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Transcriptomic responses of mixed cultures of ascomycete fungi to lignocellulose using dual RNA-seq reveal inter-species antagonism and limited beneficial effects on CAZyme expression (2017)
Journal Article
Daly, P., van Munster, J. M., Kokolski, M., Sang, F., Blythe, M. J., Malla, S., …Archer, D. B. (2017). Transcriptomic responses of mixed cultures of ascomycete fungi to lignocellulose using dual RNA-seq reveal inter-species antagonism and limited beneficial effects on CAZyme expression. Fungal Genetics and Biology, 102, https://doi.org/10.1016/j.fgb.2016.04.005

Gaining new knowledge through fungal monoculture responses to lignocellulose is a widely used approach that can lead to better cocktails for lignocellulose saccharification (the enzymatic release of sugars which are subsequently used to make biofuels... Read More about Transcriptomic responses of mixed cultures of ascomycete fungi to lignocellulose using dual RNA-seq reveal inter-species antagonism and limited beneficial effects on CAZyme expression.

RadB acts in homologous recombination in the archaeon Haloferax volcanii, consistent with a role as recombination mediator (2017)
Journal Article
Wardell, K., Haldenby, S., Jones, N., Liddell, S., Ngo, G. H., & Allers, T. (2017). RadB acts in homologous recombination in the archaeon Haloferax volcanii, consistent with a role as recombination mediator. DNA Repair, 55, https://doi.org/10.1016/j.dnarep.2017.04.005

Homologous recombination plays a central role in the repair of double-strand DNA breaks, the restart of stalled replication forks and the generation of genetic diversity. Regulation of recombination is essential since defects can lead to genome insta... Read More about RadB acts in homologous recombination in the archaeon Haloferax volcanii, consistent with a role as recombination mediator.

Unbiased analysis of the impact of micropatterned biomaterials on macrophage behaviour provides insights beyond pre-defined polarisation states (2017)
Journal Article
Singh, S., Awuah, D., Rostam, H., Emes, R., Kandola, N. K., Onion, D., …Ghaemmaghami, A. M. (in press). Unbiased analysis of the impact of micropatterned biomaterials on macrophage behaviour provides insights beyond pre-defined polarisation states. ACS Biomaterials Science and Engineering, https://doi.org/10.1021/acsbiomaterials.7b00104

Macrophages are master regulators of immune responses towards implanted biomaterials. The activation state adopted by macrophages in response to biomaterials determines their own phenotype and function as well as those of other resident and infiltrat... Read More about Unbiased analysis of the impact of micropatterned biomaterials on macrophage behaviour provides insights beyond pre-defined polarisation states.

Experimental and mathematical analysis of cAMP nanodomains (2017)
Journal Article
Lohse, C., Bock, A., Maiellaro, I., Hannawacker, A., Schad, L. R., Lohse, M. J., & Bauer, W. R. (2017). Experimental and mathematical analysis of cAMP nanodomains. PLoS ONE, 12(4), Article e0174856. https://doi.org/10.1371/journal.pone.0174856

In their role as second messengers, cyclic nucleotides such as cAMP have a variety of intracellular effects. These complex tasks demand a highly organized orchestration of spatially and temporally confined cAMP action which should be best achieved by... Read More about Experimental and mathematical analysis of cAMP nanodomains.

Environmental modification via a quorum sensing molecule influences the social landscape of siderophore production (2017)
Journal Article
Popat, R., Harrison, F., da Silva, A. C., Easton, S. A., McNally, L., Williams, P., & Diggle, S. P. (2017). Environmental modification via a quorum sensing molecule influences the social landscape of siderophore production. Proceedings of the Royal Society B: Biological Sciences, 284(1852), Article 20170200. https://doi.org/10.1098/rspb.2017.0200

Bacteria produce a wide variety of exoproducts that favourably modify their environment and increase their fitness. These are often termed ‘public goods’ because they are costly for individuals to produce and can be exploited by non-producers (‘cheat... Read More about Environmental modification via a quorum sensing molecule influences the social landscape of siderophore production.

