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All Outputs (45)

Brain Connectome Graphs based Machine Learning for Diagnosis of Alzheimer’s Disease (2024)
Journal Article
Chen, K., Weng, Y., Dening, T., Hosseini, A. A., & Zuo, G. (2024). Brain Connectome Graphs based Machine Learning for Diagnosis of Alzheimer’s Disease. Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 20(S1), Article e090237. https://doi.org/10.1002/alz.090237

Background

Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline and memory loss. Early and accurate diagnosis of AD is crucial for patient information, advance planning, and potentially effective... Read More about Brain Connectome Graphs based Machine Learning for Diagnosis of Alzheimer’s Disease.

Specialist clinical pathways in audiology services for adults living with coexisting hearing loss and dementia: a scoping review protocol (2024)
Journal Article
Wenje, S. M., Calvert, S., Henshaw, H., Spriggs, R. V., Dening, T., Hendron, E., & Heffernan, E. (2024). Specialist clinical pathways in audiology services for adults living with coexisting hearing loss and dementia: a scoping review protocol. BMJ Open, 14(12), Article e087418. https://doi.org/10.1136/bmjopen-2024-087418

Introduction Both hearing loss and dementia are associated with ageing, and it is thought that many individuals living with dementia also live with hearing loss. Despite the large comorbidity between these two disorders, there remains a clear lack of... Read More about Specialist clinical pathways in audiology services for adults living with coexisting hearing loss and dementia: a scoping review protocol.

A multi-view learning approach with diffusion model to synthesize FDG PET from MRI T1WI for diagnosis of Alzheimer's disease (2024)
Journal Article
Chen, K., Weng, Y., Huang, Y., Zhang, Y., Dening, T., Hosseini, A. A., & Xiao, W. (2024). A multi-view learning approach with diffusion model to synthesize FDG PET from MRI T1WI for diagnosis of Alzheimer's disease. Alzheimer's & Dementia: The Journal of the Alzheimer's Association, https://doi.org/10.1002/alz.14421

INTRODUCTION

This study presents a novel multi-view learning approach for machine learning (ML)–based Alzheimer's disease (AD) diagnosis.

METHODS

A diffusion model is proposed to synthesize the fluorodeoxyglucose positron emission tomography... Read More about A multi-view learning approach with diffusion model to synthesize FDG PET from MRI T1WI for diagnosis of Alzheimer's disease.

Dementia and the Deaf community: prevalence, assessment and management in people with hearing loss since childhood (2024)
Journal Article
Flower, I., Heffernan, E., & Dening, T. (2024). Dementia and the Deaf community: prevalence, assessment and management in people with hearing loss since childhood. Aging and Mental Health, https://doi.org/10.1080/13607863.2024.2430533

Objectives
Deaf people face complex challenges in accessing healthcare, particularly for age-related conditions, yet the Deaf community is largely overlooked in dementia research. This study explores healthcare issues in relation to dementia for ol... Read More about Dementia and the Deaf community: prevalence, assessment and management in people with hearing loss since childhood.

Risk of dementia associated with anticholinergic drugs for overactive bladder in adults aged ≥55 years: nested case-control study (2024)
Journal Article
Iyen, B., Coupland, C., Bell, B., Orrell, M., Dening, T., & Avery, T. (2024). Risk of dementia associated with anticholinergic drugs for overactive bladder in adults aged ≥55 years: nested case-control study. BMJ Medicine, 3(1), Article e000799. https://doi.org/10.1136/bmjmed-2023-000799

Objective To investigate whether different anticholinergic drug treatments for overactive bladder have differential risks for incident dementia, in a large representative population of older adults in England.

Design Nested case-control study.... Read More about Risk of dementia associated with anticholinergic drugs for overactive bladder in adults aged ≥55 years: nested case-control study.

Humans: an integrative review exploring dehumanisation in advanced dementia (2024)
Journal Article
Bøgmose, J., Olivares Bøgeskov, B. M., Dening, T., & Martinsen, B. (2024). Humans: an integrative review exploring dehumanisation in advanced dementia. Nursing Ethics, https://doi.org/10.1177/09697330241277989

Background: People living with advanced dementia risk being seen as someone without personhood in contemporary societies, an understanding that has been described and challenged for decades in dementia scholarly literature. Such perception can be cha... Read More about Humans: an integrative review exploring dehumanisation in advanced dementia.

Integrated Physical‐Mental Healthcare Services in Specialist Settings to Improve Outcomes for Older People Living With Mental Health Diagnoses: A Systematic Review (2024)
Journal Article
Beishon, L., Hickey, B., Desai, B., Chithiramohan, T., Evley, R., Subramaniam, H., Maniatopoulos, G., Rajkumar, A. P., Dening, T., Mukateova‐Ladinska, E., Robinson, T. G., & Tarrant, C. (2024). Integrated Physical‐Mental Healthcare Services in Specialist Settings to Improve Outcomes for Older People Living With Mental Health Diagnoses: A Systematic Review. International Journal of Geriatric Psychiatry, 39(9), Article e6146. https://doi.org/10.1002/gps.6146

Background
Many older people are now living with co-occurring physical and mental health disorders, but these often managed separately. The aim of this systematic review was to explore integrated physical-mental health care services available intern... Read More about Integrated Physical‐Mental Healthcare Services in Specialist Settings to Improve Outcomes for Older People Living With Mental Health Diagnoses: A Systematic Review.

Categorising interventions to enhance vaccine uptake or reduce vaccine hesitancy in the United Kingdom: A systematic review and meta-analysis (2024)
Journal Article
Kafadar, A. H., Sabatini, S., Jones, K. A., & Dening, T. (2024). Categorising interventions to enhance vaccine uptake or reduce vaccine hesitancy in the United Kingdom: A systematic review and meta-analysis. Vaccine, 42(25), Article 126092. https://doi.org/10.1016/j.vaccine.2024.06.059

Background: Vaccination is one of the most important public health interventions to combat infectious disease. However, vaccine hesitancy prevents us reaching the global target of vaccine uptake (e.g., 75 % of influenza vaccination in at-risk groups)... Read More about Categorising interventions to enhance vaccine uptake or reduce vaccine hesitancy in the United Kingdom: A systematic review and meta-analysis.

An alternative theoretical approach to develop a new conception about pain in people with dementia (2024)
Journal Article
Morgner, C., Dening, K. H., Dening, T., & Gibson, B. (2024). An alternative theoretical approach to develop a new conception about pain in people with dementia. Medical Humanities, 50(3), 545-554. https://doi.org/10.1136/medhum-2023-012718

The theoretical approach presented in this paper describes a novel experimental-theoretical methodology to conceptualise pain in people with dementia. Existing procedures for assessment of pain rely on subjective self-report using pain questionnaires... Read More about An alternative theoretical approach to develop a new conception about pain in people with dementia.

Transgender and gender diverse older people: health, aging and dementia (2024)
Journal Article
Asti, E., Beale, N., Thorne, N., & Dening, T. (2024). Transgender and gender diverse older people: health, aging and dementia. International Journal of Transgender Health, https://doi.org/10.1080/26895269.2024.2355232

Background and Objectives
262,000 people in the UK identify as transgender and gender diverse (TGD), and this population is believed to be growing. As the population is aging, an increase in older TGD people accessing health and social care can be a... Read More about Transgender and gender diverse older people: health, aging and dementia.

Semi-supervised information fusion for medical image analysis: Recent progress and future perspectives (2024)
Journal Article
Weng, Y., Zhang, Y., Wang, W., & Dening, T. (2024). Semi-supervised information fusion for medical image analysis: Recent progress and future perspectives. Information Fusion, 106, Article 102263. https://doi.org/10.1016/j.inffus.2024.102263

Supervised machine learning requires training on the dataset with annotation. However, fine-grained annotation is very expensive to acquire. In the medical image analysis domain, the sheer volume of data and lack of annotation limit the performance o... Read More about Semi-supervised information fusion for medical image analysis: Recent progress and future perspectives.

When Hearing Loss Co-occurs with Dementia: Challenges and Opportunities in Diagnosis and Management (2023)
Book Chapter
Broome, E., Burgon, C., Heffernan, E., Dening, T., Calvert, S., Rajasingam, S., & Henshaw, H. (2023). When Hearing Loss Co-occurs with Dementia: Challenges and Opportunities in Diagnosis and Management. In A. Ciorba, & S. Hatzopoulos (Eds.), Updates on Hearing Loss and its Rehabilitation (1-27). InTech. https://doi.org/10.5772/intechopen.1003179

Both dementia and hearing loss are highly prevalent in older adults and often coexist, increasing the complexity of diagnosis and management of both conditions. As the population ages, an increasing number of people will experience both long-term con... Read More about When Hearing Loss Co-occurs with Dementia: Challenges and Opportunities in Diagnosis and Management.

