All Outputs (159)

Identifying placebo responders and predictors of response in osteoarthritis: a protocol for individual patient data meta-analysis (2016)
Journal Article
Fu, Y., Persson, M. S., Bhattacharya, A., Goh, S.-L., Stocks, J., van Middelkoop, M., Bierma-Zeinstra, S. M., Walsh, D., Doherty, M., & Zhang, W. (2016). Identifying placebo responders and predictors of response in osteoarthritis: a protocol for individual patient data meta-analysis. Systematic Reviews, 5(1), Article 183. https://doi.org/10.1186/s13643-016-0362-x

Background: The management of osteoarthritis (OA) is unsatisfactory, as most treatments are not clinically effective over placebo and most drugs have considerable side effects. On average, 75 % of the analgesic effect from OA treatments in clinical t... Read More about Identifying placebo responders and predictors of response in osteoarthritis: a protocol for individual patient data meta-analysis.

Relative efficacy of topical non-steroidal anti-inflammatory drugs and topical capsaicin in osteoarthritis: protocol for an individual patient data meta-analysis (2016)
Journal Article
Persson, M. S., Fu, Y., Bhattacharya, A., Goh, S.-L., Middelkoop, M. V., Bierma-Zeinstra, S. M., Walsh, D. A., Doherty, M., & Zhang, W. (2016). Relative efficacy of topical non-steroidal anti-inflammatory drugs and topical capsaicin in osteoarthritis: protocol for an individual patient data meta-analysis. Systematic Reviews, 5(1), Article 165. https://doi.org/10.1186/s13643-016-0348-8

Background

Pain is the most troubling issue to patients with osteoarthritis (OA), yet current pharmacological treatments offer only small-to-moderate pain reduction. Current guidelines therefore emphasise the need to identify predictors of treatme... Read More about Relative efficacy of topical non-steroidal anti-inflammatory drugs and topical capsaicin in osteoarthritis: protocol for an individual patient data meta-analysis.

Relative efficacy of different types of exercise for treatment of knee and hip osteoarthritis: Protocol for network meta-analysis of randomised controlled trials (2016)
Journal Article
Goh, S.-L., Persson, M., Bhattacharya, A., Hall, M. C., Doherty, M., & Zhang, W. (2016). Relative efficacy of different types of exercise for treatment of knee and hip osteoarthritis: Protocol for network meta-analysis of randomised controlled trials. Systematic Reviews, 5(147), https://doi.org/10.1186/s13643-016-0321-6

Background: “Exercise” is universally recommended as a core treatment for knee and hip osteoarthritis (OA). However, there are very few head-to-head comparative trials to determine the relative efficacy between different types of exercise. The aim of... Read More about Relative efficacy of different types of exercise for treatment of knee and hip osteoarthritis: Protocol for network meta-analysis of randomised controlled trials.

Early clinical features in Systemic Lupus Erythematosus: can they be used to achieve earlier diagnosis?: a risk prediction model (2016)
Journal Article
Rees, F., Doherty, M., Lanyon, P., Davenport, G., Riley, R. D., Zhang, W., & Grainge, M. J. (2017). Early clinical features in Systemic Lupus Erythematosus: can they be used to achieve earlier diagnosis?: a risk prediction model. Arthritis Care and Research, 69(6), 833-841. https://doi.org/10.1002/acr.23021

OBJECTIVES: 1) To compare the primary care consulting behaviour prior to diagnosis of people with Systemic Lupus Erythematosus (SLE) with controls, 2) to develop and validate a risk prediction model to aid earlier SLE diagnosis.

METHODS: 1,739 in... Read More about Early clinical features in Systemic Lupus Erythematosus: can they be used to achieve earlier diagnosis?: a risk prediction model.

Functional outcome and complications following surgery for Dupuytren’s disease: a multi-centre cross-sectional study (2016)
Journal Article
Rodrigues, J., Zhang, W., Scammell, B. E., Chakrabarti, I., Russell, P., Fulllilove, S., Davidson, D., & Davis, T. (in press). Functional outcome and complications following surgery for Dupuytren’s disease: a multi-centre cross-sectional study. Journal of Hand Surgery (European Volume), https://doi.org/10.1177/1753193416660045

Variables associated with recurrent Dupuytren’s disease, or a ‘diathesis’, have been investigated, but those associated with functional outcome and complications are less well studied. Outcomes 1 or 5 years after an aponeurotomy, fasciectomy or derm... Read More about Functional outcome and complications following surgery for Dupuytren’s disease: a multi-centre cross-sectional study.

2016 updated EULAR evidence-based recommendations for the management of gout (2016)
Journal Article
Richette, P., Doherty, M. T., Pascual, E., Barskova, V., Becce, F., Castañeda-Sanabria, J., Coyfish, M., Guillo, S., Jansen, T. L., Janssens, H., Lioté, F., Mallen, C., Nuki, G., Perez-Ruiz, F., Pimentao, J., Punzi, L., Pywell, T., So, A., Tausche, A., Uhlig, T., …Bardin, T. (2017). 2016 updated EULAR evidence-based recommendations for the management of gout. Annals of the Rheumatic Diseases, 76(1), 29-42. https://doi.org/10.1136/annrheumdis-2016-209707

Background: New drugs and new evidence concerning the use of established treatments have become available since the publication of the first European League Against Rheumatism (EULAR) recommendations for the management of gout, in 2006. This situatio... Read More about 2016 updated EULAR evidence-based recommendations for the management of gout.

Burden of comorbidity in systemic lupus erythematosus in the UK, 1999–2012 (2016)
Journal Article
Rees, F., Doherty, M., Grainge, M., Lanyon, P., Davenport, G., & Zhang, W. (in press). Burden of comorbidity in systemic lupus erythematosus in the UK, 1999–2012. Arthritis Care and Research, 68(6), https://doi.org/10.1002/acr.22751

Objective: To estimate the comorbidity associated with systemic lupus erythematosus (SLE) in the UK during 1999–2012.

Methods: A retrospective cohort study using the UK Clinical Practice Research Datalink was conducted. Prevalent cases of SLE wer... Read More about Burden of comorbidity in systemic lupus erythematosus in the UK, 1999–2012.

Erosive and osteoarthritic structural progression in early rheumatoid arthritis (2016)
Journal Article
McWilliams, D. F., Marshall, M., Jayakumar, K., Doherty, S., Doherty, M., Zhang, W., Kiely, P. D., Young, A., & Walsh, D. A. (2016). Erosive and osteoarthritic structural progression in early rheumatoid arthritis. Rheumatology, 55(8), 1477-1488. https://doi.org/10.1093/rheumatology/kew197

OBJECTIVES: To investigate factors associated with joint damage in early RA, and how comorbid OA might influence patient assessment and outcomes. METHODS: Baseline radiographs of hands and feet from 512 participants in the Early RA Network cohort, an... Read More about Erosive and osteoarthritic structural progression in early rheumatoid arthritis.

Synovial changes detected by ultrasound in people with knee osteoarthritis – a meta-analysis of observational studies (2016)
Journal Article
Sarmanov, A., Hall, M. C., Moses, J., Doherty, M., & Zhang, W. (2016). Synovial changes detected by ultrasound in people with knee osteoarthritis – a meta-analysis of observational studies. Osteoarthritis and Cartilage, 24(8), 1376-1383. https://doi.org/10.1016/j.joca.2016.03.004

© 2016 The Authors Objectives To examine the prevalence of synovial effusion, synovial hypertrophy and positive Doppler signal (DS) detected by ultrasound (US) in people with knee osteoarthritis (OA) and/or knee pain compared to that in the general p... Read More about Synovial changes detected by ultrasound in people with knee osteoarthritis – a meta-analysis of observational studies.

