All Outputs (59)

The Role of Extracellular Vesicles in Allergic Sensitization: A Systematic Review (2024)
Journal Article
Tucis, D., Hopkins, G., Browne, W., James, V., Onion, D., & Fairclough, L. C. (2024). The Role of Extracellular Vesicles in Allergic Sensitization: A Systematic Review. International Journal of Molecular Sciences, 25(8), Article 4492. https://doi.org/10.3390/ijms25084492

Allergies affect approximately 10–30% of people worldwide, with an increasing number of cases each year; however, the underlying mechanisms are still poorly understood. In recent years, extracellular vesicles (EVs) have been suggested to play a role... Read More about The Role of Extracellular Vesicles in Allergic Sensitization: A Systematic Review.

SnoRNAs in cardiovascular development, function, and disease (2024)
Journal Article
Chabronova, A., Holmes, T. L., Hoang, D. M., Denning, C., James, V., Smith, J. G. W., & Peffers, M. J. (2024). SnoRNAs in cardiovascular development, function, and disease. Trends in Molecular Medicine, 30(6), 562-578. https://doi.org/10.1016/j.molmed.2024.03.004

Small nucleolar RNAs (snoRNAs) are emerging as important regulators of cardiovascular (patho)biology. Several roles of snoRNAs have recently been identified in heart development and congenital heart diseases, as well as their dynamic regulation in hy... Read More about SnoRNAs in cardiovascular development, function, and disease.

Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles (2024)
Journal Article
Brown, T. J., Rutland, C. S., Rutland, C. S., Choi, K. K., Tse, F., Pfeffers, M. J., …James, V. (2024). Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles. Frontiers in Cell and Developmental Biology, 12, Article 1354606. https://doi.org/10.3389/fcell.2024.1354606

Prostate cancer (PCa) is a leading male malignancy worldwide, often progressing to bone metastasis, with limited curative options. Extracellular vesicles (EVs) have emerged as key players in cancer communication and metastasis, promoting the formatio... Read More about Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles.

Multi-Omic Temporal Landscape of Plasma and Synovial Fluid-Derived Extracellular Vesicles Using an Experimental Model of Equine Osteoarthritis (2023)
Journal Article
Anderson, J. R., Johnson, E., Jenkins, R., Jacobsen, S., Green, D., Walters, M., …Peffers, M. J. (2023). Multi-Omic Temporal Landscape of Plasma and Synovial Fluid-Derived Extracellular Vesicles Using an Experimental Model of Equine Osteoarthritis. International Journal of Molecular Sciences, 24(19), Article 14888. https://doi.org/10.3390/ijms241914888

Extracellular vesicles (EVs) contribute to osteoarthritis pathogenesis through their release into joint tissues and synovial fluid. Synovial fluid-derived EVs have the potential to be direct biomarkers in the causal pathway of disease but also enable... Read More about Multi-Omic Temporal Landscape of Plasma and Synovial Fluid-Derived Extracellular Vesicles Using an Experimental Model of Equine Osteoarthritis.

Small non-coding RNA landscape of extracellular vesicles from an experimental model of equine osteoarthritis (2023)
Presentation / Conference Contribution
Peffers, M., Anderson, J., Jacobsen, S., Walters, M., Bundgaard, L., Hackle, M., & James, V. (2023). Small non-coding RNA landscape of extracellular vesicles from an experimental model of equine osteoarthritis. Orthopaedic Proceedings, 105-B(SUPP_8), 119-119. https://doi.org/10.1302/1358-992x.2023.8.119

Joint tissues release extracellular vesicles (EVs) that potentially sustain joint homeostasis and contribute to osteoarthritis (OA) pathogenesis. EVs are putative novel therapeutics for OA, and transport biologically active molecules (including small... Read More about Small non-coding RNA landscape of extracellular vesicles from an experimental model of equine osteoarthritis.

