All Outputs (205)

Insulin-like factor 3 as a monitor of endocrine disruption (2013)
Journal Article
Anand-Ivell, R., & Ivell, R. (2014). Insulin-like factor 3 as a monitor of endocrine disruption. Reproduction, 147, Article R87-R95. https://doi.org/10.1530/REP-13-0486

Insulin-like factor 3 (INSL3) is generated and secreted by differentiated interstitial Leydig cells of the testes in both fetal and adult males of all mammalian species so far analyzed. All evidence to date suggests that it is produced constitutively... Read More about Insulin-like factor 3 as a monitor of endocrine disruption.

Circulating insulin-like factor 3 (INSL3) in healthy and infertile women (2013)
Journal Article
Anand-Ivell, R., Tremellen, K., Dai, Y., Heng, K., Yosida, M., Knight, P., & Ivell, R. (2013). Circulating insulin-like factor 3 (INSL3) in healthy and infertile women. Human Reproduction, 28(11), https://doi.org/10.1093/humrep/det3

Study question: How does insulin-like factor 3 (INSL3) concentration in blood vary across the menstrual cycle in women?
Summary answer: INSL3 is secreted by the theca interna cells of growing antral follicles and is phasic in its expression.
What i... Read More about Circulating insulin-like factor 3 (INSL3) in healthy and infertile women.

Regulation of the reproductive cycle and early pregnancy by relaxin family peptides (2013)
Journal Article
Anand-Ivell, R., & Ivell, R. (2014). Regulation of the reproductive cycle and early pregnancy by relaxin family peptides. Molecular and Cellular Endocrinology, 382(1), https://doi.org/10.1016/j.mce.2013.08.010

The relaxin family of peptide hormones are structurally closely related to one another sharing a heterodimeric A–B structure, like that of insulin. They may also be active as unprocessed B–C–A pro-forms. Relaxin has been shown to pay a key role withi... Read More about Regulation of the reproductive cycle and early pregnancy by relaxin family peptides.

The effect of increasing the nutrient and amino acid concentration of milk diets on dairy heifer individual feed intake, growth, development, and lactation performance (2013)
Journal Article
Margerison, J. K., Robarts, A. D., & Reynolds, G. W. (2013). The effect of increasing the nutrient and amino acid concentration of milk diets on dairy heifer individual feed intake, growth, development, and lactation performance. Journal of Dairy Science, 96(10), 6539-6549. https://doi.org/10.3168/jds.2012-6489

Non-classical mechanisms of steroid sensing in the ovary: lessons from the bovine oxytocin model (2013)
Journal Article
Ivell, R., Dai, Y., Mann, N., & Anand-Ivell, R. (2014). Non-classical mechanisms of steroid sensing in the ovary: lessons from the bovine oxytocin model. Molecular and Cellular Endocrinology, 382(1), https://doi.org/10.1016/j.mce.2013.04.016

Steroidogenic tissues such as the ovary, testes or adrenal glands are paradoxical in that they often indicate actions of steroid hormones within a dynamic range of ligand concentration in a high nanomolar or even micromolar level, i.e. at the natural... Read More about Non-classical mechanisms of steroid sensing in the ovary: lessons from the bovine oxytocin model.

INSL3 as a biomarker of Leydig cell functionality (2013)
Journal Article
Ivell, R., Wade, J. D., & Anand-Ivell, R. (2013). INSL3 as a biomarker of Leydig cell functionality. Biology of Reproduction, 88(6), https://doi.org/10.1095/biolreprod.113.108969

Insulin-like factor 3 (INSL3) is a small peptide hormone made and secreted uniquely by mature Leydig cells in the testes of all mammals. Importantly, this expression and secretion appears to be constitutive and therefore reflects the differentiation... Read More about INSL3 as a biomarker of Leydig cell functionality.

