Nrf2 signalling and oxidative stress have been implicated in the pathogenesis of the ALS-FTLD spectrum of ne... Read More about ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling.

Detection of modified forms of cytosine using sensitive immunohistochemistry (2016)
Journal Article
Abakir, A., Wheldon, L. M., Johnson, A. D., Laurent, P., & Ruzov, A. (in press). Detection of modified forms of cytosine using sensitive immunohistochemistry. Journal of Visualized Experiments, 114(e54416), https://doi.org/10.3791/54416

Methylation of cytosine bases (5-methylcytosine, 5mC) occurring in vertebrate genomes is usually associated with transcriptional silencing. 5-hydroxylmethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) are the recently discov... Read More about Detection of modified forms of cytosine using sensitive immunohistochemistry.

The invertebrate lysozyme effector ILYS-3 is systemically activated in response to danger signals and confers antimicrobial protection in C. elegans (2016)
Journal Article
Gravato-Nobre, M. J., Vaz, F., Filipe, S., Chalmers, R., & Hodgkin, J. (2016). The invertebrate lysozyme effector ILYS-3 is systemically activated in response to danger signals and confers antimicrobial protection in C. elegans. PLoS Pathogens, 12(8), Article e1005826. https://doi.org/10.1371/journal.ppat.1005826

Little is known about the relative contributions and importance of antibacterial effectors in the nematode C. elegans, despite extensive work on the innate immune responses in this organism. We report an investigation of the expression, function and... Read More about The invertebrate lysozyme effector ILYS-3 is systemically activated in response to danger signals and confers antimicrobial protection in C. elegans.

High resolution sequencing of hepatitis C virus reveals limited intra-hepatic compartmentalization in end-stage liver disease (2016)
Journal Article
Hedegaard, D. L., Tully, D. C., Rowe, I. A., Reynolds, G. M., Bean, D. J., Hu, K., …McKeating, J. A. (2017). High resolution sequencing of hepatitis C virus reveals limited intra-hepatic compartmentalization in end-stage liver disease. Journal of Hepatology, 66(1), 28-38. https://doi.org/10.1016/j.jhep.2016.07.048

Background & Aims The high replication and mutation rate of hepatitis C virus (HCV) results in a heterogeneous population of viral sequences in vivo. HCV replicates in the liver and infected hepatocytes occur as foci surrounded by uninfected cells... Read More about High resolution sequencing of hepatitis C virus reveals limited intra-hepatic compartmentalization in end-stage liver disease.

Identification of a Cyanine-dye labeled peptidic ligand for Y₁R and Y₄R, based upon the Neuropeptide Y C-terminal analogue, BVD-15 (2016)
Journal Article
Liu, M., Richardson, R. R., Mountford, S. J., Zhang, L., Tempone, M. H., Herzog, H., …Thompson, P. E. (2016). Identification of a Cyanine-dye labeled peptidic ligand for Y₁R and Y₄R, based upon the Neuropeptide Y C-terminal analogue, BVD-15. Bioconjugate Chemistry, 27(9), 2166-2175. https://doi.org/10.1021/acs.bioconjchem.6b00376

Traceable truncated Neuropeptide Y (NPY) analogues with Y₁ receptor (Y₁R) affinity and selectivity are highly desirable tools in studying receptor location, regulation, and biological functions. A range of fluorescently labeled analogues of a reporte... Read More about Identification of a Cyanine-dye labeled peptidic ligand for Y₁R and Y₄R, based upon the Neuropeptide Y C-terminal analogue, BVD-15.

Parasites contribute to ecologically dependent postmating isolation in the adaptive radiation of three-spined stickleback. (2016)
Journal Article
El Nagar, A., & MacColl, A. D. (2016). Parasites contribute to ecologically dependent postmating isolation in the adaptive radiation of three-spined stickleback. Proceedings of the Royal Society B: Biological Sciences, 283(1836), 1-7. https://doi.org/10.1098/rspb.2016.0691

Spatial variation in parasitic infections is common, and has the potential to drive population divergence and reproductive isolation of hosts. However, despite support from theory and model laboratory systems, not much strong evidence has been forthc... Read More about Parasites contribute to ecologically dependent postmating isolation in the adaptive radiation of three-spined stickleback..