Does flare trial design affect the effect size of non-steroidal anti-inflammatory drugs in symptomatic osteoarthritis? A systematic review and meta-analysis (2016)
Journal Article
Smith, T. O., Zou, K., Abdullah, N., Chen, X., Kingsbury, S. R., Doherty, M., Zhang, W., & Conaghan, P. G. (2016). Does flare trial design affect the effect size of non-steroidal anti-inflammatory drugs in symptomatic osteoarthritis? A systematic review and meta-analysis. Annals of the Rheumatic Diseases, 75(11), https://doi.org/10.1136/annrheumdis-2015-208823

Objectives: It is thought that the clinical trial benefits of oral non-steroidal anti-inflammatory drugs (NSAIDs) may relate to flare designs. The aim of this study was to examine the difference in NSAID (including cyclooxygenase-2 (COX-2) inhibitors... Read More about Does flare trial design affect the effect size of non-steroidal anti-inflammatory drugs in symptomatic osteoarthritis? A systematic review and meta-analysis.

Examination of overall treatment effect and the proportion attributable to contextual effect in osteoarthritis: meta-analysis of randomised controlled trials (2016)
Journal Article
Zou, K., Wong, J., Abdullah, N., Chen, X., Smith, T., Doherty, M., & Zhang, W. (2016). Examination of overall treatment effect and the proportion attributable to contextual effect in osteoarthritis: meta-analysis of randomised controlled trials. Annals of the Rheumatic Diseases, 75(11), 1964-1970. https://doi.org/10.1136/annrheumdis-2015-208387

Objective: To examine the overall treatment effect and the proportion attributable to contextual effect (PCE) in randomised controlled trials (RCTs) of diverse treatments for osteoarthritis (OA).
Methods: We searched Medline, Embase, Central, Scienc... Read More about Examination of overall treatment effect and the proportion attributable to contextual effect in osteoarthritis: meta-analysis of randomised controlled trials.

Mortality in systemic lupus erythematosus in the United Kingdom 1999-2012 (2016)
Journal Article
Rees, F., Doherty, M., Grainge, M. J., Lanyon, P., Davenport, G., & Zhang, W. (2016). Mortality in systemic lupus erythematosus in the United Kingdom 1999-2012. Rheumatology, 55(5), 854-860. https://doi.org/10.1093/rheumatology/kev424

OBJECTIVES: To estimate the mortality associated with SLE during the period 1999-2012 by age, gender and region; and to ascertain the cause of death for people with SLE.

METHODS: A retrospective cohort study using the UK Clinical Practice Research... Read More about Mortality in systemic lupus erythematosus in the United Kingdom 1999-2012.

Impact of gout on the risk of atrial fibrillation (2015)
Journal Article
Kuo, C.-F., Grainge, M. J., Mallen, C., Zhang, W., & Doherty, M. (2016). Impact of gout on the risk of atrial fibrillation. Rheumatology, 55(4), 721-728. https://doi.org/10.1093/rheumatology/kev418

OBJECTIVES: To examine the risk of atrial fibrillation (AF) at the time of first diagnosis of gout compared with matched controls and to follow incident gout patients and their matched controls after diagnosis to compare their subsequent risk of AF.... Read More about Impact of gout on the risk of atrial fibrillation.

Comorbidities in patients with gout prior to and following diagnosis: case-control study (2015)
Journal Article
Kuo, C.-F., Grainge, M. J., Mallen, C., Zhang, W., & Doherty, M. (2016). Comorbidities in patients with gout prior to and following diagnosis: case-control study. Annals of the Rheumatic Diseases, 75(1), https://doi.org/10.1136/annrheumdis-2014-206410

OBJECTIVES: To determine the burden of comorbidities in patients with gout at diagnosis and the risk of developing new comorbidities post diagnosis.

METHODS: There were 39 111 patients with incident gout and 39 111 matched controls identified fro... Read More about Comorbidities in patients with gout prior to and following diagnosis: case-control study.

Validity of the disabilities of the Arm, Shoulder and Hand patient-reported outcome measure (DASH) and the Quickdash when used in Dupuytren’s disease (2015)
Journal Article
Rodrigues, J., Zhang, W., Scammell, B. E., Russell, P., Chakrabarti, I., Fullilove, S., Davidson, D., & Davis, T. (2016). Validity of the disabilities of the Arm, Shoulder and Hand patient-reported outcome measure (DASH) and the Quickdash when used in Dupuytren’s disease. Journal of Hand Surgery (European Volume), 41(6), https://doi.org/10.1177/1753193415601350

This study investigated aspects of the validity and reliability of the 30-item Disabilities of the Arm, Shoulder and Hand patient-reported outcome measure (DASH) and its relationship with the shorter 11-item QuickDASH in patients with Dupuytren’s dis... Read More about Validity of the disabilities of the Arm, Shoulder and Hand patient-reported outcome measure (DASH) and the Quickdash when used in Dupuytren’s disease.

Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families (2015)
Journal Article
Kuo, C.-F., Grainge, M. J., Valdes, A. M., See, L.-C., Luo, S.-F., Yu, K.-H., Zhang, W., & Doherty, M. (2015). Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families. JAMA Internal Medicine, 175(9), 1518-1526. https://doi.org/10.1001/jamainternmed.2015.3528

IMPORTANCE: Relatives of patients with systemic lupus erythematosus (SLE) appear to be at higher risk of SLE and other autoimmune diseases, but estimates of individual familial risks are largely unavailable or unreliable. Furthermore, relative contri... Read More about Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families.

Effect of allopurinol on all-cause mortality in adults with incident gout: propensity score–matched landmark analysis (2015)
Journal Article
Kuo, C.-F., Grainge, M. J., Mallen, C., Zhang, W., & Doherty, M. (2015). Effect of allopurinol on all-cause mortality in adults with incident gout: propensity score–matched landmark analysis. Rheumatology, 54(12), https://doi.org/10.1093/rheumatology/kev246

Objective: To examine the association between allopurinol use and all-cause mortality for patients with incident gout.

Methods: We compared all-cause mortality in incident gout patients who received allopurinol for at least 6 months within the exp... Read More about Effect of allopurinol on all-cause mortality in adults with incident gout: propensity score–matched landmark analysis.

Global epidemiology of gout: prevalence, incidence and risk factors (2015)
Journal Article
Kuo, C.-F., Grainge, M. J., Zhang, W., & Doherty, M. (2015). Global epidemiology of gout: prevalence, incidence and risk factors. Nature Reviews Rheumatology, 11(11), 649-662. https://doi.org/10.1038/nrrheum.2015.91

Gout is a crystal-deposition disease that results from chronic elevation of uric acid levels above the saturation point for monosodium urate (MSU) crystal formation. Initial presentation is mainly severely painful episodes of peripheral joint synovit... Read More about Global epidemiology of gout: prevalence, incidence and risk factors.

Familial risk of Sjögren's syndrome and co-aggregation of autoimmune diseases in affected families: a nationwide population study (2015)
Journal Article
Kuo, C.-F., Grainge, M. J., Valdes, A. M., See, L.-C., Luo, S.-F., Yu, K.-H., Zhang, W., & Doherty, M. (2015). Familial risk of Sjögren's syndrome and co-aggregation of autoimmune diseases in affected families: a nationwide population study. Arthritis and Rheumatology, 67(7), 1904-1912. https://doi.org/10.1002/art.39127

Objective: To investigate familial aggregation of Sjögren's syndrome (SS) and the relative risks (RRs) of other autoimmune disease in relatives of patients with SS.
Methods: We identified 23,658,577 beneficiaries enrolled in the Taiwan National Hea... Read More about Familial risk of Sjögren's syndrome and co-aggregation of autoimmune diseases in affected families: a nationwide population study.

Beer and wine consumption and risk of knee or hip osteoarthritis: a case control study (2015)
Journal Article
Muthuri, S. G., Zhang, W., Maciewicz, R. A., Muir, K., & Doherty, M. (2015). Beer and wine consumption and risk of knee or hip osteoarthritis: a case control study. Arthritis Research and Therapy, 17(1), 23. https://doi.org/10.1186/s13075-015-0534-4

© 2015 Muthuri et al.; licensee BioMed Central. Introduction: The aim of this study was to investigate the association between alcoholic and non-alcoholic beverages and knee or hip osteoarthritis (OA). Methods: We conducted a case-control study of Ca... Read More about Beer and wine consumption and risk of knee or hip osteoarthritis: a case control study.