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Rapid Detection of Peptide Markers for Authentication Purposes in Raw and Cooked Meat Using Ambient Liquid Extraction Surface Analysis Mass Spectrometry (2014)
Journal Article
Montowska, M., Alexander, M. R., Tucker, G. A., & Barrett, D. A. (2014). Rapid Detection of Peptide Markers for Authentication Purposes in Raw and Cooked Meat Using Ambient Liquid Extraction Surface Analysis Mass Spectrometry. Analytical Chemistry, 86(20), 10257-10265. https://doi.org/10.1021/ac502449w

In this paper, our previously developed ambient LESA-MS methodology is implemented to analyze five types of thermally treated meat species, namely beef, pork, horse, chicken, and turkey meat, in order to select and identify heat-stable and species-sp... Read More about Rapid Detection of Peptide Markers for Authentication Purposes in Raw and Cooked Meat Using Ambient Liquid Extraction Surface Analysis Mass Spectrometry.

Investigation of Localized Delivery of Diclofenac Sodium from Poly(D,L-Lactic Acid-co-Glycolic Acid)/Poly(Ethylene Glycol) Scaffolds Using an In Vitro Osteoblast Inflammation Model (2014)
Journal Article
Sidney, L. E., Heathman, T. R., Britchford, E., Abed, A. A., Rahman, C. V., & Buttery, L. D. (2015). Investigation of Localized Delivery of Diclofenac Sodium from Poly(D,L-Lactic Acid-co-Glycolic Acid)/Poly(Ethylene Glycol) Scaffolds Using an In Vitro Osteoblast Inflammation Model. Tissue Engineering Part A, 21(1-2), 362-373. https://doi.org/10.1089/ten.tea.2014.0100

Nonunion fractures and large bone defects are significant targets for osteochondral tissue engineering strategies. A major hurdle in the use of these therapies is the foreign body response of the host. Herein, we report the development of a bone tiss... Read More about Investigation of Localized Delivery of Diclofenac Sodium from Poly(D,L-Lactic Acid-co-Glycolic Acid)/Poly(Ethylene Glycol) Scaffolds Using an In Vitro Osteoblast Inflammation Model.

Revision workshops in elementary mathematics enhance student performance in routine laboratory calculations (2014)
Journal Article
Sawbridge, J. L., Qureshi, H. K., Boyd, M. J., & Brown, A. M. (2014). Revision workshops in elementary mathematics enhance student performance in routine laboratory calculations. Advances in Physiology Education, 38(3), 239-245. https://doi.org/10.1152/advan.00036.2014

The ability to understand and implement calculations required for molarity and dilution computations that are routinely undertaken in the laboratory are essential skills that should be possessed by all students entering an undergraduate Life Sciences... Read More about Revision workshops in elementary mathematics enhance student performance in routine laboratory calculations.

The development and validation of the Satisfaction Questionnaire for Osteoporosis Prevention in Malaysia (2014)
Journal Article
Lai, P. S. M., Toh, L. S., Wong, K. T., Tan, A. T. B., Low, B. Y., Anderson, C., & Bin-Chia, D. W. (2014). The development and validation of the Satisfaction Questionnaire for Osteoporosis Prevention in Malaysia. Patient Preference and Adherence, 8, 1365- 1381. https://doi.org/10.2147/ppa.s65718

Purpose: To develop and validate the English version of the Satisfaction Questionnaire for Osteoporosis Prevention (SQOP) in Malaysia.

Methods: The SQOP was modified from the Osteoporosis Patient Satisfaction Questionnaire and developed based on l... Read More about The development and validation of the Satisfaction Questionnaire for Osteoporosis Prevention in Malaysia.

Conducting nanofibers and organogels derived from the self-assembly of tetrathiafulvalene-appended dipeptides (2014)
Journal Article

We demonstrate the nonaqueous self-assembly of a low-molecular-mass organic gelator based on an electroactive p-type tetrathiafulvalene (TTF)–dipeptide bioconjugate. We show that a TTF moiety appended with diphenylalanine amide derivative (TTF-FF-NH2... Read More about Conducting nanofibers and organogels derived from the self-assembly of tetrathiafulvalene-appended dipeptides.

