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Tissue transglutaminase treatment leads to concentration-dependent changes in dendritic cell phenotype - implications for the role of transglutaminase in coeliac disease (2012)
Journal Article
Dalleywater, W. J., Chau, D. Y., & Ghaemmaghami, A. M. (2012). Tissue transglutaminase treatment leads to concentration-dependent changes in dendritic cell phenotype - implications for the role of transglutaminase in coeliac disease. BMC Immunology, 13, Article 20. https://doi.org/10.1186/1471-2172-13-20

Dendritic cells (DCs) are part of the innate immune system with a key role in initiating and modulating T cell mediated immune responses. Coeliac disease is caused by inappropriate activation of such a response leading to small intestinal inflammatio... Read More about Tissue transglutaminase treatment leads to concentration-dependent changes in dendritic cell phenotype - implications for the role of transglutaminase in coeliac disease.

Cj1136 is required for lipooligosaccharide biosynthesis, hyperinvasion, and chick colonization by Campylobacter jejuni (2012)
Journal Article
Javed, M. A., Cawthraw, S. A., Baig, A., Li, J., McNally, A., Oldfield, N. J., …Manning, G. (2012). Cj1136 is required for lipooligosaccharide biosynthesis, hyperinvasion, and chick colonization by Campylobacter jejuni. Infection and Immunity, 80(7), 2361-2370. https://doi.org/10.1128/IAI.00151-12

Campylobacter jejuni is a major cause of bacterial food-borne enteritis worldwide, and invasion into intestinal epithelial cells is an important virulence mechanism. Recently we reported the identification of hyperinvasive C. jejuni strains and creat... Read More about Cj1136 is required for lipooligosaccharide biosynthesis, hyperinvasion, and chick colonization by Campylobacter jejuni.

Ecological partitioning and diversity in tropical planktonic foraminifera (2012)
Journal Article
Seears, H. A., Darling, K. F., & Wade, C. M. (2012). Ecological partitioning and diversity in tropical planktonic foraminifera. BMC Evolutionary Biology, 12, Article 54. https://doi.org/10.1186/1471-2148-12-54

Background: Ecological processes are increasingly being viewed as an important mode of diversification in the marine environment, where the high dispersal potential of pelagic organisms, and a lack of absolute barriers to gene flow may limit the occu... Read More about Ecological partitioning and diversity in tropical planktonic foraminifera.

Coupling of kinesin ATP turnover to translocation and microtubule regulation: One engine, many machines (2012)
Journal Article
Friel, C. T., & Howard, J. (2012). Coupling of kinesin ATP turnover to translocation and microtubule regulation: One engine, many machines. Journal of Muscle Research and Cell Motility, 33(6), 377-383. https://doi.org/10.1007/s10974-012-9289-6

The cycle of ATP turnover is integral to the action of motor proteins. Here we discuss how variation in this cycle leads to variation of function observed amongst members of the kinesin superfamily of microtubule associated motor proteins. Variation... Read More about Coupling of kinesin ATP turnover to translocation and microtubule regulation: One engine, many machines.

Rational diversification of a promoter providing fine-tuned expression and orthogonal regulation for synthetic biology (2012)
Journal Article
Blount, B. A., Weenink, T., Vasylechko, S., & Ellis, T. (2012). Rational diversification of a promoter providing fine-tuned expression and orthogonal regulation for synthetic biology. PLoS ONE, 7(3), Article e33279. https://doi.org/10.1371/journal.pone.0033279

Yeast is an ideal organism for the development and application of synthetic biology, yet there remain relatively few well-characterised biological parts suitable for precise engineering of this chassis. In order to address this current need, we prese... Read More about Rational diversification of a promoter providing fine-tuned expression and orthogonal regulation for synthetic biology.

Novel 3, 6, 7-substituted pyrazolopyrimidines as positive allosteric modulators for the hydroxycarboxylic acid receptor 2 (GPR109A) (2012)
Journal Article
Blad, C. C., van Veldhoven, J. P. D., Klopman, C., Wolfram, D. R., Brussee, J., Lane, J. R., & Ijzerman, A. P. (2012). Novel 3, 6, 7-substituted pyrazolopyrimidines as positive allosteric modulators for the hydroxycarboxylic acid receptor 2 (GPR109A). Journal of Medicinal Chemistry, 55(7), 3563-3567. https://doi.org/10.1021/jm300164q

A number of pyrazolopyrimidines were synthesized and tested for their positive allosteric modulation of the HCA(2) receptor (GPR109A). Compound 24, an efficacious and potent agonist and allosteric enhancer of nicotinic acid's action, was the basis fo... Read More about Novel 3, 6, 7-substituted pyrazolopyrimidines as positive allosteric modulators for the hydroxycarboxylic acid receptor 2 (GPR109A).