Overactive Epidermal Growth Factor Receptor Signaling Leads to Increased Fibrosis after Severe Acute Respiratory Syndrome Coronavirus Infection (2017)
Journal Article
Frieman, M. B., Coleman, C. M., & Venkataraman, T. (2017). Overactive Epidermal Growth Factor Receptor Signaling Leads to Increased Fibrosis after Severe Acute Respiratory Syndrome Coronavirus Infection. Journal of Virology, 91(12), https://doi.org/10.1128/jvi.00182-17

© 2017 American Society for Microbiology. All Rights Reserved. Severe acute respiratory syndrome coronavirus (SARS-CoV) is a highly pathogenic respiratory virus that causes morbidity and mortality in humans. After infection with SARS-CoV, the acute l... Read More about Overactive Epidermal Growth Factor Receptor Signaling Leads to Increased Fibrosis after Severe Acute Respiratory Syndrome Coronavirus Infection.

Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease (2017)
Journal Article
Baker, J. G., Gardiner, S. M., Woolard, J., Fromont, C., Jadhav, G. P., Mistry, S. N., …Fischer, P. M. (2017). Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease. FASEB Journal, 31(7), 3150-3166. https://doi.org/10.1096/fj.201601305R

β-Blockers reduce mortality and improve symptoms in people with heart disease. However, current clinically available β-blockers have poor selectivity for the cardiac β1-adrenoceptor (AR) over the lung β2-AR. Unwanted β2-blockade risks causing life-th... Read More about Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease.

Effects of deer on woodland structure revealed through terrestrial laser scanning (2017)
Journal Article
Eichhorn, M. P., Ryding, J., Smith, M. J., Gil, R. M., Siriwardena, G. M., & Fuller, R. J. (2017). Effects of deer on woodland structure revealed through terrestrial laser scanning. Journal of Applied Ecology, 54(6), 1615-1626. https://doi.org/10.1111/1365-2664.12902

1. Terrestrial laser scanning (TLS) captures the three-dimensional structure of habitats. Compared to traditional methods of forest mensuration, it allows quantification of structure at increased resolution, and the derivation of novel metrics with w... Read More about Effects of deer on woodland structure revealed through terrestrial laser scanning.

Real-time measurement of the intracellular pH of yeast cells during glucose metabolism using ratiometric fluorescent nanosensors (2017)
Journal Article
Elsutohy, M. M., Chauhan, V. M., Markus, R., Kyyaly, M. A., Tendler, S. J., & Aylott, J. W. (2017). Real-time measurement of the intracellular pH of yeast cells during glucose metabolism using ratiometric fluorescent nanosensors. Nanoscale, 9(18), 5904-5911. https://doi.org/10.1039/c7nr00906b

Intracellular pH is a key parameter that influences many biochemical and metabolic pathways that can also be used as an indirect marker to monitor metabolic and intracellular processes. Herein, we utilise ratiometric fluorescent pH-sensitive nanosens... Read More about Real-time measurement of the intracellular pH of yeast cells during glucose metabolism using ratiometric fluorescent nanosensors.

p63 Adjusts Sugar Taste of Epidermal Layers (2017)
Journal Article
Amelio, I., Melino, G., & Candi, E. (2017). p63 Adjusts Sugar Taste of Epidermal Layers. Journal of Investigative Dermatology, 137(6), 1204-1206. https://doi.org/10.1016/j.jid.2017.02.967

p63 is a master regulator of epidermal biology, sustaining stemness and renewal capacity of the proliferating keratinocyte compartment. Hamanaka and Mutlu propose that p63 regulates the keratinocyte proliferation/differentiation switch by affecting t... Read More about p63 Adjusts Sugar Taste of Epidermal Layers.

Entry inhibition of HSV-1 and -2 protects mice from viral lethal challenge (2017)
Journal Article
Clementi, N., Criscuolo, E., Cappelletti, F., Quaranta, P., Pistello, M., Diotti, R. A., …Mancini, N. (2017). Entry inhibition of HSV-1 and -2 protects mice from viral lethal challenge. Antiviral Research, 143, https://doi.org/10.1016/j.antiviral.2017.03.028

The present study focused on inhibition of HSV-1 and -2 replication and pathogenesis in vitro and in vivo, through the selective targeting of the envelope glycoprotein D. Firstly, a human monoclonal antibody (Hu-mAb#33) was identified that could neut... Read More about Entry inhibition of HSV-1 and -2 protects mice from viral lethal challenge.