Use of humanised rat basophilic leukaemia cell line RSATL8 for the assessment of allergenicity of Schistosoma mansoni proteins (2014)
Journal Article

Background

Parasite-specific IgE is thought to correlate with protection against Schistosoma mansoni infection or re-infection. Only a few molecular targets of the IgE response in S. mansoni infection have been characterised. A better insight into... Read More about Use of humanised rat basophilic leukaemia cell line RSATL8 for the assessment of allergenicity of Schistosoma mansoni proteins.

Stop that nonsense! (2014)
Journal Article
Jopling, C. L. (2014). Stop that nonsense!. eLife, 3, Article e04300. https://doi.org/10.7554/elife.04300

Copyright © 2014, Jopling. Cells can avoid the effects of so-called 'nonsense' mutations by several methods, including a newly discovered mechanism driven by microRNA molecules.

Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation (2014)
Journal Article
Stephens, F. B., Mendis, B., Shannon, C. E., Cooper, S., Ortori, C. A., Barrett, D. A., …Tsintzas, K. (2014). Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation. Clinical Science, 127(5), 315-322. https://doi.org/10.1042/cs20140031

Acylcarnitine accumulation in skeletal muscle and plasma has been observed in numerous models of mitochondrial lipid overload and insulin resistance. Fish oil n3PUFA (omega-3 polyunsaturated fatty acids) are thought to protect against lipid-induced i... Read More about Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation.

An appraisal of the Suzuki cross-coupling reaction for the synthesis of novel fluorescent coumarin derivatives (2014)
Journal Article
Alhaj Zen, A., Aylott, J. W., & Chan, W. C. (2014). An appraisal of the Suzuki cross-coupling reaction for the synthesis of novel fluorescent coumarin derivatives. Tetrahedron Letters, 55(40), https://doi.org/10.1016/j.tetlet.2014.08.058

We report the chemical design and development of 3-aryl-substituted 7-alkoxy-4-methylcoumarins with enhanced fluorogenic properties. The 3-aryl substituents are installed via an optimized Suzuki–Miyaura cross-coupling (SMC) reaction between a 7-alkox... Read More about An appraisal of the Suzuki cross-coupling reaction for the synthesis of novel fluorescent coumarin derivatives.

Potentiation of latent inhibition by haloperidol and clozapine is attenuated in Dopamine D2 receptor (Drd-2) deficient mice: Do antipsychotics influence learning to ignore irrelevant stimuli via both Drd-2 and non-Drd-2 mechanisms? (2014)
Journal Article
O'Callaghan, M., Bay-Richter, C., O’ Tuathaigh, C. M., Heery, D. M., Waddington, J., & Moran, P. M. (2014). Potentiation of latent inhibition by haloperidol and clozapine is attenuated in Dopamine D2 receptor (Drd-2) deficient mice: Do antipsychotics influence learning to ignore irrelevant stimuli via both Drd-2 and non-Drd-2 mechanisms?. Journal of Psychopharmacology, 28(10), https://doi.org/10.1177/0269881114544774

Whether the dopamine Drd-2 receptor is necessary for the behavioural action of antipsychotic drugs is an important question, as Drd-2 antagonism is responsible for their debilitating motor side effects. Using Drd-2 null mice (Drd2 -/-) it has previou... Read More about Potentiation of latent inhibition by haloperidol and clozapine is attenuated in Dopamine D2 receptor (Drd-2) deficient mice: Do antipsychotics influence learning to ignore irrelevant stimuli via both Drd-2 and non-Drd-2 mechanisms?.

Design, synthesis and SAR exploration of tri-substituted 1,2,4-triazoles as inhibitors of the annexin A2–S100A10 protein interaction (2014)
Journal Article
Reddy, T. R., Li, C., Guo, X., Fischer, P. M., & Dekker, L. V. (2014). Design, synthesis and SAR exploration of tri-substituted 1,2,4-triazoles as inhibitors of the annexin A2–S100A10 protein interaction. Bioorganic and Medicinal Chemistry, 22(19), 5378-5391. https://doi.org/10.1016/j.bmc.2014.07.043

Recent target validation studies have shown that inhibition of the protein interaction between annexin A2 and the S100A10 protein may have potential therapeutic benefits in cancer. Virtual screening identified certain 3,4,5-trisubstituted 4H-1,2,4-tr... Read More about Design, synthesis and SAR exploration of tri-substituted 1,2,4-triazoles as inhibitors of the annexin A2–S100A10 protein interaction.

