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Experimental evidence for early nutritional programming of later health in animals (2006)
Journal Article
Symonds, M. E., & Gardner, D. S. (2006). Experimental evidence for early nutritional programming of later health in animals. Current Opinion in Clinical Nutrition and Metabolic Care, 9(3), 278-283. https://doi.org/10.1097/01.mco.0000222112.46042.19

PURPOSE OF REVIEW: The developmental origins of adult disease represent a burgeoning area of research for which it has been suggested that up to 50% of the current incidence of later adult disease may be explained or even alleviated. Therefore, it is... Read More about Experimental evidence for early nutritional programming of later health in animals.

Antibody and IFN-γ responses induced by a recombinant canarypox vaccine and challenge infection with equine influenza virus (2006)
Journal Article
Paillot, R., Kydd, J., Sindle, T., Hannant, D., Toulemonde, C. E., Audonnet, J., Minke, J., & Daly, J. (2006). Antibody and IFN-γ responses induced by a recombinant canarypox vaccine and challenge infection with equine influenza virus. Veterinary Immunology and Immunopathology, 112(3-4), 225-233. https://doi.org/10.1016/j.vetimm.2006.02.007

In horses, equine influenza virus (EIV) is a leading cause of respiratory disease. Conventional inactivated vaccines induce a short-lived immune response. By comparison, natural infection confers a long-term immunity to re-infection. An aim of new eq... Read More about Antibody and IFN-γ responses induced by a recombinant canarypox vaccine and challenge infection with equine influenza virus.

Development of baroreflex function and hind limb vascular reactivity in the horse fetus (2006)
Journal Article
O'Connor, S. J., Ousey, J. C., Gardner, D. S., Fowden, A. L., & Giussani, D. A. (2006). Development of baroreflex function and hind limb vascular reactivity in the horse fetus. Journal of Physiology, 572(1), 155-164. https://doi.org/10.1113/jphysiol.2006.105635

This study investigated in vivo, the mechanisms underlying the development of cardiovascular function in the horse fetus, with particular relevance to baroreflex function and hind limb vascular arterial reactivity to constrictor agonists. Under gener... Read More about Development of baroreflex function and hind limb vascular reactivity in the horse fetus.

Investigation of Equine Influenza Cases Exhibiting Neurological Disease: Coincidence or Association? (2006)
Journal Article
Daly, J., Whitwell, K., Miller, J., Dowd, G., Cardwell, J., & Smith, K. (2006). Investigation of Equine Influenza Cases Exhibiting Neurological Disease: Coincidence or Association?. Journal of Comparative Pathology, 134(2-3), 231-235. https://doi.org/10.1016/j.jcpa.2005.09.001

Equine influenza is usually a transient and self-limiting disease. However, during an outbreak of equine influenza in the UK in 2003 there were reports of unusually severe clinical signs among unvaccinated animals. Two influenza-infected horses devel... Read More about Investigation of Equine Influenza Cases Exhibiting Neurological Disease: Coincidence or Association?.

Vaccination against equine influenza: Quid novi? (2006)
Journal Article
Paillot, R., Hannant, D., Kydd, J., & Daly, J. (2006). Vaccination against equine influenza: Quid novi?. Vaccine, 24(9), 4047-4061. https://doi.org/10.1016/j.vaccine.2006.02.030

Equine influenza virus is a leading cause of respiratory disease in the horse. Equine influenza vaccines containing inactivated virus were first developed in the 1960s. Despite their intensive use, equine influenza outbreaks still continue to occur a... Read More about Vaccination against equine influenza: Quid novi?.

Description of the outbreak of equine influenza (H3N8) in the United Kingdom in 2003, during which recently vaccinated horses in Newmarket developed respiratory disease (2006)
Journal Article
Newton, J., Daly, J., Spencer, L., & Mumford, J. (2006). Description of the outbreak of equine influenza (H3N8) in the United Kingdom in 2003, during which recently vaccinated horses in Newmarket developed respiratory disease. Veterinary Record, 158(6), 185-192. https://doi.org/10.1136/vr.158.6.185

Between March and May 2003, equine influenza virus infection was confirmed as the cause of clinical respiratory disease among both vaccinated and unvaccinated horses of different breeds and types in at least 12 locations in the UK. In the largest out... Read More about Description of the outbreak of equine influenza (H3N8) in the United Kingdom in 2003, during which recently vaccinated horses in Newmarket developed respiratory disease.

