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Characterization of the Anticholinesterase and Antioxidant Properties of Phytochemicals from Moringa oleifera as a Potential Treatment for Alzheimer’s Disease (2025)
Journal Article
Aljadaan, A. M., AlSaadi, A. M., Shaikh, I. A., Whitby, A., Ray, A., Kim, D.-H., & Carter, W. G. (2025). Characterization of the Anticholinesterase and Antioxidant Properties of Phytochemicals from Moringa oleifera as a Potential Treatment for Alzheimer’s Disease. Biomedicines, 13(9), Article 2148. https://doi.org/10.3390/biomedicines13092148

Background/Objectives: Alzheimer’s disease (AD) is the most prevalent form of dementia and is characterized by a decline in cognition that may be due, in part, to deficient cholinergic signalling. Cholinesterase inhibitors (ChEIs) are the first-line... Read More about Characterization of the Anticholinesterase and Antioxidant Properties of Phytochemicals from Moringa oleifera as a Potential Treatment for Alzheimer’s Disease.

Changing paradigms of studies in kidney diseases (2025)
Journal Article
Levin, A., Jaure, A., Little, D. J., Schell, J., Lees, J. S., Uwe Eckardt, K.-., Weinfurt, K., Rose, M., Jardine, M. J., Grams, M. E., Schloemer, P., Krishnasamy, R., Sinha, S., Caskey, F. J., Nangaku, M., Wheeler, D. C., Oni, L., Hughes, J. T., Wang, B., Cook, C., …the International Society of Nephrology’s, C.-A. (in press). Changing paradigms of studies in kidney diseases. Kidney International,

Oncologists’ Perspectives on Ketogenic Diets in Pediatric Brain Cancer: Potential, Challenges, and the Path Forward (2025)
Journal Article
AlMutairi, H., Dandapani, M., Siddiqui, K., & McCullough, F. (in press). Oncologists’ Perspectives on Ketogenic Diets in Pediatric Brain Cancer: Potential, Challenges, and the Path Forward. Nutrients, 17(17), Article 2843. https://doi.org/10.3390/nu17172843

Background/objectives: Treating pediatric brain tumors remains challenging due to the limitations of conventional therapies, which often damage healthy cells. Ketogenic diets (KDs)—high in fat and low in carbohydrates—have emerged as potential adjunc... Read More about Oncologists’ Perspectives on Ketogenic Diets in Pediatric Brain Cancer: Potential, Challenges, and the Path Forward.

Improving patient flow: ethnicity and socio-economic status associated with delayed discharge from hospital in patients with COVID-19 infection: An observational epidemiological study (2025)
Journal Article
Crooks, C., West, J., Gazis, T., Morling, J. R., Simmonds, M., Juurlink, I., Briggs, S., Cruickshank, S., Hammond-Pears, S., Shaw, D., Card, T. R., & Fogarty, A. (2025). Improving patient flow: ethnicity and socio-economic status associated with delayed discharge from hospital in patients with COVID-19 infection: An observational epidemiological study. Journal of Research in Nursing, https://doi.org/10.1177/17449871241310384

Background:
Understanding the reasons for delays in leaving hospital once an in-patient is considered ready for discharge is important to inform the development of interventions to improve patient flow through resource-stressed healthcare systems.... Read More about Improving patient flow: ethnicity and socio-economic status associated with delayed discharge from hospital in patients with COVID-19 infection: An observational epidemiological study.

ESPEN Guideline on clinical nutrition in surgery -Update 2025 (2025)
Journal Article
Weimann, A., Bezmarevic, M., Braga, M., Correia, M. T., Funk-Debleds, P., Gianotti, L., Gillis, C., Hübner, M., Inciong, J. F. B., Shukri Jahit, M., Klek, S., Kori, T., Laviano, A., Ljungqvist, O., Lobo, D. N., Loinaz Segurola, C., Montroni, I., Reddy, B. R., Saur, N. M., Schweinlin, A., …Bischoff, S. C. (in press). ESPEN Guideline on clinical nutrition in surgery -Update 2025. Clinical Nutrition,

Early oral feeding is the preferred mode of nutrition for surgical patients. Avoidance of any nutritional therapy bears the risk of underfeeding during the postoperative course after major surgery. Considering that malnutrition and underfeeding are r... Read More about ESPEN Guideline on clinical nutrition in surgery -Update 2025.