A strategy for characterization of triterpene saponins in Caulophyllum robustum hairy roots by liquid chromatography with electrospray ionization quadrupole time-of-flight mass spectrometry (2014)
Journal Article

Triterpene saponins are important bioactive constituents widely distributed in many plants. Saponins present in Caulophyllum (Berberidaceae) have not been fully characterized. In this study, we studied triterpene saponins from Caulophyllum robustum u... Read More about A strategy for characterization of triterpene saponins in Caulophyllum robustum hairy roots by liquid chromatography with electrospray ionization quadrupole time-of-flight mass spectrometry.

Simultaneous tissue profiling of eicosanoid and endocannabinoid lipid families in a rat model of osteoarthritis (2014)
Journal Article

We describe a novel LC method for the simultaneous and quantitative profiling of 43 oxylipins including eicosanoids, endocannabinoids, and structurally related bioactive lipids with modified acyl groups. The LC-MS/MS method uses switching at a define... Read More about Simultaneous tissue profiling of eicosanoid and endocannabinoid lipid families in a rat model of osteoarthritis.

Identifying patient-level health and social care costs for older adults discharged from acute medical units in England (2014)
Journal Article
Franklin, M., Berdunov, V., Edmans, J., Conroy, S., Gladman, J. R., Tanajewski, L., …Elliott, R. A. (2014). Identifying patient-level health and social care costs for older adults discharged from acute medical units in England. Age and Ageing, 43(5), https://doi.org/10.1093/ageing/afu073

Background: Acute medical units allow for those who need admission to be correctly identified, and for those who could be managed in ambulatory settings to be discharged. However, readmission rates for older people following discharge from acute medi... Read More about Identifying patient-level health and social care costs for older adults discharged from acute medical units in England.

Assessing the safety features of electronic patient medication record systems used in community pharmacies in England (2014)
Journal Article
Ojeleye, O., Avery, A. J., & Boyd, M. J. (2014). Assessing the safety features of electronic patient medication record systems used in community pharmacies in England. British Journal of Clinical Pharmacology, 78(2), 401-409. https://doi.org/10.1111/bcp.12347

Aims: To evaluate the ability of electronic patient medication record (ePMR) systems used in community pharmacies in England to detect and alert users about clinical hazards, errors and other safety problems.
Methods: Between September 2012 and Nove... Read More about Assessing the safety features of electronic patient medication record systems used in community pharmacies in England.

Exploring safety systems for dispensing in community pharmacies: Focusing on how staff relate to organizational components (2014)
Journal Article
Harvey, J., Avery, A. J., Ashcroft, D., Boyd, M., Phipps, D. L., & Barber, N. (2015). Exploring safety systems for dispensing in community pharmacies: Focusing on how staff relate to organizational components. Research in Social and Administrative Pharmacy, 11(2), 216-227. https://doi.org/10.1016/j.sapharm.2014.06.005

Background: Identifying risk is an important facet of a safety practice in an organization. To identify risk, all components within a system of operation should be considered. In clinical safety practice, a team of people, technologies, procedures an... Read More about Exploring safety systems for dispensing in community pharmacies: Focusing on how staff relate to organizational components.

High prevalence of chitotriosidase deficiency in Peruvian Amerindians exposed to chitin-bearing food and enteroparasites (2014)
Journal Article

The human genome encodes a gene for an enzymatically active chitinase (CHIT1) located in a single copy on Chromosome 1, which is highly expressed by activated macrophages and in other cells of the innate immune response. Several dysfunctional mutatio... Read More about High prevalence of chitotriosidase deficiency in Peruvian Amerindians exposed to chitin-bearing food and enteroparasites.

Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds (2014)
Journal Article
Morris, G., Bridge, J., Eltboli, O., Lewis, M., Knox, A., Aylott, J. W., …Rose, F. R. (2014). Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds. AJP - Lung Cellular and Molecular Physiology, 307(1), Article L38-L47. https://doi.org/10.1152/ajplung.00318.2013

Human airway smooth muscle (HASM) contraction plays a central role in regulating airway resistance in both healthy and asthmatic bronchioles. In vitro studies that investigate the intricate mechanisms that regulate this contractile process are predom... Read More about Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds.