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The association between drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based case-control study (2024)
Journal Article
Swiderski, M., Vinogradova, Y., Knaggs, R., Harman, K., Harwood, R., Prasad, V., Persson, M., Figueredo, G., Layfield, C., & Gran, S. (2024). The association between drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based case-control study. British Journal of Dermatology, https://doi.org/10.1093/bjd/ljae416

Background
Bullous pemphigoid (BP) is an autoimmune skin disease that affects mainly older people. Numerous drugs have been previously associated with BP based on case series and small hospital-based studies. More reliable and precise estimates of a... Read More about The association between drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based case-control study.

The association between drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a case-control study (2024)
Journal Article
Swiderski, M., Vinogradova, Y., Knaggs, R. D., Harman, K., Harwood, R. H., Prasad, V., Persson, M. S. M., Figueredo, G., Layfield, C., & Gran, S. (2024). The association between drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a case-control study. British Journal of Dermatology, Article ljae416. https://doi.org/10.1093/bjd/ljae416

Background
Bullous pemphigoid (BP) is an autoimmune skin disease that affects mainly older people. Numerous drugs have been previously associated with BP based on case series and small hospital-based studies. More reliable and precise estimates of a... Read More about The association between drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a case-control study.

A protocol to assess risk of fractures associated with use of menopausal hormone therapy: nested case-control study using CPRD (2024)
Preprint / Working Paper
Vinogradova, Y., Iyen, B., Masud, T., Taylor, L., & Kai, J. A protocol to assess risk of fractures associated with use of menopausal hormone therapy: nested case-control study using CPRD

Menopausal hormone therapy (MHT) is prescribed to women with severe symptoms of menopause. Various studies have demonstrated increased bone density and decreased fracture risk in women using MHT. The randomised controlled trials were, however, run ov... Read More about A protocol to assess risk of fractures associated with use of menopausal hormone therapy: nested case-control study using CPRD.

Sodium-glucose cotransporter-2 inhibitors (SGLT2) in frail or older people with type 2 diabetes and heart failure: a systematic review and meta-analysis (2024)
Journal Article
Aldafas, R., Crabtree, T., Alkharaiji, M., Vinogradova, Y., & Idris, I. (2024). Sodium-glucose cotransporter-2 inhibitors (SGLT2) in frail or older people with type 2 diabetes and heart failure: a systematic review and meta-analysis. Age and Ageing, 53(1), Article afad254. https://doi.org/10.1093/ageing/afad254

Objective: Sodium-glucose cotransporter-2 inhibitors (SGLT2Is) reduce cardio-metabolic and renal outcomes in patients with type 2 diabetes (T2D) but their efficacy and safety in older or frail individuals remains unclear. Methods: We searched PubMed,... Read More about Sodium-glucose cotransporter-2 inhibitors (SGLT2) in frail or older people with type 2 diabetes and heart failure: a systematic review and meta-analysis.

Rates of medical or surgical treatment for women with heavy menstrual bleeding: the ECLIPSE trial 10-year observational follow-up study (2023)
Journal Article
Kai, J., Dutton, B., Vinogradova, Y., Hilken, N., Gupta, J., & Daniels, J. (2023). Rates of medical or surgical treatment for women with heavy menstrual bleeding: the ECLIPSE trial 10-year observational follow-up study. Health Technology Assessment, 27(17), https://doi.org/10.3310/jhsw0174

Background: Heavy menstrual bleeding is a common problem that can significantly affect women’s lives until menopause. There is a lack of evidence on longer-term outcomes after seeking health care and treatment for heavy menstrual bleeding. Objectives... Read More about Rates of medical or surgical treatment for women with heavy menstrual bleeding: the ECLIPSE trial 10-year observational follow-up study.

The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study (2023)
Preprint / Working Paper
Swiderski, M., Vinogradova, Y., Knaggs, R., Harman, K., Harwood, R., Prasad, V., …Gran, S. The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study

Introduction
Bullous pemphigoid (BP) is a serious skin disease that results in large painful blisters developing over the body and occurs most commonly in older people (over 70 years). Despite several comorbidities such as stroke and a threefold inc... Read More about The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study.

Efficacy and safety of intensive versus conventional glucose targets in people with type 2 diabetes: a systematic review and meta-analysis (2023)
Journal Article
Aldafas, R., Crabtree, T., Vinogradova, Y., Gordon, J. P., & Idris, I. (2023). Efficacy and safety of intensive versus conventional glucose targets in people with type 2 diabetes: a systematic review and meta-analysis. Expert Review of Endocrinology and Metabolism, 18(1), 95-110. https://doi.org/10.1080/17446651.2023.2166489

Objective: The aim of study is to re-evaluate the risk-benefits of intensive glycemic control in the context of multi-factorial intervention in adults with T2D.

Methods: We searched Ovid MEDLINE, Embase, Cochrane, and CINHAL for randomized contro... Read More about Efficacy and safety of intensive versus conventional glucose targets in people with type 2 diabetes: a systematic review and meta-analysis.

Medical treatment for heavy menstrual bleeding in primary care: 10-year data from the ECLIPSE trial (2022)
Journal Article
Kai, J., Dutton, B., Vinogradova, Y., Hilken, N., Gupta, J., & Daniels, J. (2022). Medical treatment for heavy menstrual bleeding in primary care: 10-year data from the ECLIPSE trial. British Journal of General Practice, 72(725), e857-e864. https://doi.org/10.3399/bjgp.2022.0260

Background Heavy menstrual bleeding (HMB) is a common problem that can significantly affect women's lives. There is a lack of evidence on long-term outcomes after seeking treatment. Aim To assess continuation rates of medical treatments and rates of... Read More about Medical treatment for heavy menstrual bleeding in primary care: 10-year data from the ECLIPSE trial.

Intensive glycemic control and macrovascular, microvascular, hypoglycemia complications and mortality in older (age ≥60years) or frail adults with type 2 diabetes: a systematic review and meta-analysis from randomized controlled trial and observation studies (2022)
Journal Article
Crabtree, T., Ogendo, J. J., Vinogradova, Y., Gordon, J., & Idris, I. (2022). Intensive glycemic control and macrovascular, microvascular, hypoglycemia complications and mortality in older (age ≥60years) or frail adults with type 2 diabetes: a systematic review and meta-analysis from randomized controlled trial and observation studies. Expert Review of Endocrinology and Metabolism, https://doi.org/10.1080/17446651.2022.2079495

Introduction: Guidelines for type 2 diabetes (T2D) recommend individualized HbA1c targets to take into account patient age or frailty. We synthesized evidence from randomized controlled trials and observational studies for intensive glycemic control... Read More about Intensive glycemic control and macrovascular, microvascular, hypoglycemia complications and mortality in older (age ≥60years) or frail adults with type 2 diabetes: a systematic review and meta-analysis from randomized controlled trial and observation studies.

Ethnic disparities in mortality among overweight or obese adults with newly diagnosed type 2 diabetes: a population-based cohort study (2022)
Journal Article
Iyen, B., Vinogradova, Y., Akyea, R. K., Weng, S., Qureshi, N., & Kai, J. (2022). Ethnic disparities in mortality among overweight or obese adults with newly diagnosed type 2 diabetes: a population-based cohort study. Journal of Endocrinological Investigation, 45(5), 1011-1020. https://doi.org/10.1007/s40618-021-01736-9

Purpose: Ethnic variation in risk of type 2 diabetes is well established, but its impact on mortality is less well understood. This study investigated the risk of all-cause and cardiovascular mortality associated with newly diagnosed type 2 diabetes... Read More about Ethnic disparities in mortality among overweight or obese adults with newly diagnosed type 2 diabetes: a population-based cohort study.

Long-term oral prednisolone exposure in primary care for bullous pemphigoid: population-based study (2021)
Journal Article
Persson, M. S., Harman, K. E., Thomas, K. S., Chalmers, J. R., Vinogradova, Y., Langan, S. M., …Gran, S. (2021). Long-term oral prednisolone exposure in primary care for bullous pemphigoid: population-based study. British Journal of General Practice, 71(713), e904-e911. https://doi.org/10.3399/BJGP.2020.0870

Background: Oral prednisolone is the mainstay treatment for bullous pemphigoid, an autoimmune blistering skin disorder affecting older people. Treatment with moderate-to-high doses is often initiated in secondary care, but then continued in primary c... Read More about Long-term oral prednisolone exposure in primary care for bullous pemphigoid: population-based study.

Use of menopausal hormone therapy and risk of dementia: Nested case-control studies using QResearch and CPRD databases (2021)
Journal Article
Vinogradova, Y., Dening, T., Hippisley-Cox, J., Taylor, L., Moore, M., & Coupland, C. (2021). Use of menopausal hormone therapy and risk of dementia: Nested case-control studies using QResearch and CPRD databases. British Medical Journal, 374, Article n2182. https://doi.org/10.1136/bmj.n2182

Objective To assess the risks of developing dementia associated with different types and durations of menopausal hormone therapy. Design Two nested case-control studies. Setting UK general practices contributing to QResearch or the Clinical Practice... Read More about Use of menopausal hormone therapy and risk of dementia: Nested case-control studies using QResearch and CPRD databases.