Ovarian expression of Insulin-Like peptide 3 (INSL3) and its receptor (RXFP2) during development of bovine antral follicles and corpora lutea and measurement of circulating INSL3 levels during synchronized estrous cycles (2013)
Journal Article
Satchell, L., Glister, C., Bleach, E. C., Glencross, R. G., Bicknell, A. B., Dai, Y., …Knight, P. G. (2013). Ovarian expression of Insulin-Like peptide 3 (INSL3) and its receptor (RXFP2) during development of bovine antral follicles and corpora lutea and measurement of circulating INSL3 levels during synchronized estrous cycles. Endocrinology, 154(5), https://doi.org/10.1210/en.2012-2232

Insulin-like peptide 3 (INSL3), a major product of testicular Leydig cells, is also expressed by the ovary, but its functional role remains poorly understood. Here, we quantified expression of INSL3 and its receptor RXFP2 in theca interna cell (TIC)... Read More about Ovarian expression of Insulin-Like peptide 3 (INSL3) and its receptor (RXFP2) during development of bovine antral follicles and corpora lutea and measurement of circulating INSL3 levels during synchronized estrous cycles.

Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production (2013)
Journal Article
Glister, C., Satchell, L., Bathgate, R. A., Wade, J. D., Dai, Y., Ivell, R., …Knight, P. G. (2013). Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production. Proceedings of the National Academy of Sciences, 110(15), Article E1426-E1435. https://doi.org/10.1073/pnas.1222216110

Bone morphogenetic proteins (BMPs) are firmly implicated as intraovarian regulators of follicle development and steroidogenesis. Here we report a microarray analysis showing that treatment of cultured bovine theca cells (TC) with BMP6 significantly (... Read More about Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production.

Neohormones as biomarkers of reproductive health (2013)
Journal Article
Anand-Ivell, R., Dai, Y., & Ivell, R. (2013). Neohormones as biomarkers of reproductive health. Fertility and Sterility, 99(4), https://doi.org/10.1016/j.fertnstert.2012.12.023

Neohormone systems are defined as evolutionarily new endocrine or paracrine adaptations that supplement basic physiologic functions and define mammalian success. The relaxin family of peptide hormones are typical neohormones. Because they define the... Read More about Neohormones as biomarkers of reproductive health.

Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring (2013)
Journal Article
Ivell, R., Heng, K., Nicholson, H., & Anand-Ivell, R. (2013). Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring. Asian Journal of Andrology, 15(2), https://doi.org/10.1038/aja.2012.138

Maternal exposure to estrogenic xenobiotics or phthalates has been implicated in the distortion of early male reproductive development, referred to in humans as the testicular dysgenesis syndrome. It is not known, however, whether such early gestatio... Read More about Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring.

Basolateral amygdala activity during the retrieval of associative learning under anesthesia (2013)
Journal Article
Fenton, G. E., Spicer, C. H., Halliday, D. M., Mason, R., & Stevenson, C. W. (2013). Basolateral amygdala activity during the retrieval of associative learning under anesthesia. Neuroscience, 233, 146-156. https://doi.org/10.1016/j.neuroscience.2012.12.039

Associative learning can occur under anesthesia and its neural correlates have begun to be elucidated. During discrimination learning under anesthesia in rats, lateral amygdala excitability increases in response to a conditioned stimulus (CS+) previo... Read More about Basolateral amygdala activity during the retrieval of associative learning under anesthesia.

On-farm methane measurements during milking correlate with total methane production by individual dairy cows (2012)
Journal Article
Garnsworthy, P., Craigon, J., Hernandez-Medrano, J., & Saunders, N. (2012). On-farm methane measurements during milking correlate with total methane production by individual dairy cows. Journal of Dairy Science, 95(6), https://doi.org/10.3168/jds.2011-4605

The objective of this study was to investigate whether measurement of methane emissions by individual dairy cows during milking could provide a useful technique for monitoring on-farm methane emissions. To quantify methane emissions from individual c... Read More about On-farm methane measurements during milking correlate with total methane production by individual dairy cows.

Variation among individual dairy cows in methane measurements made on farm during milking (2012)
Journal Article
Garnsworthy, P., Craigon, J., Hernandez-Medrano, J., & Saunders, N. (2012). Variation among individual dairy cows in methane measurements made on farm during milking. Journal of Dairy Science, 95(6), https://doi.org/10.3168/jds.2011-4606

The objective of this study was to quantify on-farm variation between and within cows in methane emissions measured during milking, and to determine which factors are related to this variation. Methane emission rate during milking (MERm) was recorded... Read More about Variation among individual dairy cows in methane measurements made on farm during milking.