Mutations of the TGF-β type II receptor BMPR2 in pulmonary arterial hypertension (2006)
Journal Article
Machado, R. D., Aldred, M. A., James, V., Harrison, R. E., Patel, B., Schwalbe, E. C., Gruenig, E., Janssen, B., Koehler, R., Seeger, W., Eickelberg, O., Olschewski, H., Gregory Elliott, C., Glissmeyer, E., Carlquist, J., Kim, M., Torbicki, A., Fijalkowska, A., Szewczyk, G., Parma, J., …Trembath, R. C. (2006). Mutations of the TGF-β type II receptor BMPR2 in pulmonary arterial hypertension. Human Mutation, 27(2), 121-132. https://doi.org/10.1002/humu.20285

Pulmonary arterial hypertension (PAH) is clinically characterized by a sustained elevation in mean pulmonary artery pressure leading to significant morbidity and mortality. The disorder is typically sporadic, and in such cases the term idiopathic PAH... Read More about Mutations of the TGF-β type II receptor BMPR2 in pulmonary arterial hypertension.

BMPR2 gene rearrangements account for a significant proportion of mutations in familial and idiopathic pulmonary arterial hypertension (2006)
Journal Article
Aldred, M. A., Vijayakrishnan, J., James, V., Soubrier, F., Gomez-Sanchez, M. A., Martensson, G., Galie, N., Manes, A., Corris, P., Simonneau, G., Humbert, M., Morrell, N. W., & Trembath, R. C. (2006). BMPR2 gene rearrangements account for a significant proportion of mutations in familial and idiopathic pulmonary arterial hypertension. Human Mutation, 27(2), 212-213. https://doi.org/10.1002/humu.9398

Comments on Point:Counterpoint “Positive effects of intermittent hypoxia (live high:train low) on exercise performance are/are not mediated primarily by augmented red cell volume” (2005)
Journal Article
Noakes, T. D., Di Prampero, P. E., Capelli, C., Zaobornyj, T., Valdez, L. B., Boveris, A., Ashenden, M., Secomb, T. W., Dufour, S., Ponsot, E., Zoll, J., Richard, R., Messonnier, L., Gonzalez, N. C., Henderson, K. K., Favret, F., Richalet, J. P., Eltzschig, H. K., Kempf, V. A., Nikinmaa, M., …Ekblom, B. (2005). Comments on Point:Counterpoint “Positive effects of intermittent hypoxia (live high:train low) on exercise performance are/are not mediated primarily by augmented red cell volume”. Journal of Applied Physiology, 99(6), 2453-2462. https://doi.org/10.1152/japplphysiol.01157.2005

Inhaled zanamivir versus rimantadine for the control of influenza in a highly vaccinated long-term care population (2005)
Journal Article
Gravenstein, S., Drinka, P., Osterweil, D., Schilling, M., Krause, P., Elliott, M., Shult, P., Ambrozaitis, A., Kandel, R., Binder, E., Hammond, J., McElhaney, J., Flack, N., Daly, J., & Keene, O. (2005). Inhaled zanamivir versus rimantadine for the control of influenza in a highly vaccinated long-term care population. Journal of the American Medical Directors Association, 6(6), 359-366. https://doi.org/10.1016/j.jamda.2005.08.006

Background

Despite vaccination, influenza commonly causes morbidity and mortality in institutional settings. Influenza control with rimantadine and amantadine is limited by emergence and transmission of drug-resistant influenza A variants, ineffec... Read More about Inhaled zanamivir versus rimantadine for the control of influenza in a highly vaccinated long-term care population.

Characterisation of CTL and IFN-γ synthesis in ponies following vaccination with a NYVAC-based construct coding for EHV-1 immediate early gene, followed by challenge infection (2005)
Journal Article
Paillot, R., Ellis, S., Daly, J., Audonnet, J., Minke, J., Davis-Poynter, N., Hannant, D., & Kydd, J. (2006). Characterisation of CTL and IFN-γ synthesis in ponies following vaccination with a NYVAC-based construct coding for EHV-1 immediate early gene, followed by challenge infection. Vaccine, 24(10), 1490-1500. https://doi.org/10.1016/j.vaccine.2005.10.019

Equine herpesvirus-1 (EHV-1) is a ubiquitous pathogen of horses, which continues to cause respiratory and neurological disease and abortion, despite the widespread use of vaccines. Cell mediated immunity (CMI) is thought to play a major role in prote... Read More about Characterisation of CTL and IFN-γ synthesis in ponies following vaccination with a NYVAC-based construct coding for EHV-1 immediate early gene, followed by challenge infection.