PBMC-derived extracellular vesicles in a smoking-related inflammatory disease model (2023)
Journal Article
Gomez, N. E., James, V., Arkill, K. P., Nizamudeen, Z. A., Onion, D., & Fairclough, L. C. (2023). PBMC-derived extracellular vesicles in a smoking-related inflammatory disease model. European Journal of Immunology, 53(6), Article 2250143. https://doi.org/10.1002/eji.202250143

Extracellular vesicles (EVs) function as mediators of intercellular communication and as such influence the recipient cell function. EVs derived from immune cells can carry out many of the same functions as their parental cells, as they carry costimu... Read More about PBMC-derived extracellular vesicles in a smoking-related inflammatory disease model.

Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer (2023)
Journal Article
Lothion-Roy, J., Haigh, D. B., Harris, A. E., Metzler, V. M., Alsaleem, M., Toss, M. S., …Woodcock, C. L. (2023). Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer. Frontiers in Genetics, 13, Article 1096071. https://doi.org/10.3389/fgene.2022.1096071

N6-methyladenosine (m6A) is the most abundant internal mRNA modification and is dynamically regulated through distinct protein complexes that methylate, demethylate, and/or interpret the m6A modification. These proteins, and the m6A modification, are... Read More about Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer.

Handbook of Stem Cell Therapy (2022)
Book
Haider, K. H. (Ed.). (2022). Handbook of Stem Cell Therapy. Springer Nature Singapore. https://doi.org/10.1007/978-981-19-2655-6

The handbook comprehensively reviews the therapeutic potential of stem cells and stem cell secretome-based cell-free strategies in regenerative medicine. The chapters in section I and section II respectively discuss the diverse applications of mesenc... Read More about Handbook of Stem Cell Therapy.

Temporal extracellular vesicle protein changes following intraarticular treatment with integrin α10β1-selected mesenchymal stem cells in equine osteoarthritis (2022)
Journal Article
Clarke, E. J., Johnson, E., Caamaño Gutierrez, E., Andersen, C., Berg, L. C., Jenkins, R. E., …Peffers, M. J. (2022). Temporal extracellular vesicle protein changes following intraarticular treatment with integrin α10β1-selected mesenchymal stem cells in equine osteoarthritis. Frontiers in Veterinary Science, 9, Article 1057667. https://doi.org/10.3389/fvets.2022.1057667

Introduction: Equine osteoarthritis (OA) is a heterogeneous, degenerative disease of the musculoskeletal system with multifactorial causation, characterized by a joint metabolic imbalance. Extracellular vesicles are nanoparticles involved in intracel... Read More about Temporal extracellular vesicle protein changes following intraarticular treatment with integrin α10β1-selected mesenchymal stem cells in equine osteoarthritis.

Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer (2022)
Journal Article
Harris, A. E., Metzler, V. M., Lothion-Roy, J., Varun, D., Woodcock, C. L., Haigh, D. B., …Jeyapalan, J. N. (2022). Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer. Frontiers in Endocrinology, 13, Article 1006101. https://doi.org/10.3389/fendo.2022.1006101

Androgen deprivation therapies (ADTs) are important treatments which inhibit androgen-induced prostate cancer (PCa) progression by either preventing androgen biosynthesis (e.g. abiraterone) or by antagonizing androgen receptor (AR) function (e.g. bic... Read More about Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer.

The role of extracellular vesicle miRNAs and tRNAs in synovial fibroblast senescence (2022)
Journal Article
Wijesinghe, S. N., Anderson, J., Brown, T. J., Nanus, D. E., Housmans, B., Green, J. A., …Peffers, M. J. (2022). The role of extracellular vesicle miRNAs and tRNAs in synovial fibroblast senescence. Frontiers in Molecular Biosciences, 9, Article 971621. https://doi.org/10.3389/fmolb.2022.971621

Extracellular vesicles are mediators of intercellular communication with critical roles in cellular senescence and ageing. In arthritis, senescence is linked to the activation of a pro-inflammatory phenotype contributing to chronic arthritis pathogen... Read More about The role of extracellular vesicle miRNAs and tRNAs in synovial fibroblast senescence.

