All Outputs (4)

Atlas registration for edema-corrected MRI lesion volume in mouse stroke models (2017)
Journal Article
Koch, S., Mueller, S., Foddis, M., Bienert, T., von Elverfeldt, D., Knab, F., …Boehm-Sturm, P. (in press). Atlas registration for edema-corrected MRI lesion volume in mouse stroke models. Journal of Cerebral Blood Flow and Metabolism, https://doi.org/10.1177/0271678X17726635

Lesion volume measurements with magnetic resonance imaging are widely used to assess outcome in rodent models of stroke. In this study, we improved a mathematical framework to correct lesion size for edema which is based on manual delineation of the... Read More about Atlas registration for edema-corrected MRI lesion volume in mouse stroke models.

Increased homocysteine levels impair reference memory and reducecortical levels of acetylcholine in a mouse model of vascular cognitive impairment (2017)
Journal Article
Dam, K., Füchtemeier, M., Farr, T. D., Boehm-Sturm, P., Foddis, M., Dirnagl, U., …Jadavji, N. M. (2017). Increased homocysteine levels impair reference memory and reducecortical levels of acetylcholine in a mouse model of vascular cognitive impairment. Behavioural Brain Research, 321, https://doi.org/10.1016/j.bbr.2016.12.041

Folates are B-vitamins that are vital for normal brain function. Deficiencies in folates either genetic(methylenetetrahydrofolate reductase, MTHFR) or dietary intake of folic acid result in elevated levelsof homocysteine. Clinical studies have shown... Read More about Increased homocysteine levels impair reference memory and reducecortical levels of acetylcholine in a mouse model of vascular cognitive impairment.

Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke (2017)
Journal Article
Ahmed, J., Dwyer, D. E., Farr, T. D., Harrison, D. J., Dunnett, S. B., & Trueman, R. C. (in press). Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke. Journal of Cerebral Blood Flow and Metabolism, 37(3), https://doi.org/10.1177/0271678X16684141

The need for sensitive, easy to administer assessments of long-term functional deficits is crucial in pre-clinical stroke research. In the present study, we introduce lickometry (lick microstructure analysis) as a precise method to assess sensorimoto... Read More about Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke.

Recent progress in translational research on neurovascular and neurodegenerative disorders (2017)
Journal Article
Demuth, H.-U., Dijkhuizen, R. M., Farr, T. D., Gelderblom, M., Horsburgh, K., Iadecola, C., …Boltze, J. (2017). Recent progress in translational research on neurovascular and neurodegenerative disorders. Restorative Neurology and Neuroscience, 35(1), https://doi.org/10.3233/RNN-160690

The already established and widely used intravenous application of recombinant tissue plasminogen activator as a re-opening strategy for acute vessel occlusion in ischemic stroke was recently added by mechanical thrombectomy, representing a fundament... Read More about Recent progress in translational research on neurovascular and neurodegenerative disorders.