All Outputs (10)

d-Xylose oxetane copolymers as bioderived and tuneable polyesters for amorphous solid dispersions (2024)
Journal Article
F. Clark, E., Howard, A., D. Morales Feliu, S., F. McCabe, J., C. Burley, J., Taresco, V., & Buchard, A. (2024). d-Xylose oxetane copolymers as bioderived and tuneable polyesters for amorphous solid dispersions. RSC Applied Polymers, https://doi.org/10.1039/D4LP00203B

The ring-opening copolymerisation of cyclic anhydrides with an oxetane derived from natural monosaccharide D-xylose has been used to synthesise fully biobased water soluble polyesters, which are able to stabilise the amorphous phases of nifedipine an... Read More about d-Xylose oxetane copolymers as bioderived and tuneable polyesters for amorphous solid dispersions.

Reactive prodrug strategy for addictive manufactured controlled release devices (2024)
Presentation / Conference Contribution
Di, M., Cuzzucoli Crucitti, V., Krumins, E., Lion, A., Wildman, R., Taresco, V., & He, Y. (2024, August). Reactive prodrug strategy for addictive manufactured controlled release devices. Paper presented at International Conference on Computational & Experimental Engineering and Sciences 2024, Singapore

Sustainable, upscaled synthesis of pinene-derived (meth)acrylates and their application as high Tg monomers in styrene/acrylic-based bioderived copolymer coatings (2024)
Journal Article
Pin-Nó, M., L. Jacob, P., Taresco, V., Kastelijn, M., Nabuurs, T., Surti, C., Bilney, J., Daly, J., J. Keddie, D., M. Howdle, S., & A. Stockman, R. (2024). Sustainable, upscaled synthesis of pinene-derived (meth)acrylates and their application as high Tg monomers in styrene/acrylic-based bioderived copolymer coatings. RSC Sustainability, 2(9), 2515-2523. https://doi.org/10.1039/D4SU00210E

n improved synthesis of the pinene-derived monomers (3-pinanyl acrylate 1 and 3-pinanyl methacrylate 2), replacing hazardous and/or expensive reagents from established methods with cheaper, more innocuous and sustainable reagents, is reported; the mo... Read More about Sustainable, upscaled synthesis of pinene-derived (meth)acrylates and their application as high Tg monomers in styrene/acrylic-based bioderived copolymer coatings.

Enabling high-fidelity personalised pharmaceutical tablets through multimaterial inkjet 3D printing with a water-soluble excipient (2024)
Journal Article
Rivers, G., Lion, A., Putri, N. R. E., Rance, G. A., Moloney, C., Taresco, V., …He, Y. (2024). Enabling high-fidelity personalised pharmaceutical tablets through multimaterial inkjet 3D printing with a water-soluble excipient. Materials Today Advances, 22, Article 100493. https://doi.org/10.1016/j.mtadv.2024.100493

Additive manufacturing offers manufacture of personalised pharmaceutical tablets through design freedoms and material deposition control at an individual voxel level. This control goes beyond geometry and materials choices: inkjet based 3D printing e... Read More about Enabling high-fidelity personalised pharmaceutical tablets through multimaterial inkjet 3D printing with a water-soluble excipient.

Multiple drug-delivery strategies to enhance the pharmacological and toxicological properties of Mefenamic acid (2024)
Journal Article
Cristiano, C., Cavanagh, R. J., Cuzzucoli Crucitti, V., Moloney, C., Axioti, E., Dixon, E., …Rimoli, M. G. (2024). Multiple drug-delivery strategies to enhance the pharmacological and toxicological properties of Mefenamic acid. Biomedicine and Pharmacotherapy, 175, Article 116647. https://doi.org/10.1016/j.biopha.2024.116647

Objective: To improve the biological and toxicological properties of Mefenamic acid (MA), the galactosylated prodrug of MA named MefeGAL was included in polymeric solid dispersions (PSs) composed of poly(glycerol adipate) (PGA) and Pluronic® F68 (Mef... Read More about Multiple drug-delivery strategies to enhance the pharmacological and toxicological properties of Mefenamic acid.

