All Outputs (88)

Obesity and type 2 diabetes are important risk factors underlying previously undiagnosed cirrhosis in general practice: a cross-sectional study using Transient Elastography (2017)
Journal Article
Harman, D. J., Ryder, S. D., James, M. W., Wilkes, E. A., Card, T. R., Aithal, G. P., & Guha, I. N. (2018). Obesity and type 2 diabetes are important risk factors underlying previously undiagnosed cirrhosis in general practice: a cross-sectional study using Transient Elastography. Alimentary Pharmacology and Therapeutics, 47(4), 504-515. https://doi.org/10.1111/apt.14463

Background: Rising cirrhosis incidence and mortality in the United Kingdom has been attributed predominantly to excess alcohol consumption. However, metabolic risk factors such as type 2 diabetes and obesity may also be important. Aim: To screen at-... Read More about Obesity and type 2 diabetes are important risk factors underlying previously undiagnosed cirrhosis in general practice: a cross-sectional study using Transient Elastography.

Venous thromboembolism and mortality in breast cancer: cohort study with systematic review and meta-analysis (2017)
Journal Article
Khan, U. T., Walker, A. J., Baig, S., Card, T. R., Kirwan, C. C., & Grainge, M. J. (2017). Venous thromboembolism and mortality in breast cancer: cohort study with systematic review and meta-analysis. BMC Cancer, 17(747), https://doi.org/10.1186/s12885-017-3719-1

Background Breast cancer patients are at an increased risk of venous thromboembolism (VTE). However, current evidence as to whether VTE increases the risk of mortality in breast cancer patients is conflicting. We present data from a large cohort of... Read More about Venous thromboembolism and mortality in breast cancer: cohort study with systematic review and meta-analysis.

The risk of Clostridium difficile infection in patients with pernicious anaemia: a retrospective cohort study using primary care database. (2017)
Journal Article
Othman, F., Crooks, C. J., & Card, T. R. (in press). The risk of Clostridium difficile infection in patients with pernicious anaemia: a retrospective cohort study using primary care database. United European Gastroenterology Journal, https://doi.org/10.1177/2050640617695697

Background: Studies have found an association between proton pump inhibitor (PPI) use and Clostridium difficile infection. The purpose of this study was to determine whether the mechanism by which PPIs induce an increased risk of C. difficile infecti... Read More about The risk of Clostridium difficile infection in patients with pernicious anaemia: a retrospective cohort study using primary care database..

Risk of hepatocellular carcinoma among individuals with different aetiologies of cirrhosis: a population-based cohort study (2017)
Journal Article
West, J., Card, T. R., Aithal, G. P., & Fleming, K. M. (2017). Risk of hepatocellular carcinoma among individuals with different aetiologies of cirrhosis: a population-based cohort study. Alimentary Pharmacology and Therapeutics, 45(7), 983-990. https://doi.org/10.1111/apt.13961

Background: Among patients with cirrhosis, only those determined to be at risk for hepatocellular carcinoma (HCC) should undergo surveillance. However, little is known about how different aetiologies of cirrhosis affect risk for HCC. Aim: To quantif... Read More about Risk of hepatocellular carcinoma among individuals with different aetiologies of cirrhosis: a population-based cohort study.

Community acquired pneumonia incidence before and after proton pump inhibitor prescription: population based study (2016)
Journal Article
Othman, F., Crooks, C. J., & Card, T. R. (2016). Community acquired pneumonia incidence before and after proton pump inhibitor prescription: population based study. BMJ, 355, Article i5813. https://doi.org/10.1136/bmj.i5813

Objective To examine the risk of community acquired pneumonia before and after prescription of proton pump inhibitor (PPI) and assess whether unmeasured confounding explains this association. Design Cohort study and self controlled case series. S... Read More about Community acquired pneumonia incidence before and after proton pump inhibitor prescription: population based study.

Do colorectal cancer patients diagnosed as an emergency differ from non-emergency patients in their consultation patterns and symptoms?: a longitudinal data-linkage study in England (2016)
Journal Article
Renzi, C., Lyratzopoulos, G., Card, T. R., Chu, T., Macleod, U., & Ratchet, B. (2016). Do colorectal cancer patients diagnosed as an emergency differ from non-emergency patients in their consultation patterns and symptoms?: a longitudinal data-linkage study in England. British Journal of Cancer, 115(7), https://doi.org/10.1038/bjc.2016.250

Background: More than 20% of colorectal cancers are diagnosed following an emergency presentation. We aimed to examine pre-diagnostic primary care consultations and related symptoms comparing patients diagnosed as emergencies with those diagnosed thr... Read More about Do colorectal cancer patients diagnosed as an emergency differ from non-emergency patients in their consultation patterns and symptoms?: a longitudinal data-linkage study in England.