Long-term body mass index changes in overweight and obese adults and the risk of heart failure, cardiovascular disease and mortality: a cohort study of over 260,000 adults in the UK (2021)
Journal Article
Iyen, B., Weng, S., Vinogradova, Y., Akyea, R. K., Qureshi, N., & Kai, J. (2021). Long-term body mass index changes in overweight and obese adults and the risk of heart failure, cardiovascular disease and mortality: a cohort study of over 260,000 adults in the UK. BMC Public Health, 21, Article 576. https://doi.org/10.1186/s12889-021-10606-1

Background: Although obesity is a well-recognised risk factor for cardiovascular disease (CVD), the impact of long-term body mass index (BMI) changes in overweight or obese adults, on the risk of heart failure, CVD and mortality has not been quantifi... Read More about Long-term body mass index changes in overweight and obese adults and the risk of heart failure, cardiovascular disease and mortality: a cohort study of over 260,000 adults in the UK.

Hormone replacement therapy and dementia risk: nested case-control studies using CPRD and QResearch (2021)
Journal Article
Vinogradova, Y., Dening, T., Hippisley-Cox, J., Taylor, L., Moore, M., & Coupland, C. (2021). Hormone replacement therapy and dementia risk: nested case-control studies using CPRD and QResearch. East Midlands Research into Ageing Network (EMRAN) Discussion Paper Series, 38, 1-16

Introduction: Research from clinical trials of hormone replacement therapy (HRT) has produced conflicting findings about possible risks of dementia after receiving these treatments, and further research on HRT and dementia risk has been identified as... Read More about Hormone replacement therapy and dementia risk: nested case-control studies using CPRD and QResearch.

Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases (2020)
Journal Article
Vinogradova, Y., Coupland, C., & Hippisley-Cox, J. (2020). Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases. BMJ, 371, Article m3873. https://doi.org/10.1136/bmj.m3873

Objective: To assess breast cancer risks associated with different types and durations of hormone replacement therapy

Design: Two nested case-control studies

Setting: UK general practices contributing to QResearch or Clinical Practice Research... Read More about Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases.

Protocol to assess risk of breast cancer associated with use of hormone replacement therapy in real world settings: two nested case-control studies in primary care. (2019)
Other
Vinogradova, Y., Coupland, C., & Hippisley-Cox, J. Protocol to assess risk of breast cancer associated with use of hormone replacement therapy in real world settings: two nested case-control studies in primary care

Hormone replacement therapy (HRT) is used to help women suffering from menopausal symptoms and reduce risk of osteoporosis. Although effective, the therapy may lead to an increased risk of breast cancer. Previous studies have not been powerful enou... Read More about Protocol to assess risk of breast cancer associated with use of hormone replacement therapy in real world settings: two nested case-control studies in primary care..

Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases (2019)
Journal Article
Vinogradova, Y., Coupland, C., & Hippisley-Cox, J. (2019). Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases. BMJ, 364, Article k4810. https://doi.org/10.1136/bmj.k4810

Objectives: To assess risk of venous thromboembolism associated with different types of hormone replacement therapy.

Design: Two nested case-control studies.

Setting: UK general practices contributing to QResearch or Clinical Practice Research... Read More about Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases.

Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care (2018)
Journal Article
Vinogradova, Y., Coupland, C., Hill, T., & Hippisley-Cox, J. (2018). Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care. BMJ, 362, Article k2505. https://doi.org/10.1136/bmj.k2505

Objective: To investigate the associations between direct oral anticoagulants (DOACs) and risks of bleeding, ischaemic stroke, venous thromboembolism, and all cause mortality compared with warfarin.

Design: Prospective open cohort study.

Settin... Read More about Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care.

Risk of bleeding with direct oral anticoagulants versus warfarin: cohort studies using primary care datasets (2018)
Journal Article
Vinogradova, Y., Coupland, C., & Hippisley-Cox, J. (2018). Risk of bleeding with direct oral anticoagulants versus warfarin: cohort studies using primary care datasets. British Journal of General Practice, 68(suppl 1), Article bjgp18X696629. https://doi.org/10.3399/bjgp18X696629

Background: There is limited evidence on the safety of direct oral anticoagulants (DOACs) in real world settings.

Aim: To investigate risks of bleeding and all-cause mortality in DOACs compared to warfarin.

Method: Prospective cohorts of incide... Read More about Risk of bleeding with direct oral anticoagulants versus warfarin: cohort studies using primary care datasets.