Optical photothermal infrared spectroscopy can differentiate equine osteoarthritic plasma extracellular vesicles from healthy controls (2022)
Journal Article
Clarke, E. J., Lima, C., Anderson, J. R., Castanheira, C., Beckett, A., James, V., …Peffers, M. J. (2022). Optical photothermal infrared spectroscopy can differentiate equine osteoarthritic plasma extracellular vesicles from healthy controls. Analytical Methods, 14(37), 3661-3670. https://doi.org/10.1039/d2ay00779g

Equine osteoarthritis is a chronic degenerative disease of the articular joint, characterised by cartilage degradation resulting in pain and reduced mobility and thus is a prominent equine welfare concern. Diagnosis is usually at a late stage through... Read More about Optical photothermal infrared spectroscopy can differentiate equine osteoarthritic plasma extracellular vesicles from healthy controls.

Small non-coding RNA landscape of extracellular vesicles from a post-traumatic model of equine osteoarthritis (2022)
Journal Article
Anderson, J. R., Jacobsen, S., Walters, M., Bundgaard, L., Diendorfer, A., Hackl, M., …Peffers, M. J. (2022). Small non-coding RNA landscape of extracellular vesicles from a post-traumatic model of equine osteoarthritis. Frontiers in Veterinary Science, 9, Article 901269. https://doi.org/10.3389/fvets.2022.901269

Extracellular vesicles comprise an as yet inadequately investigated intercellular communication pathway in the field of early osteoarthritis. We hypothesised that the small non-coding RNA expression pattern in synovial fluid and plasma would change d... Read More about Small non-coding RNA landscape of extracellular vesicles from a post-traumatic model of equine osteoarthritis.

Impact of COVID-19 on student attainment and pedagogical needs when undertaking independent scientific research (2022)
Journal Article
Jeyapalan, J. N., James, V., Gardner, D. S., Lothion-Roy, J. H., Mongan, N. P., & Rutland, C. S. (2022). Impact of COVID-19 on student attainment and pedagogical needs when undertaking independent scientific research. Anatomia, Histologia, Embryologia, https://doi.org/10.1111/ahe.12842

Research is often an essential component of completing a veterinary medicine degree, with universities worldwide aiming to teach students a variety of techniques and general research comprehension and skills. As universities worldwide navigated the C... Read More about Impact of COVID-19 on student attainment and pedagogical needs when undertaking independent scientific research.

Epithelial to mesenchymal transition influences fibroblast phenotype in colorectal cancer by altering miR-200 levels in extracellular vesicles (2022)
Journal Article
Bhome, R., Emaduddin, M., James, V., House, L. M., Thirdborough, S. M., Mellone, M., …Sayan, A. E. (2022). Epithelial to mesenchymal transition influences fibroblast phenotype in colorectal cancer by altering miR-200 levels in extracellular vesicles. Journal of Extracellular Vesicles, 11(5), Article e12226. https://doi.org/10.1002/jev2.12226

Colorectal cancer (CRC) with a mesenchymal gene expression signature has the greatest propensity for distant metastasis and is characterised by the accumulation of cancer-associated fibroblasts in the stroma. We investigated whether the epithelial to... Read More about Epithelial to mesenchymal transition influences fibroblast phenotype in colorectal cancer by altering miR-200 levels in extracellular vesicles.

Extracellular Vesicles Derived from Mesenchymal Stem Cells: Biological Activity and Approaches of Large-Scale Production (2022)
Book Chapter
Gomzikova, M. O., James, V., & Rizvanov, A. A. (2022). Extracellular Vesicles Derived from Mesenchymal Stem Cells: Biological Activity and Approaches of Large-Scale Production. In K. H. Haider (Ed.), Handbook of stem cell therapy. Springer Singapore. https://doi.org/10.1007/978-981-16-6016-0_48-1

The discovery of extracellular vesicles has provided an outstanding breakthrough in stem cells and regenerative medicine. It has been shown that cells can transfer information through the secretion of soluble factors, the formation of direct physical... Read More about Extracellular Vesicles Derived from Mesenchymal Stem Cells: Biological Activity and Approaches of Large-Scale Production.

