Skip to main content

Research Repository

Advanced Search

All Outputs (2229)

Modelled-Microgravity Reduces Virulence Factor Production in Staphylococcus aureus through Downregulation of agr-Dependent Quorum Sensing (2023)
Journal Article
Green, M. J., Murray, E. J., Williams, P., Ghaemmaghami, A. M., Aylott, J. W., & Williams, P. M. (2023). Modelled-Microgravity Reduces Virulence Factor Production in Staphylococcus aureus through Downregulation of agr-Dependent Quorum Sensing. International Journal of Molecular Sciences, 24(21), Article 15997. https://doi.org/10.3390/ijms242115997

Bacterial contamination during space missions is problematic for human health and damages filters and other vital support systems. Staphylococcus aureus is both a human commensal and an opportunistic pathogen that colonizes human tissues and causes a... Read More about Modelled-Microgravity Reduces Virulence Factor Production in Staphylococcus aureus through Downregulation of agr-Dependent Quorum Sensing.

The IUPHAR/BPS Guide to PHARMACOLOGY in 2024 (2023)
Journal Article
Harding, S. D., Armstrong, J. F., Faccenda, E., Southan, C., Alexander, S. H., Davenport, A. P., …Davies, J. A. (2024). The IUPHAR/BPS Guide to PHARMACOLOGY in 2024. Nucleic Acids Research, 52(D1), D1438-D1449. https://doi.org/10.1093/nar/gkad944

The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb; https://www.guidetopharmacology.org) is an open-access, expert-curated, online database that provides succinct overviews and key references for pharmacological targets and their recommended experimental l... Read More about The IUPHAR/BPS Guide to PHARMACOLOGY in 2024.

Bioactive and chemically defined hydrogels with tunable stiffness guide cerebral organoid formation and modulate multi-omics plasticity in cerebral organoids (2023)
Journal Article
Isik, M., Okesola, B. O., Eylem, C. C., Kocak, E., Nemutlu, E., D'Este, M., …Derkus, B. (2023). Bioactive and chemically defined hydrogels with tunable stiffness guide cerebral organoid formation and modulate multi-omics plasticity in cerebral organoids. Acta Biomaterialia, 171, 223-238. https://doi.org/10.1016/j.actbio.2023.09.040

Organoids are an emerging technology with great potential in human disease modelling, drug development, diagnosis, tissue engineering, and regenerative medicine. Organoids as 3D-tissue culture systems have gained special attention in the past decades... Read More about Bioactive and chemically defined hydrogels with tunable stiffness guide cerebral organoid formation and modulate multi-omics plasticity in cerebral organoids.

Spaceflight Induces Strength Decline in Caenorhabditis elegans (2023)
Journal Article
Soni, P., Edwards, H., Anupom, T., Rahman, M., Lesanpezeshki, L., Blawzdziewicz, J., …Vanapalli, S. A. (2023). Spaceflight Induces Strength Decline in Caenorhabditis elegans. Cells, 12(20), Article 2470. https://doi.org/10.3390/cells12202470

Background: Understanding and countering the well-established negative health consequences of spaceflight remains a primary challenge preventing safe deep space exploration. Targeted/personalized therapeutics are at the forefront of space medicine st... Read More about Spaceflight Induces Strength Decline in Caenorhabditis elegans.

RsaL-driven negative regulation promotes heterogeneity in Pseudomonas aeruginosa quorum sensing (2023)
Journal Article
Mellini, M., Letizia, M., Caruso, L., Guiducci, A., Meneghini, C., Heeb, S., Williams, P., Cámara, M., Visca, P., Imperi, F., Leoni, L., & Rampioni, G. (2023). RsaL-driven negative regulation promotes heterogeneity in Pseudomonas aeruginosa quorum sensing. mBio, 14(6), Article e02039-23. https://doi.org/10.1128/mbio.02039-23

In its canonical interpretation, quorum sensing (QS) allows single cells in a bacterial population to synchronize gene expression and hence perform specific tasks collectively once the quorum cell density is reached. However, growing evidence in diff... Read More about RsaL-driven negative regulation promotes heterogeneity in Pseudomonas aeruginosa quorum sensing.

Tetherin antagonism by SARS-CoV-2 ORF3a and spike protein enhances virus release (2023)
Journal Article
Stewart, H., Palmulli, R., Johansen, K. H., McGovern, N., Shehata, O. M., Carnell, G. W., …Edgar, J. R. (2023). Tetherin antagonism by SARS-CoV-2 ORF3a and spike protein enhances virus release. EMBO Reports, 24(12), Article e57224. https://doi.org/10.15252/embr.202357224

The antiviral restriction factor, tetherin, blocks the release of several different families of enveloped viruses, including the Coronaviridae. Tetherin is an interferon-induced protein that forms parallel homodimers between the host cell and viral p... Read More about Tetherin antagonism by SARS-CoV-2 ORF3a and spike protein enhances virus release.