Eradication of Helicobacter pylori for prevention of aspirin-associated peptic ulcer bleeding in adults over 65 years: the HEAT RCT (2025)
Journal Article
Hawkey, C., Avery, A. J., Coupland, C. A., Crooks, C. J., Dumbleton, J. S., Hobbs, F. R., Kendrick, D., Moore, M., Morris, C., Rubin, G., Smith, M., & Stevenson, D. (2025). Eradication of Helicobacter pylori for prevention of aspirin-associated peptic ulcer bleeding in adults over 65 years: the HEAT RCT. Health Technology Assessment, 29(42), 1-62. https://doi.org/10.3310/LLKF7871

Background
Peptic ulcers in patients on aspirin are associated with Helicobacter pylori infection. We investigated whether H. pylori eradication would protect against aspirin-associated ulcer bleeding.

Methods
The Helicobacter Eradication Aspiri... Read More about Eradication of Helicobacter pylori for prevention of aspirin-associated peptic ulcer bleeding in adults over 65 years: the HEAT RCT.

Temporary inactivation of the nucleus accumbens shell impairs the acquisition and expression of appetitive inhibitory learning in male Wistar rats (2025)
Journal Article
Waite, L., Bonardi, C., Hock, R., Owusu-Amoah, N., Taylor, C., Stevenson, C., & Cassaday, H. J. (2025). Temporary inactivation of the nucleus accumbens shell impairs the acquisition and expression of appetitive inhibitory learning in male Wistar rats. Neuroscience, 584, 323-333. https://doi.org/10.1016/j.neuroscience.2025.08.035

Temporary inactivation of the nucleus accumbens (NAc) core or shell was used to investigate the roles of these subregions in inhibitory learning. The GABAA receptor agonist muscimol (0.125μg/side in 0.5μl/side) was micro-infused bilaterally in male W... Read More about Temporary inactivation of the nucleus accumbens shell impairs the acquisition and expression of appetitive inhibitory learning in male Wistar rats.

The functional and therapeutic potential of epitranscriptomics in breast cancer (2025)
Journal Article
Thompson, R. L., Lothion-Roy, J., Bellows, E., Woodcock, C. L., Jackson-Oxley, J., Haque, M., Varun, D., Kumari, A. A., Alsaleem, M., de Brot, S., Ntekim, A., Muyangwa-Semanova, M., Rakha, E., Madhusudan, S., Archer, N., Fray, R. G., Irshad, S., Emes, R. D., Jeyapalan, J. N., Rutland, C. S., …Harris, A. E. (2025). The functional and therapeutic potential of epitranscriptomics in breast cancer. Epigenomics, https://doi.org/10.1080/17501911.2025.2542113

Breast cancer (BCa) is one of the most commonly diagnosed malignancies worldwide and is clinically heterogenous. BCa is classified into distinct histopathological and molecular subtypes that inform diagnosis, treatment, and prognosis. Although therap... Read More about The functional and therapeutic potential of epitranscriptomics in breast cancer.

Plasma and Urinary KIM-1 in Chronic Kidney Disease: Prognostic Value, Associations with Albuminuria, and Implications for Kidney Failure and Mortality (2025)
Journal Article
McDonnell, T., Söderberg, M., Taal, M. W., Vuilleumier, N., & Kalra, P. A. (2025). Plasma and Urinary KIM-1 in Chronic Kidney Disease: Prognostic Value, Associations with Albuminuria, and Implications for Kidney Failure and Mortality. American Journal of Nephrology, https://doi.org/10.1159/000547867

Introduction
Kidney injury molecule-1 (KIM-1) expression reflects proximal renal tubular damage, but plasma and urine KIM-1 have not been jointly studied in a CKD cohort.