Risk of venous thromboembolism in hospitalised cancer patients in England – A cohort study (2016)
Journal Article
Ratib, S., Walker, A. J., Card, T. R., & Grainge, M. J. (2016). Risk of venous thromboembolism in hospitalised cancer patients in England – A cohort study. Journal of Hematology and Oncology, 9, Article 60. https://doi.org/10.1186/s13045-016-0291-0

Background: Venous thromboembolism (VTE) is a well-recognised and life-threatening complication in patients with cancer. However, the precise risk of VTE in hospitalised cancer patients in England has not been previously reported. Methods: We condu... Read More about Risk of venous thromboembolism in hospitalised cancer patients in England – A cohort study.

Proton pump inhibitor prescribing patterns in the UK: a primary care database study (2016)
Journal Article
Othman, F., Card, T. R., & Crooks, C. J. (2016). Proton pump inhibitor prescribing patterns in the UK: a primary care database study. Pharmacoepidemiology and Drug Safety, 25(9), 1079-1087. https://doi.org/10.1002/pds.4043

Purpose: To determine the prevalence and pattern of proton pump inhibitor (PPI) prescription and the practices employed to reduce PPI use in the UK general population. Methods: The UK's Clinical Practice Research Database was used to identify indi... Read More about Proton pump inhibitor prescribing patterns in the UK: a primary care database study.

Risk of venous thromboembolism in people with lung cancer: a cohort study using linked UK healthcare data (2016)
Journal Article
Walker, A. J., Baldwin, D. R., Card, T. R., Powell, H. A., Hubbard, R. B., & Grainge, M. J. (in press). Risk of venous thromboembolism in people with lung cancer: a cohort study using linked UK healthcare data. British Journal of Cancer, 115(1), https://doi.org/10.1038/bjc.2016.143

Background: Venous thromboembolism is a potentially preventable cause of death in people with lung cancer. Identification of those most at risk and high risk periods may provide the opportunity for better targeted intervention. Methods: We conduc... Read More about Risk of venous thromboembolism in people with lung cancer: a cohort study using linked UK healthcare data.

Extra-gastrointestinal manifestations of inflammatory bowel disease may be less common than previously reported (2016)
Journal Article
Card, T. R., Langan, S. M., & Chu, T. P. (2016). Extra-gastrointestinal manifestations of inflammatory bowel disease may be less common than previously reported. Digestive Diseases and Sciences, 61(9), 2619-2626. https://doi.org/10.1007/s10620-016-4195-1

Extra-intestinal manifestations are well recognized in inflammatory bowel disease (IBD). To what extent the commonly recognized extra-intestinal manifestations seen in IBD patients are attributable to IBD is, however, not clear due to the limited num... Read More about Extra-gastrointestinal manifestations of inflammatory bowel disease may be less common than previously reported.

Calculating total health service utilisation and costs from routinely collected electronic health records using the example of patients with irritable bowel syndrome before and after their first gastroenterology appointment (2015)
Journal Article
Canavan, C., West, J., & Card, T. R. (in press). Calculating total health service utilisation and costs from routinely collected electronic health records using the example of patients with irritable bowel syndrome before and after their first gastroenterology appointment. PharmacoEconomics, 34(2), https://doi.org/10.1007/s40273-015-0339-y

INTRODUCTION: Health economic models are increasingly important in funding decisions but most are based on data, which may therefore not represent the general population. We sought to establish the potential of real-world data available within the Cl... Read More about Calculating total health service utilisation and costs from routinely collected electronic health records using the example of patients with irritable bowel syndrome before and after their first gastroenterology appointment.

Change in quality of life for patients with irritable bowel syndrome following referral to a gastroenterologist: a cohort study (2015)
Journal Article
Canavan, C., West, J., & Card, T. R. (2015). Change in quality of life for patients with irritable bowel syndrome following referral to a gastroenterologist: a cohort study. PLoS ONE, 10(10), Article e0139389. https://doi.org/10.1371/journal.pone.0139389

BACKGROUND: Irritable bowel syndrome (IBS), a chronic functional condition, considerably reduces quality of life (QoL) and referral to gastroenterology is common. Until now, however, the impact of seeing a gastroenterologist for IBS on patients’ QoL... Read More about Change in quality of life for patients with irritable bowel syndrome following referral to a gastroenterologist: a cohort study.

Causes of death in people with coeliac disease in England compared with the general population: a competing risk analysis (2015)
Journal Article
Abdul Sultan, A., Crooks, C. J., Card, T. R., Tata, L. J., Fleming, K. M., & West, J. (2015). Causes of death in people with coeliac disease in England compared with the general population: a competing risk analysis. Gut, 64(8), https://doi.org/10.1136/gutjnl-2014-308285

INTRODUCTION: Quantifying excess cause-specific mortality among people with coeliac disease (CD) compared with the general population accounting for competing risks will allow accurate information to be given on risk of death from specific causes.... Read More about Causes of death in people with coeliac disease in England compared with the general population: a competing risk analysis.