Antibody-based sex determination of human skeletal remains (2023)
Journal Article
Shaw, B., Foggin, S., Hamilton-Stanley, P., Barlow, A., Pickard, C., Fibiger, L., …Layfield, R. (2023). Antibody-based sex determination of human skeletal remains. iScience, 26(11), Article 108191. https://doi.org/10.1016/j.isci.2023.108191

Assignment of biological sex to skeletal remains is critical in the accurate reconstruction of the past. Analysis of sex-chromosome encoded AMELX and AMELY peptides from the enamel protein amelogenin underpins a minimally destructive mass spectrometr... Read More about Antibody-based sex determination of human skeletal remains.

Reciprocal regulation of NagC and quorum sensing systems and their roles in hmsHFRS expression and biofilm formation in Yersinia pseudotuberculosis (2023)
Journal Article
Wiechmann, A., Garcia, V., Elton, L., Williams, P., & Atkinson, S. (2023). Reciprocal regulation of NagC and quorum sensing systems and their roles in hmsHFRS expression and biofilm formation in Yersinia pseudotuberculosis. Microbiology, 169(10), Article 001397. https://doi.org/10.1099/mic.0.001397

Biofilm formation by Yersinia pseudotuberculosis is regulated by quorum sensing (QS) and dependent on the haemin storage locus hms, required for the extracellular polysaccharide poly-N-acetylglucosamine (poly-GlcNAc) production. In Escherichia coli N... Read More about Reciprocal regulation of NagC and quorum sensing systems and their roles in hmsHFRS expression and biofilm formation in Yersinia pseudotuberculosis.

Cortical oxygen extraction fraction using quantitative BOLD MRI and cerebral blood flow during vasodilation (2023)
Journal Article
Le, L. N. N., Wheeler, G. J., Holy, E. N., Donnay, C. A., Blockley, N. P., Yee, A. H., …Fan, A. P. (2023). Cortical oxygen extraction fraction using quantitative BOLD MRI and cerebral blood flow during vasodilation. Frontiers in Physiology, 14, Article 1231793. https://doi.org/10.3389/fphys.2023.1231793

Introduction: We aimed to demonstrate non-invasive measurements of regional oxygen extraction fraction (OEF) from quantitative BOLD MRI modeling at baseline and after pharmacological vasodilation. We hypothesized that OEF decreases in response to vas... Read More about Cortical oxygen extraction fraction using quantitative BOLD MRI and cerebral blood flow during vasodilation.

Ultrasensitive PCR system for HBV DNA detection: Risk stratification for occult hepatitis B virus infection in English blood donors (2023)
Journal Article
Fu, M. X., Simmonds, P., Andreani, J., Baklan, H., Webster, M., Asadi, R., …Harvala, H. (2023). Ultrasensitive PCR system for HBV DNA detection: Risk stratification for occult hepatitis B virus infection in English blood donors. Journal of Medical Virology, 95(10), Article e29144. https://doi.org/10.1002/jmv.29144

Occult hepatitis B (HBV) infection (OBI), characterized by low viral loads, accounts for much of the risk of HBV transfusion-transmitted infection. With anticore antibodies (anti-HBc) screening introduced in England, the imperative to identify OBI do... Read More about Ultrasensitive PCR system for HBV DNA detection: Risk stratification for occult hepatitis B virus infection in English blood donors.

Protein dose requirements to maximise skeletal muscle protein synthesis after repeated bouts of resistance exercise in young trained women (2023)
Journal Article
MALLINSON, J., WARDLE, S., O'LEARY, T., GREEVES, J., CEGIELSKI, J., BASS, J., …GREENHAFF, P. (2023). Protein dose requirements to maximise skeletal muscle protein synthesis after repeated bouts of resistance exercise in young trained women. Scandinavian Journal of Medicine and Science in Sports, 33(12), 2470-2481. https://doi.org/10.1111/sms.14506

Studies examining the effect of protein (PRO) feeding on post resistance exercise (RE) muscle protein synthesis (MPS) have primarily been performed in men, and little evidence is available regarding the quantity of PRO required to maximally stimulate... Read More about Protein dose requirements to maximise skeletal muscle protein synthesis after repeated bouts of resistance exercise in young trained women.

Brain state transitions primarily impact the spontaneous rate of slow-firing neurons (2023)
Journal Article
Dearnley, B., Jones, M., Dervinis, M., & Okun, M. (2023). Brain state transitions primarily impact the spontaneous rate of slow-firing neurons. Cell Reports, 42(10), Article 113185. https://doi.org/10.1016/j.celrep.2023.113185

The spontaneous firing of neurons is modulated by brain state. Here, we examine how such modulation impacts the overall distribution of firing rates in neuronal populations of neocortical, hippocampal, and thalamic areas across natural and pharmacolo... Read More about Brain state transitions primarily impact the spontaneous rate of slow-firing neurons.