Mechanical properties of the bovine claw horn during lactation (2012)
Journal Article
Winkler, B., & Margerison, J. K. (2012). Mechanical properties of the bovine claw horn during lactation. Journal of Dairy Science, 95(4), 1714-1728. https://doi.org/10.3168/jds.2011-4489

Claw horn disorders are one of the main causes of lameness in dairy cows globally. This study aimed to develop material testing techniques to assess changes in the mechanical properties of bovine claw horn (BCH) and to compare these mechanical proper... Read More about Mechanical properties of the bovine claw horn during lactation.

Biosecurity on cattle farms: a study in North-West England (2012)
Journal Article
Brennan, M. L., & Christley, R. M. (2012). Biosecurity on cattle farms: a study in North-West England. PLoS ONE, 7(1), Article e28139. https://doi.org/10.1371/journal.pone.0028139

Background: Few studies have considered in detail the range of biosecurity practices undertaken on cattle farms, particularly within the UK. In this study, 56 cattle farmers in a 100 km2 area of north-west England were questioned regarding their on-f... Read More about Biosecurity on cattle farms: a study in North-West England.

Role of amygdala-prefrontal cortex circuitry in regulating the expression of contextual fear memory (2011)
Journal Article
Stevenson, C. W. (2011). Role of amygdala-prefrontal cortex circuitry in regulating the expression of contextual fear memory. Neurobiology of Learning and Memory, 96(2), 315-323. https://doi.org/10.1016/j.nlm.2011.06.005

The basolateral amygdala (BLA) and medial prefrontal cortex (mPFC) are inter-connected regions involved in fear memory expression. The reciprocal nature of projections between these areas differs along the rostrocaudal extent of BLA. This study inves... Read More about Role of amygdala-prefrontal cortex circuitry in regulating the expression of contextual fear memory.

Early life programming of fear conditioning and extinction in adult male rats (2009)
Journal Article
Stevenson, C. W., Spicer, C. H., Mason, R., & Marsden, C. A. (2009). Early life programming of fear conditioning and extinction in adult male rats. Behavioural Brain Research, 205(2), 505-510. https://doi.org/10.1016/j.bbr.2009.08.005

The early rearing environment programs corticolimbic function and neuroendocrine stress reactivity in adulthood. Although early environmental programming of innate fear has been previously examined, its impact on fear learning and memory later in lif... Read More about Early life programming of fear conditioning and extinction in adult male rats.

Neonatal maternal separation alters reward-related ultrasonic vocalizations in rat dams (2009)
Journal Article
Stevenson, C. W., Goodwin, P. E., Tunstall, B., Spicer, C. H., Marsden, C. A., & Mason, R. (2009). Neonatal maternal separation alters reward-related ultrasonic vocalizations in rat dams. Behavioural Brain Research, 200(1), 232-236. https://doi.org/10.1016/j.bbr.2009.01.035

We examined the effects of brief or long durations of repeated maternal separation (MS) on ultrasonic vocalizations (USVs) in rat dams. 50-kHz USVs putatively identified as maternal in origin were emitted only immediately after pups were returned fol... Read More about Neonatal maternal separation alters reward-related ultrasonic vocalizations in rat dams.

Early life programming of innate fear and fear learning in adult female rats (2008)
Journal Article
Stevenson, C. W., Meredith, J. P., Spicer, C. H., Mason, R., & Marsden, C. A. (2009). Early life programming of innate fear and fear learning in adult female rats. Behavioural Brain Research, 198(1), 51-57. https://doi.org/10.1016/j.bbr.2008.10.021

The early rearing environment can impact on emotional reactivity and learning later in life. In this study the effects of neonatal maternal separation (MS) on innate fear and fear learning were assessed in the adult female rat. Pups were subjected to... Read More about Early life programming of innate fear and fear learning in adult female rats.

Early life programming of hemispheric lateralization and synchronization in the adult medial prefrontal cortex (2008)
Journal Article
Stevenson, C. W., Halliday, D. M., Marsden, C. A., & Mason, R. (2008). Early life programming of hemispheric lateralization and synchronization in the adult medial prefrontal cortex. Neuroscience, 155(3), 852-863. https://doi.org/10.1016/j.neuroscience.2008.06.013

Neonatal maternal separation (MS) in the rat increases the vulnerability to stressors later in life. In contrast, brief handling (H) in early life confers resilience to stressors in adulthood. Early life programming of stress reactivity may involve t... Read More about Early life programming of hemispheric lateralization and synchronization in the adult medial prefrontal cortex.