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Myosin heavy chain mRNA isoforms are expressed in two distinct cohorts during C2C12 myogenesis (2011)
Journal Article
Brown, D. M., Parr, T., & Brameld, J. M. (2012). Myosin heavy chain mRNA isoforms are expressed in two distinct cohorts during C2C12 myogenesis. Journal of Muscle Research and Cell Motility, 32(6), 383-390. https://doi.org/10.1007/s10974-011-9267-4

The regulation of muscle fibre transitions has mainly been studied in vivo using conventional histological or immunohistochemical techniques. In order to investigate the molecular regulation of myosin heavy chain (MyHC) isoform expression in cell cul... Read More about Myosin heavy chain mRNA isoforms are expressed in two distinct cohorts during C2C12 myogenesis.

Use of the Affymetrix human GeneChip array and genomic DNA hybridisation probe selection to study ovine transcriptomes (2011)
Journal Article
Graham, N. S., May, S. T., Daniel, Z. C., Emmerson, Z. F., Brameld, J. M., & Parr, T. (2011). Use of the Affymetrix human GeneChip array and genomic DNA hybridisation probe selection to study ovine transcriptomes. Animal, 5(6), 861-866. https://doi.org/10.1017/S1751731110002533

Affymetrix GeneChip microarrays are a powerful tool to study global gene expression profiles and have been used on many species. However, no sheep-specific Affymetrix GeneChip is currently available and the bovine array is fairly limited in its cover... Read More about Use of the Affymetrix human GeneChip array and genomic DNA hybridisation probe selection to study ovine transcriptomes.

Calpastatin is associated with lymphovascular invasion in breast cancer (2011)
Journal Article
Storr, S. J., Mohammed, R. A., Woolston, C. M., Green, A. R., Parr, T., Spiteri, I., …Martin, S. G. (2011). Calpastatin is associated with lymphovascular invasion in breast cancer. Breast, 20(5), 413-418. https://doi.org/10.1016/j.breast.2011.04.002

Metastasis of breast cancer is a major contributor to mortality. Histological assessment of vascular invasion (VI) provides important prognostic information and demonstrates that VI occurs predominantly via lymphatics in breast cancer. We sought to e... Read More about Calpastatin is associated with lymphovascular invasion in breast cancer.

The calpain system and cancer (2011)
Journal Article
Storr, S. J., Carragher, N. O., Frame, M. C., Parr, T., & Martin, S. G. (2011). The calpain system and cancer. Nature Reviews Cancer, 11(5), 364-374. https://doi.org/10.1038/nrc3050

The calpains are a conserved family of cysteine proteinases that catalyse the controlled proteolysis of many specific substrates. Calpain activity is implicated in several fundamental physiological processes, including cytoskeletal remodelling, cellu... Read More about The calpain system and cancer.

Regulation of ovine and porcine stearoyl coenzyme A desaturase gene promoters by fatty acids and sterols (2010)
Journal Article
Zulkifli, R. M., Parr, T., Salter, A. M., & Brameld, J. M. (2010). Regulation of ovine and porcine stearoyl coenzyme A desaturase gene promoters by fatty acids and sterols. Journal of Animal Science, 88(8), 2565-2575. https://doi.org/10.2527/jas.2009-2603

Stearoyl CoA desaturase (SCD) is responsible for converting SFA into MUFA and plays an important role in regulating the fatty acid composition of tissues. Although the number of SCD isoforms differs among species, SCD-1 is the predominant isoform exp... Read More about Regulation of ovine and porcine stearoyl coenzyme A desaturase gene promoters by fatty acids and sterols.

Examination of myosin heavy chain isoform expression in ovine skeletal muscles (2009)
Journal Article
Hemmings, K. M., Parr, T., Daniel, Z. C., Picard, B., Buttery, P. J., & Brameld, J. M. (2009). Examination of myosin heavy chain isoform expression in ovine skeletal muscles. Journal of Animal Science, 87(12), 3915-3922. https://doi.org/10.2527/jas.2009-2067

The contractile and associated metabolic characteristics of muscles are determined by their myosin heavy chain (MHC) isoform expression. In large mammals, the level of MHCIIB expression, which is associated with fast glycolytic-type muscle fibers, ha... Read More about Examination of myosin heavy chain isoform expression in ovine skeletal muscles.