Fine mapping of the Cepaea nemoralis shell colour and mid-banded loci using a high-density linkage map (2023)
Journal Article
Johansen, M., Saenko, S., Schilthuizen, M., Berriman, M., Durbin, R., Lawniczak, M., …Davison, A. (2023). Fine mapping of the Cepaea nemoralis shell colour and mid-banded loci using a high-density linkage map. Heredity, https://doi.org/10.1038/s41437-023-00648-z

Molluscs are a highly speciose phylum that exhibits an astonishing array of colours and patterns, yet relatively little progress has been made in identifying the underlying genes that determine phenotypic variation. One prominent example is the land... Read More about Fine mapping of the Cepaea nemoralis shell colour and mid-banded loci using a high-density linkage map.

Antiviral activity of salt-coated materials against SARS-CoV-2 (2023)
Journal Article
Coleman, C. M., Wang, B., Wang, Y., Tapia-Brito, E., Chen, Z., Riffat, J., …Ghaemmaghami, A. (2023). Antiviral activity of salt-coated materials against SARS-CoV-2. Access Microbiology, 5(9), Article 000492. https://doi.org/10.1099/acmi.0.000492.v5

The SARS-CoV-2 pandemic demonstrated the importance of human coronaviruses and the need to develop materials to prevent the spread of emergent respiratory viruses. Coating of surfaces with antiviral materials is a major interest in controlling spread... Read More about Antiviral activity of salt-coated materials against SARS-CoV-2.

Dysregulation of RNA modification systems in clinical populations with neurocognitive disorders (2023)
Journal Article
KNIGHT, H., Öz, M. D., & PerezGrovas-Saltijeral, A. (2024). Dysregulation of RNA modification systems in clinical populations with neurocognitive disorders. Neural Regeneration Research, 19(6), 1256-1261. https://doi.org/10.4103/1673-5374.385858

The study of modified RNA known as epitranscriptomics has become increasingly relevant in our understanding of disease-modifying mechanisms. Methylation of N6 adenosine (m 6 A) and C5 cytosine (m 5 C) bases occur on mRNAs, tRNA, mt-tRNA, and rRNA spe... Read More about Dysregulation of RNA modification systems in clinical populations with neurocognitive disorders.

The human fungal pathogen Aspergillus fumigatus can produce the highest known number of meiotic crossovers (2023)
Journal Article
Auxier, B., Debets, A. J., Rhodes, J., Stanford, F. A., Becker, F. M., Marquez, F. R., …Snelders, E. (2023). The human fungal pathogen Aspergillus fumigatus can produce the highest known number of meiotic crossovers. PLoS Biology, 21(9), Article e3002278. https://doi.org/10.1371/journal.pbio.3002278

Sexual reproduction involving meiosis is essential in most eukaryotes. This produces offspring with novel genotypes, both by segregation of parental chromosomes as well as crossovers between homologous chromosomes. A sexual cycle for the opportunisti... Read More about The human fungal pathogen Aspergillus fumigatus can produce the highest known number of meiotic crossovers.

Post-Cancer Treatment Reflections by Patients Concerning the Provisions and Support Required for a Prehabilitation Programme (2023)
Journal Article
Jandu, A. K., Nitayamekin, A., Stevenson, J., Beed, M., Vohra, R. S., Wilson, V. G., & Lobo, D. N. (2023). Post-Cancer Treatment Reflections by Patients Concerning the Provisions and Support Required for a Prehabilitation Programme. World Journal of Surgery, 47(11), 2724-2732. https://doi.org/10.1007/s00268-023-07170-7

Background: Evidence suggests that physical fitness interventions, mental health support and nutritional advice before surgery (prehabilitation) could reduce hospital stay and improve quality of life of patients with cancer. In this study we captured... Read More about Post-Cancer Treatment Reflections by Patients Concerning the Provisions and Support Required for a Prehabilitation Programme.

Candidate signatures of positive selection for environmental adaptation in indigenous African cattle: A review (2023)
Journal Article
Kambal, S., Tijjani, A., Ibrahim, S. A., Ahmed, M. K. A., Mwacharo, J. M., & Hanotte, O. (in press). Candidate signatures of positive selection for environmental adaptation in indigenous African cattle: A review. Animal Genetics, https://doi.org/10.1111/age.13353

Environmental adaptation traits of indigenous African cattle are increasingly being investigated to respond to the need for sustainable livestock production in the context of unpredictable climatic changes. Several studies have highlighted genomic re... Read More about Candidate signatures of positive selection for environmental adaptation in indigenous African cattle: A review.

Osteological, multi-isotope and proteomic analysis of poorly-preserved human remains from a Dutch East India Company burial ground in South Africa (2023)
Journal Article
Olszewski, J., Hall, R. A., Kootker, L. M., Oldham, N. J., Layfield, R., Shaw, B., …Schrader, S. A. (2023). Osteological, multi-isotope and proteomic analysis of poorly-preserved human remains from a Dutch East India Company burial ground in South Africa. Scientific Reports, 13, Article 14666. https://doi.org/10.1038/s41598-023-41503-9

Skeletal remains discovered in Simon’s Town, South Africa, were hypothesised as being associated with a former Dutch East India Company (VOC) hospital. We report a novel combined osteological and biochemical approach to these poorly-preserved remains... Read More about Osteological, multi-isotope and proteomic analysis of poorly-preserved human remains from a Dutch East India Company burial ground in South Africa.