A Novel Nonribose Agonist, LUF5834, Engages Residues That Are Distinct from Those of Adenosine-Like Ligands to Activate the Adenosine A2a Receptor (2012)
Journal Article
Lane, J. R., Klein Herenbrink, C., van Westen, G. J. P., Spoorendonk, J. A., Hoffmann, C., & Ijzerman, A. P. (2012). A Novel Nonribose Agonist, LUF5834, Engages Residues That Are Distinct from Those of Adenosine-Like Ligands to Activate the Adenosine A2a Receptor. Molecular Pharmacology, 81(3), 475-487. https://doi.org/10.1124/mol.111.075937

The recent publication of both the antagonist- and agonist-bound structures of the adenosine A(2A) receptor have revealed much about how a ligand may bind to a receptor and cause the conformational changes associated with agonist-mediated activation.... Read More about A Novel Nonribose Agonist, LUF5834, Engages Residues That Are Distinct from Those of Adenosine-Like Ligands to Activate the Adenosine A2a Receptor.

Investigation of the haemodynamic effects of exenatide in healthy male subjects (2012)
Journal Article
Mendis, B., Simpson, E., Macdonald, I., & Mansell, P. (2012). Investigation of the haemodynamic effects of exenatide in healthy male subjects. British Journal of Clinical Pharmacology, 74(3), 437-444. https://doi.org/10.1111/j.1365-2125.2012.04214.x

AIMS In clinical studies of glucagon-like peptide-1 (GLP-1) agonists used in the management of patients with type 2 diabetes, there is often a small accompanying fall in blood pressure. The mechanism underlying this effect is not known, although exen... Read More about Investigation of the haemodynamic effects of exenatide in healthy male subjects.

Construction of synthetic regulatory networks in yeast (2012)
Journal Article
Blount, B. A., Weenink, T., & Ellis, T. (2012). Construction of synthetic regulatory networks in yeast. FEBS Letters, 586(15), 2112-2121. https://doi.org/10.1016/j.febslet.2012.01.053

Yeast species such as Saccharomyces cerevisiae have been exploited by humans for millennia and so it is therefore unsurprising that they are attractive cells to re-engineer for industrial use. Despite many beneficial traits yeast has for synthetic bi... Read More about Construction of synthetic regulatory networks in yeast.

Homobivalent ligands of the atypical antipsychotic clozapine: design, synthesis, and pharmacological evaluation. (2012)
Journal Article
McRobb, F. M., Crosby, I. T., Yuriev, E., Lane, J. R., & Capuano, B. (2012). Homobivalent ligands of the atypical antipsychotic clozapine: design, synthesis, and pharmacological evaluation. Journal of Medicinal Chemistry, 55(4), 1622-1634. https://doi.org/10.1021/jm201420s

To date all typical and atypical antipsychotics target the dopamine D(2) receptor. Clozapine represents the best-characterized atypical antipsychotic, although it displays only moderate (submicromolar) affinity for the dopamine D(2) receptor. Herein,... Read More about Homobivalent ligands of the atypical antipsychotic clozapine: design, synthesis, and pharmacological evaluation..

Tribbles 2 (Trib2) is a novel regulator of toll-like receptor 5 signaling (2012)
Journal Article
Wei, S. C., Rosenberg, I. M., Cao, Z., Huett, A. S., Xavier, R. J., & Podolsky, D. K. (2012). Tribbles 2 (Trib2) is a novel regulator of toll-like receptor 5 signaling. Inflammatory Bowel Diseases, 18(5), 877-888. https://doi.org/10.1002/ibd.22883

Background: Toll-like receptors (TLRs) are expressed by a variety of cells, including intestinal epithelia. However, the full spectrum of regulators modulating innate responses via TLRs has not been delineated. Tribbles (Trib) have been identified as... Read More about Tribbles 2 (Trib2) is a novel regulator of toll-like receptor 5 signaling.

The Role of Humoral Innate Immunity in Hepatitis C Virus Infection (2012)
Journal Article
Tarr, A. W., Urbanowicz, R. A., & Ball, J. K. (2012). The Role of Humoral Innate Immunity in Hepatitis C Virus Infection. Viruses, 4(1), 1-27. https://doi.org/10.3390/v4010001

Infection with Hepatitis C Virus (HCV) causes chronic disease in approximately 80% of cases, resulting in chronic inflammation and cirrhosis. Current treatments are not completely effective, and a vaccine has yet to be developed. Spontaneous resoluti... Read More about The Role of Humoral Innate Immunity in Hepatitis C Virus Infection.

