All Outputs (1369)

Virtual High‐Throughput Screening of Vapor‐Deposited Amphiphilic Polymers for Inhibiting Biofilm Formation (2023)
Journal Article
Feng, Z., Cheng, Y., Khlyustova, A., Wani, A., Franklin, T., Varner, J. D., …Yang, R. (2023). Virtual High‐Throughput Screening of Vapor‐Deposited Amphiphilic Polymers for Inhibiting Biofilm Formation. Advanced Materials Technologies, 8(13), Article 2201533. https://doi.org/10.1002/admt.202201533

Amphiphilic copolymers (AP) represent a class of novel antibiofouling materials whose chemistry and composition can be tuned to optimize their performance. However, the enormous chemistry-composition design space associated with AP makes their perfor... Read More about Virtual High‐Throughput Screening of Vapor‐Deposited Amphiphilic Polymers for Inhibiting Biofilm Formation.

The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study (2023)
Preprint / Working Paper
Swiderski, M., Vinogradova, Y., Knaggs, R., Harman, K., Harwood, R., Prasad, V., …Gran, S. The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study

Introduction
Bullous pemphigoid (BP) is a serious skin disease that results in large painful blisters developing over the body and occurs most commonly in older people (over 70 years). Despite several comorbidities such as stroke and a threefold inc... Read More about The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study.

Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes (2023)
Journal Article
Lay, C. S., Isidro-Llobet, A., Kilpatrick, L. E., Craggs, P. D., & Hill, S. J. (2023). Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes. Nature Communications, 14, Article 2882. https://doi.org/10.1038/s41467-023-38541-2

Association of single nucleotide polymorphisms in the IL-23 receptor with several auto-inflammatory diseases, led to the heterodimeric receptor and its cytokine-ligand IL-23, becoming important drug targets. Successful antibody-based therapies direct... Read More about Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes.

Evolution of the pore structure-transport relationship during catalyst reduction and sintering studied by integrated multi-scale porosimetry and multi-modal imaging (2023)
Journal Article
Mousa, S., Novak, V., Fletcher, R. S., Kelly, G., Garcia, M., Macleod, N., …Rigby, S. P. (2023). Evolution of the pore structure-transport relationship during catalyst reduction and sintering studied by integrated multi-scale porosimetry and multi-modal imaging. Chemical Engineering Science, 277, Article 118880. https://doi.org/10.1016/j.ces.2023.118880

Catalyst pellet fabrication parameters significantly impact final product performance. Tabletted pellets are complex, hierarchical structures that evolve differently over various levels during subsequent processing. Multi-scale porosimetry and multi-... Read More about Evolution of the pore structure-transport relationship during catalyst reduction and sintering studied by integrated multi-scale porosimetry and multi-modal imaging.

Explorative research on health literacy and self-care behaviours among Malaysian type 2 diabetes patients (2023)
Presentation / Conference Contribution
Ahmad Azhari, A. E., Chai, J., & Anderson, C. (2023). Explorative research on health literacy and self-care behaviours among Malaysian type 2 diabetes patients. Research in Social and Administrative Pharmacy, 19(7), 20. https://doi.org/10.1016/j.sapharm.2023.04.059

Engaging trainee pharmacists in schools’ outreach and science communication through the UKHSA ‘Antibiotic Guardian Schools Ambassadors' initiative (2023)
Presentation / Conference Contribution
Thornley, T., Miah, T., Charlesworth, J., Gilham, E., Ayeni, A., Solanki, K., Dunne, R., & Ashiru-Oredope, D. (2023, May). Engaging trainee pharmacists in schools’ outreach and science communication through the UKHSA ‘Antibiotic Guardian Schools Ambassadors' initiative. Presented at Clinical Pharmacy Congress 2023, London, UK

Antimicrobial resistance (AMR) is one of the biggest threats facing humanity today. AMR and stewardship are important topics for early career pharmacists to navigate. In 2022, UK Health Security Agency (UKHSA) and Boots UK collaborated to incorporate... Read More about Engaging trainee pharmacists in schools’ outreach and science communication through the UKHSA ‘Antibiotic Guardian Schools Ambassadors' initiative.

Elastin-like recombinamer-mediated hierarchical mineralization coatings on Zr-16Nb-xTi (x=4,16wt%) alloy surfaces improve biocompatibility (2023)
Journal Article
Xue, R., Deng, X., Xu, X., Tian, Y., Hasan, A., Mata, A., …Liu, L. (2023). Elastin-like recombinamer-mediated hierarchical mineralization coatings on Zr-16Nb-xTi (x=4,16wt%) alloy surfaces improve biocompatibility. Biomaterials Advances, 151, Article 213471. https://doi.org/10.1016/j.bioadv.2023.213471

The biocompatibility of biomedical materials is vital to their applicability and functionality. However, modifying surfaces for enhanced biocompatibility using traditional surface treatment techniques is challenging. We employed a mineralizing elasti... Read More about Elastin-like recombinamer-mediated hierarchical mineralization coatings on Zr-16Nb-xTi (x=4,16wt%) alloy surfaces improve biocompatibility.