Direct targeting of risk factors significantly increases the detection of liver cirrhosis in primary care: a cross-sectional diagnostic study utilising transient elastography (2015)
Journal Article
Harman, D. J., Ryder, S. D., James, M. W., Jelpke, M., Ottey, D. S., Wilkes, E. A., …Guha, I. N. (2015). Direct targeting of risk factors significantly increases the detection of liver cirrhosis in primary care: a cross-sectional diagnostic study utilising transient elastography. BMJ Open, 5(4), Article e007516. https://doi.org/10.1136/bmjopen-2014-007516

OBJECTIVES: To assess the feasibility of a novel diagnostic algorithm targeting patients with risk factors for chronic liver disease in a community setting. DESIGN: Prospective cross-sectional study. SETTING: Two primary care practices (adult... Read More about Direct targeting of risk factors significantly increases the detection of liver cirrhosis in primary care: a cross-sectional diagnostic study utilising transient elastography.

Socioeconomic variation in the incidence of childhood coeliac disease in the UK (2015)
Journal Article
Zingone, F., West, J., Crooks, C. J., Fleming, K. M., Card, T. R., Ciacci,, C., & Tata, L. J. (2015). Socioeconomic variation in the incidence of childhood coeliac disease in the UK. Archives of Disease in Childhood, 100(5), https://doi.org/10.1136/archdischild-2014-307105

BACKGROUND: Serological studies indicate that evidence of coeliac disease (CD) exists in about 1% of all children, but we lack estimates of current diagnostic patterns among children and how they vary by socioeconomic group. METHODS: We identifie... Read More about Socioeconomic variation in the incidence of childhood coeliac disease in the UK.

Screening for celiac disease in the general population and in high-risk groups (2014)
Journal Article
Ludvigsson, J. F., Card, T. R., Kaukinen, K., Bai, J., Zingone, F., Sanders, D. S., & Murray, J. A. (in press). Screening for celiac disease in the general population and in high-risk groups. United European Gastroenterology Journal, 3(2), https://doi.org/10.1177/2050640614561668

BACKGROUND: Celiac disease (CD) occurs in approximately 1% of the Western population. It is a lifelong disorder that is associated with impaired quality of life (QOL) and an excessive risk of comorbidity and death. OBJECTIVES: To review the liter... Read More about Screening for celiac disease in the general population and in high-risk groups.

Psychological morbidity of celiac disease: a review of the literature (2014)
Journal Article
Zingone, F., Swift, G. L., Card, T. R., Sanders, D. S., Ludvigsson, J. F., & Bai, J. C. (2015). Psychological morbidity of celiac disease: a review of the literature. United European Gastroenterology Journal, 3(2), https://doi.org/10.1177/2050640614560786

BACKGROUND: Celiac disease has been linked to decreased quality of life and certain mood disorders. The effect of the gluten free diet on these psychological aspects of the disease is still unclear. OBJECTIVES: The objective of this article is to... Read More about Psychological morbidity of celiac disease: a review of the literature.

Are IBD patients more likely to have a prior diagnosis of irritable bowel syndrome?: report of a case-control study in the General Practice Research Database (2014)
Journal Article
Card, T. R., Siffledeen, J., & Fleming, K. M. (2014). Are IBD patients more likely to have a prior diagnosis of irritable bowel syndrome?: report of a case-control study in the General Practice Research Database. United European Gastroenterology Journal, 2(6), https://doi.org/10.1177/2050640614554217

Background: Inflammatory bowel disease (IBD) patients are sometimes first diagnosed with irritable bowel syndrome (IBS), which may be construed as a misdiagnosis. Objective: The objective of this article is to determine if this occurs more than ex... Read More about Are IBD patients more likely to have a prior diagnosis of irritable bowel syndrome?: report of a case-control study in the General Practice Research Database.

The incidence of other gastroenterological disease following diagnosis of irritable bowel syndrome in the UK: a cohort study (2014)
Journal Article
Canavan, C., Card, T. R., & West, J. (2014). The incidence of other gastroenterological disease following diagnosis of irritable bowel syndrome in the UK: a cohort study. PLoS ONE, 9(9), Article e106478. https://doi.org/10.1371/journal.pone.0106478

BACKGROUND: Guidelines recommend Irritable Bowel Syndrome (IBS) diagnosis and management in primary care with minimal investigations; however little evidence exists regarding risk of organic gastrointestinal conditions following diagnosis of IBS and... Read More about The incidence of other gastroenterological disease following diagnosis of irritable bowel syndrome in the UK: a cohort study.

Review article: the economic impact of the irritable bowel syndrome (2014)
Journal Article
Canavan, C., West, J., & Card, T. R. (in press). Review article: the economic impact of the irritable bowel syndrome. Alimentary Pharmacology and Therapeutics, 40(9), https://doi.org/10.1111/apt.12938

Background: Irritable bowel syndrome (IBS) is a chronic functional disorder of the gastrointestinal system affecting a large number of people worldwide. Whilst it has no attributable mortality, it has substantial impact on patients' quality of life (... Read More about Review article: the economic impact of the irritable bowel syndrome.