A facile one step route that introduces functionality to polymer powders for laser sintering (2024)
Journal Article
Krumins, E., Crawford, L. A., Rogers, D. M., Machado, F., Taresco, V., East, M., …Howdle, S. M. (2024). A facile one step route that introduces functionality to polymer powders for laser sintering. Nature Communications, 15(1), Article 3137. https://doi.org/10.1038/s41467-024-47376-4

Laser Sintering (LS) is a type of Additive Manufacturing (AM) exploiting laser processing of polymeric particles to produce 3D objects. Because of its ease of processability and thermo-physical properties, polyamide-12 (PA-12) represents ~95% of the... Read More about A facile one step route that introduces functionality to polymer powders for laser sintering.

Co-delivery of curcumin and resveratrol by folic acid-conjugated poly(glycerol adipate) nanoparticles for enhanced synergistic anticancer effect against osteosarcoma (2024)
Journal Article
Wongrakpanich, A., Bui Thi Thu, H., Sakchaisri, K., Taresco, V., Cuzzucoli Crucitti, V., Bunsupa, S., & Suksiriworapong, J. (2024). Co-delivery of curcumin and resveratrol by folic acid-conjugated poly(glycerol adipate) nanoparticles for enhanced synergistic anticancer effect against osteosarcoma. Journal of Drug Delivery Science and Technology, 95, Article 105610. https://doi.org/10.1016/j.jddst.2024.105610

This study explored the co-delivery of curcumin (CUR) and resveratrol (RV) using folic acid-conjugated poly(glycerol adipate)-based nanoparticles (FPPC NPs) to enhance their synergistic anticancer effects against osteosarcoma. Based on synergistic to... Read More about Co-delivery of curcumin and resveratrol by folic acid-conjugated poly(glycerol adipate) nanoparticles for enhanced synergistic anticancer effect against osteosarcoma.

Glycerol- and diglycerol-based polyesters: Evaluation of backbone alterations upon nano-formulation performance (2024)
Journal Article
Axioti, E., Dixon, E. G., Reynolds-Green, M., Alexander, E. C., Brugnoli, B., Keddie, D. J., …Taresco, V. (2024). Glycerol- and diglycerol-based polyesters: Evaluation of backbone alterations upon nano-formulation performance. Colloids and Surfaces B: Biointerfaces, 236, Article 113828. https://doi.org/10.1016/j.colsurfb.2024.113828

Despite the success of polyethylene glycol-based (PEGylated) polyesters in the drug delivery and biomedical fields, concerns have arisen regarding PEG's immunogenicity and limited biodegradability. In addition, inherent limitations, including limited... Read More about Glycerol- and diglycerol-based polyesters: Evaluation of backbone alterations upon nano-formulation performance.

Nanostructured Poly-l-lactide and Polyglycerol Adipate Carriers for the Encapsulation of Usnic Acid: A Promising Approach for Hepatoprotection (2024)
Journal Article
Brugnoli, B., Perna, G., Alfano, S., Piozzi, A., Galantini, L., Axioti, E., …Francolini, I. (2024). Nanostructured Poly-l-lactide and Polyglycerol Adipate Carriers for the Encapsulation of Usnic Acid: A Promising Approach for Hepatoprotection. Polymers, 16(3), Article 427. https://doi.org/10.3390/polym16030427

The present study investigates the utilization of nanoparticles based on poly-l-lactide (PLLA) and polyglycerol adipate (PGA), alone and blended, for the encapsulation of usnic acid (UA), a potent natural compound with various therapeutic properties... Read More about Nanostructured Poly-l-lactide and Polyglycerol Adipate Carriers for the Encapsulation of Usnic Acid: A Promising Approach for Hepatoprotection.

Glycerol-based sustainably sourced resin for volumetric printing (2024)
Journal Article
Krumins, E., Lentz, J. C., Sutcliffe, B., Sohaib, A., Jacob, P. L., Brugnoli, B., …Taresco, V. (2024). Glycerol-based sustainably sourced resin for volumetric printing. Green Chemistry, 26(3), 1345-1355. https://doi.org/10.1039/d3gc03607c

Volumetric Additive Manufacturing (VAM) represents a revolutionary advancement in the field of Additive Manufacturing, as it allows for the creation of objects in a single, cohesive process, rather than in a layer-by-layer approach. This innovative t... Read More about Glycerol-based sustainably sourced resin for volumetric printing.