Myosin heavy chain expression in ovine skeletal muscles (2009)
Presentation / Conference Contribution
Hemmings, K., Parr, T., Daniel, Z., Picard, B., Buttery, P., & Brameld, J. (2024, September). Myosin heavy chain expression in ovine skeletal muscles. Presented at XIth International Symposium on Ruminant Physiology, Clermont Ferrand

The effects of beta-adrenergic agonist (BA) and growth hormone (GH) on metabolic characteristics and factors involved in determining skeletal muscle fibre type in growing lambs (2009)
Presentation / Conference Contribution
Hemmings, K., Parr, T., Daniel, Z., Buttery, P., & Brameld, J. (2009, September). The effects of beta-adrenergic agonist (BA) and growth hormone (GH) on metabolic characteristics and factors involved in determining skeletal muscle fibre type in growing lambs. Presented at XIth International Symposium on Ruminant Physiology, Clermont Ferrand, France

The effect of maternal undernutrition before muscle differentiation on the muscle fiber development of the newborn lamb (2005)
Journal Article
Fahey, A. J., Brameld, J. M., Parr, T., & Buttery, P. J. (2005). The effect of maternal undernutrition before muscle differentiation on the muscle fiber development of the newborn lamb. Journal of Animal Science, 83(11), 2564-2571. https://doi.org/10.2527/2005.83112564x

There is a need to improve the lean tissue content of ruminant animals destined for meat production. Muscle fiber number is set during fetal development. The effect of undernutrition of pregnant ewes on subsequent muscle fiber characteristics of thei... Read More about The effect of maternal undernutrition before muscle differentiation on the muscle fiber development of the newborn lamb.

The effect of maternal undernutrition before muscle differentiation on the muscle fiber development of the newborn lamb (2005)
Journal Article
Fahey, A. J., Brameld, J. M., Parr, T., & Buttery, P. J. (2005). The effect of maternal undernutrition before muscle differentiation on the muscle fiber development of the newborn lamb. Journal of Animal Science, 83(11), 2564-2571. https://doi.org/10.2527/2005.83112564x

There is a need to improve the lean tissue content of ruminant animals destined for meat production. Muscle fiber number is set during fetal development. The effect of undernutrition of pregnant ewes on subsequent muscle fiber characteristics of thei... Read More about The effect of maternal undernutrition before muscle differentiation on the muscle fiber development of the newborn lamb.

Ontogeny of factors associated with proliferation and differentiation of muscle in the ovine fetus (2005)
Journal Article
Fahey, A. J., Brameld, J. M., Parr, T., & Buttery, P. J. (2005). Ontogeny of factors associated with proliferation and differentiation of muscle in the ovine fetus. Journal of Animal Science, 83(10), 2330-2338

The number of muscle fibers within a muscle has been found to be of high importance for the growth potential of an animal, and this number is set during fetal development. The objective of this study was to identify the ontogeny of muscle cell differ... Read More about Ontogeny of factors associated with proliferation and differentiation of muscle in the ovine fetus.

Ontogeny of factors associated with proliferation and differentiation of muscle in the ovine fetus (2005)
Journal Article
Fahey, A. J., Brameld, J. M., Parr, T., & Buttery, P. J. (2005). Ontogeny of factors associated with proliferation and differentiation of muscle in the ovine fetus. Journal of Animal Science, 83(10), 2330-2338. https://doi.org/10.2527/2005.83102330x

The number of muscle fibers within a muscle has been found to be of high importance for the growth potential of an animal, and this number is set during fetal development. The objective of this study was to identify the ontogeny of muscle cell differ... Read More about Ontogeny of factors associated with proliferation and differentiation of muscle in the ovine fetus.

Expression of calpastatin isoforms in muscle and functionality of multiple calpastatin promoters (2004)
Journal Article
Parr, T., Jewell, K. K., Sensky, P. L., Brameld, J. M., Bardsley, R. G., & Buttery, P. J. (2004). Expression of calpastatin isoforms in muscle and functionality of multiple calpastatin promoters. Archives of Biochemistry and Biophysics, 427(1), 8-15. https://doi.org/10.1016/j.abb.2004.04.001

Calpastatin is the specific endogenous inhibitor of calpain proteinase that is encoded by a single gene. Transient transfection assays in both a non-fusing skeletal muscle and non-muscle cell-line demonstrated that the putative porcine calpastatin pr... Read More about Expression of calpastatin isoforms in muscle and functionality of multiple calpastatin promoters.