Methods
Plasma and urine KIM-1 were measured in 2581 adults from the NURTu... Read More about Plasma and Urinary KIM-1 in Chronic Kidney Disease: Prognostic Value, Associations with Albuminuria, and Implications for Kidney Failure and Mortality.

All-cause and non-colorectal cancer 1-year mortality among people having a faecal immunochemical test in primary care for investigation of symptoms of suspected colorectal cancer: an English cohort study (2025)
Journal Article
Malcolm, F. L., Crooks, C. J., West, J., Humes, D. J., & Langan, S. M. (2025). All-cause and non-colorectal cancer 1-year mortality among people having a faecal immunochemical test in primary care for investigation of symptoms of suspected colorectal cancer: an English cohort study. The Lancet Primary Care, Article 100007. https://doi.org/10.1016/j.lanprc.2025.100007

Background
High blood concentrations in stool, as determined by the faecal immunochemical test (FIT), in individuals screened for colorectal cancer are associated with increased mortality. To our knowledge, no studies to date have assessed whether t... Read More about All-cause and non-colorectal cancer 1-year mortality among people having a faecal immunochemical test in primary care for investigation of symptoms of suspected colorectal cancer: an English cohort study.

Temporal Trends in Medical and Surgical Management of Ulcerative Colitis in England: 2003–2020 (2025)
Journal Article
Couch, J., Thomas, K., Card, T. R., & Humes, D. J. (2025). Temporal Trends in Medical and Surgical Management of Ulcerative Colitis in England: 2003–2020. Alimentary Pharmacology and Therapeutics, https://doi.org/10.1111/apt.70319

Background
The medical management of ulcerative colitis (UC) is evolving. However, colectomy may be required in severe or refractory cases.

Aim
To provide contemporary evidence on medication usage and surgery for UC.

Methods
An incident coho... Read More about Temporal Trends in Medical and Surgical Management of Ulcerative Colitis in England: 2003–2020.

Assessment of Vault Particles in Cancer Cell Line‐Derived Extracellular Vesicle Preparations (2025)
Journal Article
Liu, X., Nizamudeen, Z. A., Hill, C. J., Parmenter, C., Arkill, K. P., Lambert, D. W., & Hunt, S. (2025). Assessment of Vault Particles in Cancer Cell Line‐Derived Extracellular Vesicle Preparations. Journal of Extracellular Vesicles, 14(8), Article e70142. https://doi.org/10.1002/jev2.70142

Extracellular vesicles (EVs) may contain a variety of molecular cargo, including proteins and nucleic acids. Vault particle components have been repeatedly reported in the literature as EV cargo. Here, we demonstrated that vault RNA (vtRNA) and major... Read More about Assessment of Vault Particles in Cancer Cell Line‐Derived Extracellular Vesicle Preparations.

Inflammation-related microRNA alterations in epilepsy: a systematic review of human and animal studies (2025)
Journal Article
Yousefi, M. J., Rezvanimehr, A., Saleki, K., Mehrani, A., Barootchi, E., Ramezankhah, M., Mazloomi, A., Nateri, A. S., Barootchi, S., & Rezaei, N. (2025). Inflammation-related microRNA alterations in epilepsy: a systematic review of human and animal studies. Reviews in the Neurosciences, https://doi.org/10.1515/revneuro-2025-0041

Epilepsy is a neurological condition that affects around 50 million people globally. While the underlying mechanism of epilepsy is not fully understood, emerging evidence demonstrates that inflammation is a key player in the pathogenesis of epilepsy.... Read More about Inflammation-related microRNA alterations in epilepsy: a systematic review of human and animal studies.