Assessing the impact of the ‘Antibiotic Guardian Schools Ambassadors' initiative on trainee pharmacist learning and development (2023)
Presentation / Conference Contribution
Thornley, T., Miah, T., Charlesworth, J., Gilham, E., Ayeni, A., Solanki, K., Dunne, R., & Ashiru-Oredope, D. (2023, May). Assessing the impact of the ‘Antibiotic Guardian Schools Ambassadors' initiative on trainee pharmacist learning and development. Poster presented at Clinical Pharmacy Congress, London, UK

Background and introduction (100)
The World Health Organisation has declared that antimicrobial resistance (AMR) is one of the top 10 global public health threats facing humanity today. It is imperative that AMR and antimicrobial stewardship are rec... Read More about Assessing the impact of the ‘Antibiotic Guardian Schools Ambassadors' initiative on trainee pharmacist learning and development.

Development of biocide coated polymers and their antimicrobial efficacy (2023)
Journal Article
Watson, R., Maxwell, M., Dunn, S., Brooks, A., Jiang, L., Hill, H. J., …de Cogan, F. (2023). Development of biocide coated polymers and their antimicrobial efficacy. Nano Select, 4(7), 442-453. https://doi.org/10.1002/nano.202300005

Microbial contamination of plastic surfaces is a significant source of hospital‐acquired infections. To produce antimicrobial surfaces, chlorhexidine was attached to nitrided acrylonitrile butadiene styrene (ABS). The uniformity of chlorhexidine dist... Read More about Development of biocide coated polymers and their antimicrobial efficacy.

O128 Time trends in opioid prescribing after discharge following colectomy in England: a cross-sectional study (2023)
Presentation / Conference Contribution
Baamer, R., Humes, D., Toh, L., Knaggs, R., & Lobo, D. (2023). O128 Time trends in opioid prescribing after discharge following colectomy in England: a cross-sectional study. British Journal of Surgery, 110(Supplement 3), Article znad101.128. https://doi.org/10.1093/bjs/znad101.128

Introduction Opioid prescribing patterns after discharge following colectomy within a population from England are not well characterised. This study aimed to report changes in opioid prescribing prevalence, formulation choices and opioid analgesics o... Read More about O128 Time trends in opioid prescribing after discharge following colectomy in England: a cross-sectional study.

O087 Predictors of persistent opioid use after discharge following colectomy: a population-based cohort study from England (2023)
Presentation / Conference Contribution
Baamer, R., Humes, D., Toh, L., Knaggs, R., & Lobo, D. (2023). O087 Predictors of persistent opioid use after discharge following colectomy: a population-based cohort study from England. British Journal of Surgery, 110(Supplement 3), Article znad101.087. https://doi.org/10.1093/bjs/znad101.087

Introduction Little is known regarding whether opioid prescriptions following colectomy lead to persistent use. We aimed to determine the prevalence of persistent post-discharge opioid use following colectomy, stratified by preadmission opioid exposu... Read More about O087 Predictors of persistent opioid use after discharge following colectomy: a population-based cohort study from England.

Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts (2023)
Journal Article
Jones, S., Ashworth, J. C., Meakin, M., Collier, P., Probert, C., Ritchie, A. A., Merry, C. L. R., & Grabowska, A. M. (2023). Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts. In Vitro Models, 2(3-4), 99-111. https://doi.org/10.1007/s44164-023-00048-x

Purpose
This 3D in vitro cancer model for propagation of patient-derived cells, using a synthetic self-assembling peptide gel, allows the formation of a fully characterised, tailorable tumour microenvironment. Unlike many existing 3D cancer models,... Read More about Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts.

Conformational analysis and interaction of the Staphylococcus aureus transmembrane peptidase AgrB with its AgrD propeptide substrate (2023)
Journal Article
Bardelang, P., Murray, E. J., Blower, I., Zandomeneghi, S., Goode, A., Hussain, R., …Bonev, B. B. (2023). Conformational analysis and interaction of the Staphylococcus aureus transmembrane peptidase AgrB with its AgrD propeptide substrate. Frontiers in Chemistry, 11, Article 1113885. https://doi.org/10.3389/fchem.2023.1113885

Virulence gene expression in the human pathogen, S. aureus is regulated by the agr (accessory gene regulator) quorum sensing (QS) system which is conserved in diverse Gram-positive bacteria. The agr QS signal molecule is an autoinducing peptide (AIP)... Read More about Conformational analysis and interaction of the Staphylococcus aureus transmembrane peptidase AgrB with its AgrD propeptide substrate.