Extracellular vesicles and chronic obstructive pulmonary disease (COPD): a systematic review (2022)
Journal Article
Gomez, N., James, V., Onion, D., & Fairclough, L. C. (2022). Extracellular vesicles and chronic obstructive pulmonary disease (COPD): a systematic review. Respiratory Research, 23, Article 82. https://doi.org/10.1186/s12931-022-01984-0

Background: Chronic Obstructive Pulmonary Disease (COPD) is a common inflammatory disease of the airways characterized by irreversible airflow limitation, ranking the third highest cause of death worldwide. Extracellular vesicles (EVs) are important... Read More about Extracellular vesicles and chronic obstructive pulmonary disease (COPD): a systematic review.

Increasing Severity of Spinal Cord Injury Results in Microglia/Macrophages With Annular-Shaped Morphology and No Change in Expression of CD40 and Tumor Growth Factor-β During the Chronic Post-injury Stage (2022)
Journal Article
Akhmetzyanova, E. R., Timofeeva, A. V., Sabirov, D. K., Kostennikov, A. A., Rogozhin, A. A., James, V., …Mukhamedshina, Y. O. (2022). Increasing Severity of Spinal Cord Injury Results in Microglia/Macrophages With Annular-Shaped Morphology and No Change in Expression of CD40 and Tumor Growth Factor-β During the Chronic Post-injury Stage. Frontiers in Molecular Neuroscience, 14, Article 802558. https://doi.org/10.3389/fnmol.2021.802558

Determination of the quantitative composition of phenotypically and morphologically different populations of resident microglia and infiltrating macrophages in spinal cord injury (SCI) of various degrees of severity could lead to much needed novel th... Read More about Increasing Severity of Spinal Cord Injury Results in Microglia/Macrophages With Annular-Shaped Morphology and No Change in Expression of CD40 and Tumor Growth Factor-β During the Chronic Post-injury Stage.

Cellular and Molecular Gradients in the Ventral Horns With Increasing Distance From the Injury Site After Spinal Cord Contusion (2022)
Journal Article
Kabdesh, I. M., Mukhamedshina, Y. O., Arkhipova, S. S., Sabirov, D. K., Kuznecov, M. S., Vyshtakalyuk, A. B., …Chelyshev, Y. A. (2022). Cellular and Molecular Gradients in the Ventral Horns With Increasing Distance From the Injury Site After Spinal Cord Contusion. Frontiers in Cellular Neuroscience, 16, Article 817752. https://doi.org/10.3389/fncel.2022.817752

To identify cellular and molecular gradients following spinal cord injury (SCI), a rat contusion model of severe SCI was used to investigate the expression of NG2 and molecules that identify astrocytes and axons of the ventral horns (VH) at different... Read More about Cellular and Molecular Gradients in the Ventral Horns With Increasing Distance From the Injury Site After Spinal Cord Contusion.

The Study of Cerebrospinal Fluid microRNAs in Spinal Cord Injury and Neurodegenerative Diseases: Methodological Problems and Possible Solutions (2021)
Journal Article
Baichurina, I., Valiullin, V., James, V., Rizvanov, A., & Mukhamedshina, Y. (2021). The Study of Cerebrospinal Fluid microRNAs in Spinal Cord Injury and Neurodegenerative Diseases: Methodological Problems and Possible Solutions. International Journal of Molecular Sciences, 23(1), Article 114. https://doi.org/10.3390/ijms23010114

Despite extensive research on neurological disorders, unanswered questions remain regarding the molecular mechanisms underpinning the course of these diseases, and the search continues for effective biomarkers for early diagnosis, prognosis, or thera... Read More about The Study of Cerebrospinal Fluid microRNAs in Spinal Cord Injury and Neurodegenerative Diseases: Methodological Problems and Possible Solutions.