Real-time analysis of the binding of fluorescent VEGF165a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor complexes (2017)
Journal Article
Kilpatrick, L. E., Friedman-Ohana, R., Alcobia, D. C., Riching, K., Peach, C. J., Wheal, A. J., …Hill, S. J. (2017). Real-time analysis of the binding of fluorescent VEGF165a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor complexes. Biochemical Pharmacology, 136, 62-75. https://doi.org/10.1016/j.bcp.2017.04.006

© 2017 The Authors Vascular endothelial growth factor (VEGF) is an important mediator of angiogenesis. Here we have used a novel stoichiometric protein-labeling method to generate a fluorescent variant of VEGF (VEGF165a-TMR) labeled on a single cyste... Read More about Real-time analysis of the binding of fluorescent VEGF165a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor complexes.

Defining motility in the Staphylococci (2017)
Journal Article
Pollitt, E. J., & Diggle, S. P. (in press). Defining motility in the Staphylococci. Cellular and Molecular Life Sciences, 74(16), https://doi.org/10.1007/s00018-017-2507-z

The ability of bacteria to move is critical for their survival in diverse environments and multiple ways have evolved to achieve this. Two forms of motility have recently been described for Staphylococcus aureus, an organism previously considered to... Read More about Defining motility in the Staphylococci.

Climate change may drive cave spiders to extinction (2017)
Journal Article
Mammola, S., Goodacre, S. L., & Isaia, M. (2018). Climate change may drive cave spiders to extinction. Ecography, 41(1), 233-243. https://doi.org/10.1111/ecog.02902

Subterranean ecosystems present ideal opportunities to study mechanisms underlying responses to changes in climate because species within them are often adapted to a largely constant temperature. We have characterized the thermal conditions of caves... Read More about Climate change may drive cave spiders to extinction.

Intramyocellular lipid content and lipogenic gene expression responses following a single bout of resistance type exercise differ between young and older men (2017)
Journal Article
Tsintzas, K., Stephens, F. B., Snijders, T., Wall, B. T., Cooper, S., Mallinson, J., …van Loon, L. J. (2017). Intramyocellular lipid content and lipogenic gene expression responses following a single bout of resistance type exercise differ between young and older men. Experimental Gerontology, 93, https://doi.org/10.1016/j.exger.2017.03.018

The aim of this study was to examine the temporal relationship between intramyocellular lipid (IMCL) content and the expression of genes associated with IMCL turnover, fat metabolism, and inflammation during recovery from an acute bout of resistance... Read More about Intramyocellular lipid content and lipogenic gene expression responses following a single bout of resistance type exercise differ between young and older men.

Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduces mitochondrial ROS production (2017)
Journal Article
Meier, J. A., Hyun, M., Cantwell, M., Raza, A., Mertens, C., Raje, V., …Larner, A. C. (2017). Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduces mitochondrial ROS production. Science Signaling, 10(472), Article eaag2588. https://doi.org/10.1126/scisignal.aag2588

Signal Transducer and Activator of Transcription 3 (STAT3) has been tied to various physiological and pathological functions, mainly as a transcription factor that translocates to the nucleus upon tyrosine phosphorylation induced by cytokine stimulat... Read More about Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduces mitochondrial ROS production.

Why prokaryotes have pangenomes (2017)
Journal Article
McInerney, J. O., McNally, A., & O'Connell, M. J. (2017). Why prokaryotes have pangenomes. Nature Microbiology, 2(4), Article 17040. https://doi.org/10.1038/nmicrobiol.2017.40

The existence of large amounts of within-species genome content variability is puzzling. Population genetics tells us that fitness effects of new variants—either deleterious, neutral or advantageous—combined with the long-term effective population si... Read More about Why prokaryotes have pangenomes.

Tropomyosin 1: multiple roles in the developing heart and in the formation of congenital heart defects (2017)
Journal Article
England, J., Granados-Riveron, J. T., Polo-Parada, L., Kuriakose, D., Moore, C., Brook, J. D., …Loughna, S. (2017). Tropomyosin 1: multiple roles in the developing heart and in the formation of congenital heart defects. Journal of Molecular and Cellular Cardiology, 106, https://doi.org/10.1016/j.yjmcc.2017.03.006

Tropomyosin 1 (TPM1) is an essential sarcomeric component, stabilising the thin filament and facilitating actin's interaction with myosin. A number of sarcomeric proteins, such as alpha myosin heavy chain, play crucial roles in cardiac development. M... Read More about Tropomyosin 1: multiple roles in the developing heart and in the formation of congenital heart defects.