Connecting inflammatory bowel and neurodegenerative diseases: microRNAs as a shared therapeutic intervention (2023)
Journal Article
Monaghan, T. M., Ugun-Klusek, A., Finelli, M., Gurnani, P., Chakrabarti, L., Kao, D., …Polytarchou, C. (2024). Connecting inflammatory bowel and neurodegenerative diseases: microRNAs as a shared therapeutic intervention. Gut, 73(6), 1034-1036. https://doi.org/10.1136/gutjnl-2022-327301

Conceptualising, evaluating and supporting the development of cosmopolitan values in internationalised higher education: A capabilities approach (2023)
Journal Article
Bridges, S. J. (2023). Conceptualising, evaluating and supporting the development of cosmopolitan values in internationalised higher education: A capabilities approach. Journal of University Teaching & Learning Practice, 20(4), Article 15. https://doi.org/10.53761/1.20.4.15

Internationalised higher education literature draws attention to the tension between the economic returns of recruiting overseas students and the personal, social and cultural possibilities offered. This paper advances the idea that fostering cosmopo... Read More about Conceptualising, evaluating and supporting the development of cosmopolitan values in internationalised higher education: A capabilities approach.

Methylprednisolone alleviates cognitive functions through the regulation of neuroinflammation in Alzheimer’s disease (2023)
Journal Article
Sun, Y., Li, J., A, N., Li, Z., Zhong, W., Chen, L., …Li, X. (2023). Methylprednisolone alleviates cognitive functions through the regulation of neuroinflammation in Alzheimer’s disease. Frontiers in Immunology, 14, Article 1192940. https://doi.org/10.3389/fimmu.2023.1192940

Alzheimer’s disease (AD) is a progressive neurodegenerative disease and linked to abnormal deposition of amyloid-β (Aβ), neurofibrillary tangles (NFTs), synaptic dysfunction, and neuroinflammation. Despite significant progress in unravelling the path... Read More about Methylprednisolone alleviates cognitive functions through the regulation of neuroinflammation in Alzheimer’s disease.

Denosumab as a Pharmacological Countermeasure Against Osteopenia in Long Duration Spaceflight (2023)
Journal Article
Rengel, A. C., Tran, V., & Toh, L. S. (2023). Denosumab as a Pharmacological Countermeasure Against Osteopenia in Long Duration Spaceflight. Aerospace Medicine and Human Performance, 94(5), 389-395. https://doi.org/10.3357/AMHP.6053.2023

INTRODUCTION: Prolonged exposure to microgravity is associated with a significant reduction in bone density, exposing astronauts to renal calculi in flight and osteoporotic fractures on return to Earth. While physical countermeasures and bisphosphona... Read More about Denosumab as a Pharmacological Countermeasure Against Osteopenia in Long Duration Spaceflight.

OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems (2023)
Journal Article
Mendonca, T., Lis-Slimak, K., Matheson, A. B., Smith, M. G., Anane-Adjei, A. B., Ashworth, J. C., …Wright, A. J. (2023). OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems. Communications Biology, 6, Article 463. https://doi.org/10.1038/s42003-023-04780-8

Biomechanical cues from the extracellular matrix (ECM) are essential for directing many cellular processes, from normal development and repair, to disease progression. To better understand cell-matrix interactions, we have developed a new instrument... Read More about OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems.

Apoptotic cell death in disease—Current understanding of the NCCD 2023 (2023)
Journal Article
Vitale, I., Pietrocola, F., Guilbaud, E., Aaronson, S. A., Abrams, J. M., Adam, D., …Galluzzi, L. (2023). Apoptotic cell death in disease—Current understanding of the NCCD 2023. Cell Death and Differentiation, 30(5), 1097-1154. https://doi.org/10.1038/s41418-023-01153-w

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this p... Read More about Apoptotic cell death in disease—Current understanding of the NCCD 2023.

Synthetic extracellular matrices with function-encoding peptides (2023)
Journal Article
Ligorio, C., & Mata, A. (2023). Synthetic extracellular matrices with function-encoding peptides. Nature Reviews Bioengineering, 1, 518–536. https://doi.org/10.1038/s44222-023-00055-3

The communication of cells with their surroundings is mostly encoded in the epitopes of structural and signalling proteins present in the extracellular matrix (ECM). These peptide epitopes can be incorporated in biomaterials to serve as function-enco... Read More about Synthetic extracellular matrices with function-encoding peptides.