Maternal nutritional programming of fetal adipose tissue development: Long-term consequences for later obesity (2005)
Journal Article
Budge, H., Gnanalingham, M. G., Gardner, D. S., Mostyn, A., Stephenson, T., & Symonds, M. E. (2005). Maternal nutritional programming of fetal adipose tissue development: Long-term consequences for later obesity. Birth Defects Research Part C: Embryo Today: Reviews, 75(3), 193-199. https://doi.org/10.1002/bdrc.20044

As obesity reaches epidemic levels in the United States there is an urgent need to understand the developmental pathways leading to this condition. Obesity increases the risk of hypertension and diabetes, symptoms of which are being seen with increas... Read More about Maternal nutritional programming of fetal adipose tissue development: Long-term consequences for later obesity.

The use of a systemic prime/mucosal boost strategy with an equine influenza ISCOM vaccine to induce protective immunity in horses (2005)
Journal Article
Crouch, C., Daly, J., Henley, W., Hannant, D., Wilkins, J., & Francis, M. (2005). The use of a systemic prime/mucosal boost strategy with an equine influenza ISCOM vaccine to induce protective immunity in horses. Veterinary Immunology and Immunopathology, 108(3-4), 345-355. https://doi.org/10.1016/j.vetimm.2005.06.009

In horses, natural infection confers long lasting protective immunity characterised by mucosal IgA and humoral IgGa and IgGb responses. In order to investigate the potential of locally administered vaccine to induce a protective IgA response, respons... Read More about The use of a systemic prime/mucosal boost strategy with an equine influenza ISCOM vaccine to induce protective immunity in horses.

Equine interferon gamma synthesis in lymphocytes after in vivo infection and in vitro stimulation with EHV-1 (2005)
Journal Article
Paillot, R., Daly, J., Juillard, V., Minke, J., Hannant, D., & Kydd, J. (2005). Equine interferon gamma synthesis in lymphocytes after in vivo infection and in vitro stimulation with EHV-1. Vaccine, 23(36), 4541-4551. https://doi.org/10.1016/j.vaccine.2005.03.048

Equine cytotoxic T lymphocyte (CTL) responses to equine herpesvirus-1 (EHV-1) are well characterised but little is known about the cytokine response after infection or vaccination. EHV-1 is common in horses and infects lymphocytes in vivo. This virus... Read More about Equine interferon gamma synthesis in lymphocytes after in vivo infection and in vitro stimulation with EHV-1.

Efficacy of a recombinant equine influenza vaccine against challenge with an American lineage H3N8 influenza virus responsible for the 2003 outbreak in the United Kingdom (2005)
Journal Article
Edlund Toulemonde, C., Daly, J., Sindle, T., Guigal, P., Audonnet, J., & Minke, J. (2005). Efficacy of a recombinant equine influenza vaccine against challenge with an American lineage H3N8 influenza virus responsible for the 2003 outbreak in the United Kingdom. Veterinary Record, 156(12), 367-371. https://doi.org/10.1136/vr.156.12.367

Fifteen influenza-naive Welsh mountain ponies were randomly assigned to three groups of five. A single dose of a recombinant ALVAC vaccine was administered intramuscularly to five of the ponies, two doses, administered five weeks apart, were administ... Read More about Efficacy of a recombinant equine influenza vaccine against challenge with an American lineage H3N8 influenza virus responsible for the 2003 outbreak in the United Kingdom.

Real-time reverse transcriptase PCR for the endogenous koala retrovirus reveals an association between plasma viral load and neoplastic disease in koalas (2005)
Journal Article
Tarlinton, R., Meers, J., Hanger, J., & Young, P. (2005). Real-time reverse transcriptase PCR for the endogenous koala retrovirus reveals an association between plasma viral load and neoplastic disease in koalas. Journal of General Virology, 86(3), 783-787. https://doi.org/10.1099/vir.0.80547-0

Koala retrovirus (KoRV) is a newly described endogenous retrovirus and is unusual in that inserts comprise a full-length replication competent genome. As koalas are known to suffer from an extremely high incidence of leukaemia/lymphoma, the associati... Read More about Real-time reverse transcriptase PCR for the endogenous koala retrovirus reveals an association between plasma viral load and neoplastic disease in koalas.