Genetic and biochemical identification of a novel single-stranded DNA-binding complex in Haloferax volcanii (2012)
Journal Article
Stroud, A., Liddell, S., & Allers, T. (2012). Genetic and biochemical identification of a novel single-stranded DNA-binding complex in Haloferax volcanii. Frontiers in Microbiology, 3, Article 224. https://doi.org/10.3389/fmicb.2012.00224

Single-stranded DNA (ssDNA)-binding proteins play an essential role in DNA replication and repair. They use oligonucleotide/oligosaccharide-binding (OB)-folds, a five-stranded β-sheet coiled into a closed barrel, to bind to ssDNA thereby protecting a... Read More about Genetic and biochemical identification of a novel single-stranded DNA-binding complex in Haloferax volcanii.

The role of neutralizing antibodies in hepatitis C virus infection (2012)
Journal Article
Edwards, V. C., Tarr, A. W., Urbanowicz, R. A., & Ball, J. K. (2012). The role of neutralizing antibodies in hepatitis C virus infection. Journal of General Virology, 93(1), 1-19. https://doi.org/10.1099/vir.0.035956-0

Hepatitis C virus (HCV) is a blood-borne virus estimated to infect around 170 million people worldwide and is, therefore, a major disease burden. In some individuals the virus is spontaneously cleared during the acute phase of infection, whilst in ot... Read More about The role of neutralizing antibodies in hepatitis C virus infection.

Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target (2011)
Journal Article
Sanhaji, M., Friel, C. T., Wordeman, L., Louwen, F., & Yuan, J. (2011). Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target. Oncotarget, 2(12), 935-947. https://doi.org/10.18632/oncotarget.416

The inability to faithfully segregate chromosomes in mitosis results in chromosome instability, a hallmark of solid tumors. Disruption of microtubule dynamics contributes highly to mitotic chromosome instability. The kinesin-13 family is critical in... Read More about Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target.

S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures (2011)
Journal Article
Sheridan, G. K., & Dev, K. K. (2012). S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures. Glia, 60(3), 382-392. https://doi.org/10.1002/glia.22272

Sphingosine-1-phosphate receptors (S1PRs) are drug targets for the compound FTY720, which is the first oral therapy developed for treatment of relapsing-remitting multiple sclerosis. S1PRs play a variety of functional roles in the differentiation, pr... Read More about S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures.

Biomimetic tissues on a chip for drug discovery (2011)
Journal Article
Ghaemmaghami, A. M., Hancock, M. J., Harrington, H., Kaji, H., & Khademhosseini, A. (2012). Biomimetic tissues on a chip for drug discovery. Drug Discovery Today, 17(3-4), 173-181. https://doi.org/10.1016/j.drudis.2011.10.029

Developing biologically relevant models of human tissues and organs is an important enabling step for disease modeling and drug discovery. Recent advances in tissue engineering, biomaterials and microfluidics have led to the development of microscale... Read More about Biomimetic tissues on a chip for drug discovery.

Evaluating the effectiveness of a schools-based programme to promote exercise self-efficacy in children and young people with risk factors for obesity: Steps to active kids (STAK) (2011)
Journal Article
Glazebrook, C., Batty, M. J., Mullan, N., MacDonald, I., Nathan, D., Sayal, K., …Hollis, C. (2011). Evaluating the effectiveness of a schools-based programme to promote exercise self-efficacy in children and young people with risk factors for obesity: Steps to active kids (STAK). BMC Public Health, 11, Article 830. https://doi.org/10.1186/1471-2458-11-830

Background Low levels of physical activity in children have been linked to an increased risk of obesity, but many children lack confidence in relation to exercise (exercise self-efficacy). Factors which can impact on confidence include a chronic hea... Read More about Evaluating the effectiveness of a schools-based programme to promote exercise self-efficacy in children and young people with risk factors for obesity: Steps to active kids (STAK).

A fresh insight into transmission of schistosomiasis: A misleading tale of biomphalaria in Lake Victoria (2011)
Journal Article
Standley, C. J., Wade, C. M., & Stothard, J. R. (2011). A fresh insight into transmission of schistosomiasis: A misleading tale of biomphalaria in Lake Victoria. PLoS ONE, 6(10), Article e26563. https://doi.org/10.1371/journal.pone.0026563

Lake Victoria is a known hot-spot for Schistosoma mansoni, which utilises freshwater snails of the genus Biomphalaria as intermediate hosts. Different species of Biomphalaria are associated with varying parasite compatibility, affecting local transmi... Read More about A fresh insight into transmission of schistosomiasis: A misleading tale of biomphalaria in Lake Victoria.