A comparative study of GNN and MLP based machine learning for the diagnosis of Alzheimer's Disease involving data synthesis. (2023)
Journal Article
Chen, K., Weng, Y., Hosseini, A. A., Dening, T., Zuo, G., & Zhang, Y. (2024). A comparative study of GNN and MLP based machine learning for the diagnosis of Alzheimer's Disease involving data synthesis. Neural Networks, 169, 442-452. https://doi.org/10.1016/j.neunet.2023.10.040

Alzheimer’s Disease (AD) is a neurodegenerative disease that commonly occurs in older people. It is characterized by both cognitive and functional impairment. However, as AD has an unclear pathological cause, it can be hard to diagnose with confidenc... Read More about A comparative study of GNN and MLP based machine learning for the diagnosis of Alzheimer's Disease involving data synthesis..

New horizons in hearing conditions (2023)
Journal Article
Henshaw, H., Calvert, S., Heffernan, E., Broome, E. E., Fackrell, K., Dening, T., & Burgon, C. (2023). New horizons in hearing conditions. Age and Ageing, 52(8), Article afad150. https://doi.org/10.1093/ageing/afad150

Hearing conditions such as hearing loss, tinnitus and hyperacusis are highly prevalent in the population and can severely impact communication and quality of life. Hearing is affected by multiple factors, including heredity, noise exposure, age, sex,... Read More about New horizons in hearing conditions.

Living Well with Dementia: Feeling Empowered through Interaction with Their Social Environment (2023)
Journal Article
Ziebuhr, B., Zanasi, M., Bueno Aguado, Y., Losada Durán, R., Dening, T., Tournier, I., Niedderer, K., Diaz, A., Druschke, D., Almeida, R., & Holthoff-Detto, V. (2023). Living Well with Dementia: Feeling Empowered through Interaction with Their Social Environment. International Journal of Environmental Research and Public Health, 20(12), Article 6080. https://doi.org/10.3390/ijerph20126080

This study was designed to advance our understanding of how feelings of empowerment in people living with dementia still residing at home can be promoted. We conducted qualitative interviews with 12 participants with mild-to-moderate stages of dement... Read More about Living Well with Dementia: Feeling Empowered through Interaction with Their Social Environment.

Care for older forensic mental health patients: A consensus guidance document (2023)
Journal Article
Tomlin, J., Walker, K., Yates, J., Dening, T., Goethals, K., Völlm, B., & Griffiths, C. (2023). Care for older forensic mental health patients: A consensus guidance document. European Psychiatry, 66(1), Article e44. https://doi.org/10.1192/j.eurpsy.2023.2413

Background
It is important to investigate the needs, experiences, and outcomes of older forensic mental health inpatients. In this consensus document, we offer practitioners working with older forensic inpatients recommendations to meet the unique o... Read More about Care for older forensic mental health patients: A consensus guidance document.

Exploring factors influencing willingness of older adults to use assistive technologies: evidence from the cognitive function and ageing study II (2023)
Journal Article
Begde, A., Jain, M., Goodwin, M., Brayne, C., Barnes, L., Brooks, R., Green, E., Richardson, C., Dening, T., Wilcockson, T., & Hogervorst, E. (2024). Exploring factors influencing willingness of older adults to use assistive technologies: evidence from the cognitive function and ageing study II. Information, Communication and Society, 27(2), 368-385. https://doi.org/10.1080/1369118X.2023.2205915

Technology is widely promoted as a solution to greater independence and better health for the rapidly growing UK older population. If this is to be realised, we need to understand barriers and facilitators to uptake and investigate who wants this tec... Read More about Exploring factors influencing willingness of older adults to use assistive technologies: evidence from the cognitive function and ageing study II.

Quality of life, wellbeing, recovery, and progress for older forensic mental health patients: a qualitative investigation based on the perspectives of patients and staff (2023)
Journal Article
Walker, K., Yates, J., Dening, T., Völlm, B., Tomlin, J., & Griffiths, C. (2023). Quality of life, wellbeing, recovery, and progress for older forensic mental health patients: a qualitative investigation based on the perspectives of patients and staff. International Journal of Qualitative Studies on Health and Well-being, 18(1), Article 2202978. https://doi.org/10.1080/17482631.2023.2202978

Purpose
There is a lack of research informing service requirements for older (aged≥55 years) forensic mental health patients. The aim of this research was to increase knowledge about older forensic mental health patients’ quality of life, wellbeing,... Read More about Quality of life, wellbeing, recovery, and progress for older forensic mental health patients: a qualitative investigation based on the perspectives of patients and staff.