Investigation of ribociclib, abemaciclib and palbociclib resistance in ER+ breast cancer cells reveal potential therapeutic opportunities (2025)
Journal Article
Algethami, M., Shoqafi, A., Lashen, A., Alqahtani, S., Spicer, J., ALtayyar, A., Tosun, Ç., Jeyapalan, J. N., Mongan, N. P., James, V., Rakha, E. A., & Madhusudan, S. (2025). Investigation of ribociclib, abemaciclib and palbociclib resistance in ER+ breast cancer cells reveal potential therapeutic opportunities. Scientific Reports, 15(1), Article 28579. https://doi.org/10.1038/s41598-025-11052-4

The cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) ribociclib, abemaciclib, and palbociclib have transformed outcomes in patients with ER+ /HER2 − advanced breast cancer (BC). However, most patients eventually progress, and therapeutic options beyon... Read More about Investigation of ribociclib, abemaciclib and palbociclib resistance in ER+ breast cancer cells reveal potential therapeutic opportunities.

Enhancing Rare Disease Awareness and Education Among Medical Professionals and Students in Türkiye (2025)
Journal Article
Karagöz, Ö., Tırtır, B., Güneş, D., Özgen, Ö., Özçetin, M., Gökçay, G., Gökçay, G. F., Nateri, A. S., & Atalar, F. (2025). Enhancing Rare Disease Awareness and Education Among Medical Professionals and Students in Türkiye. Journal of Evaluation in Clinical Practice, 31(5), Article e70242. https://doi.org/10.1111/jep.70242

Purpose: Rare diseases (RDs), which are often chronic, degenerative, and life-threatening conditions, pose significant challenges due to their complexity and limited awareness among healthcare professionals. This study assessed the knowledge, awarene... Read More about Enhancing Rare Disease Awareness and Education Among Medical Professionals and Students in Türkiye.

Cytology and Core Biopsy for Cystic Lesions of the Pancreas: A Comparison of Three Cytological Grading Systems (2025)
Journal Article
Bancu, A., Hanks, M., Ackroyd, L., Suresh, V., Lobo, D. N., & Zaitoun, A. M. (2025). Cytology and Core Biopsy for Cystic Lesions of the Pancreas: A Comparison of Three Cytological Grading Systems. Journal of Cytology, 42(3), 151-162. https://doi.org/10.4103/joc.joc_6_25

Introduction: Cytological appearances may be insufficient to establish the diagnosis of pancreatic cystic lesions, especially for premalignant neoplasms. This study aimed to evaluate three commonly used cytological grading systems [C1–C5, Papanicolao... Read More about Cytology and Core Biopsy for Cystic Lesions of the Pancreas: A Comparison of Three Cytological Grading Systems.

How to drug a leukemic stem cell: deciphering heterogeneity for better specificity (2025)
Journal Article
Worker, A., Jinks, N., Woodmancy, P., Seedhouse, C., & Kellaway, S. G. (2025). How to drug a leukemic stem cell: deciphering heterogeneity for better specificity. 00 Journal not listed, Article 100146. https://doi.org/10.1016/j.bneo.2025.100146

Blood cancers such as acute myeloid leukemia (AML) are increasingly common due to an aging population but remain challenging to treat. Relapse is the most important singular cause of treatment failure in AML, and up to half of patients relapse after... Read More about How to drug a leukemic stem cell: deciphering heterogeneity for better specificity.

Immunomodulators and advanced therapies for induction of remission in Crohn's disease: a systematic review and network meta-analysis (2025)
Journal Article
Radford, S., & Moran, G. (in press). Immunomodulators and advanced therapies for induction of remission in Crohn's disease: a systematic review and network meta-analysis. Inflammatory Bowel Diseases, https://doi.org/10.1093/ibd/izaf191

Background: Previous reviews for CD treatment have rarely considered advanced and immunomodulator medical therapies together. Our aim was to compare all therapies for efficacy and safety in induction of remission.
Methods: We searched databases up t... Read More about Immunomodulators and advanced therapies for induction of remission in Crohn's disease: a systematic review and network meta-analysis.