All Outputs (8)

‘Vivaldi’: an amplicon-based whole-genome sequencing method for the four seasonal human coronaviruses, 229E, NL63, OC43 and HKU1, alongside SARS-CoV-2 (2025)
Journal Article
McClure, P. C., Tsoleridis, T., Hill, J. D., Holmes, N., Chappell, J. G., Byaruhanga, T., Duncan, J., Tofan, M., Berry, L., Clark, G., L. Irving, W., Tarr, A. W., Ball, J. K., Astbury, S., & Loose, M. (2025). ‘Vivaldi’: an amplicon-based whole-genome sequencing method for the four seasonal human coronaviruses, 229E, NL63, OC43 and HKU1, alongside SARS-CoV-2. Microbial Genomics, 11, Article 001451. https://doi.org/10.1099/mgen.0.001451

Prior to the emergence of SARS-CoV-2 in 2019, alphacoronaviruses 229E and NL63 and betacoronaviruses OC43 and HKU1 were already established endemic ‘common cold’ viral infections. Despite their collective contribution towards global respiratory morbi... Read More about ‘Vivaldi’: an amplicon-based whole-genome sequencing method for the four seasonal human coronaviruses, 229E, NL63, OC43 and HKU1, alongside SARS-CoV-2.

Wisteria floribunda agglutinin enhances Zaire ebolavirus entry through interactions at specific N-linked glycosylation sites on the virus glycoprotein complex (2025)
Journal Article
Duncan, J., Pathak, M., King, B., Bamber, H., Radford, P., Dey, J., Richardson, C., Astbury, S., McClure, P., Ball, J. K., Urbanowicz, R. A., & Tarr, A. (2025). Wisteria floribunda agglutinin enhances Zaire ebolavirus entry through interactions at specific N-linked glycosylation sites on the virus glycoprotein complex. Journal of General Virology, 106(6), Article 002120. https://doi.org/10.1099/jgv.0.002120

Entry of Zaire ebolavirus (EBOV) into a host cell is a complex process requiring interactions between the viral glycoproteins (GPs) and cellular factors. These entry factors are cell-specific and can include cell surface lectins and phosphatidylserin... Read More about Wisteria floribunda agglutinin enhances Zaire ebolavirus entry through interactions at specific N-linked glycosylation sites on the virus glycoprotein complex.

Transcriptomic and proteomic characterization of cell and protein biomarkers of checkpoint inhibitor-induced liver injury (2025)
Journal Article
Ji, C., Kumpf, S., Qian, J., Federspiel, J. D., Sheehan, M., Capunitan, D., Atallah, E., Astbury, S., Arat, S., Oziolor, E., Ocana, M. F., Ramaiah, S. K., Grove, J., Aithal, G. P., & Lanz, T. A. (2025). Transcriptomic and proteomic characterization of cell and protein biomarkers of checkpoint inhibitor-induced liver injury. Cancer Immunology, Immunotherapy, 74(6), Article 190. https://doi.org/10.1007/s00262-025-04033-z

Immune checkpoint inhibitors (ICI) targeting CTLA-4 and PD-1 have shown remarkable antitumor efficacy, but can also cause immune-related adverse events, including checkpoint inhibitor-induced liver injury (ChILI). This multi-omic study aimed to inves... Read More about Transcriptomic and proteomic characterization of cell and protein biomarkers of checkpoint inhibitor-induced liver injury.

Role of hepatocellular senescence in the development of hepatocellular carcinoma and the potential for therapeutic manipulation (2025)
Journal Article
Wijayasiri, P., Astbury, S., Needham, G., Kaye, P., Bhat, M., Piccinini, A. M., & Aravinthan, A. D. (2025). Role of hepatocellular senescence in the development of hepatocellular carcinoma and the potential for therapeutic manipulation. Human Cell, 38(3), Article 70. https://doi.org/10.1007/s13577-025-01201-2

Accumulation of senescent hepatocytes is universal in chronic liver disease (CLD). This study investigates an association between hepatocyte senescence and hepatocellular carcinoma (HCC) and explores the therapeutic role of sirolimus. Background live... Read More about Role of hepatocellular senescence in the development of hepatocellular carcinoma and the potential for therapeutic manipulation.

Vivaldi: An amplicon-based whole genome sequencing method for the four seasonal human coronaviruses 229E, NL63, OC43 & HKU1, alongside SARS-CoV-2 (2024)
Preprint / Working Paper
McClure, C. P., Tsoleridis, T., Holmes, N., Chappell, J. G., Byaruhanga, T., Duncan, J., Tofan, M., Khater, A., Berry, L., Clark, G., Irving, W. L., Tarr, A. W., Ball, J. K., Astbury, S., & Loose, M. Vivaldi: An amplicon-based whole genome sequencing method for the four seasonal human coronaviruses 229E, NL63, OC43 & HKU1, alongside SARS-CoV-2

Prior to the emergence of SARS-CoV-2 in 2019, Alphacoronaviruses 229E and NL63 and Betacoronaviruses OC43 and HKU1 were already established endemic ‘common cold’ viral infections. Despite their collective contribution towards global respiratory morbi... Read More about Vivaldi: An amplicon-based whole genome sequencing method for the four seasonal human coronaviruses 229E, NL63, OC43 & HKU1, alongside SARS-CoV-2.

Next-generation sequencing of pancreatic cyst wall specimens obtained using micro-forceps for improving diagnostic accuracy (2023)
Journal Article
Astbury, S., Baskar, A., Grove, J. I., Kaye, P., Aravinthan, A. D., James, M., Clarke, C., Aithal, G. P., & Venkatachalapathy, S. V. (2023). Next-generation sequencing of pancreatic cyst wall specimens obtained using micro-forceps for improving diagnostic accuracy. Endoscopy International Open, 11(10), E983-E991. https://doi.org/10.1055/a-2163-8805

Background and study aims: Pancreatic cysts are common incidental findings, with an estimated prevalence of 13-15% in imaging done for other reasons. Diagnosis often relies on collection of cyst fluid, but tissue sampling using micro-forceps may allo... Read More about Next-generation sequencing of pancreatic cyst wall specimens obtained using micro-forceps for improving diagnostic accuracy.

Next-generation sequencing of pancreatic cyst wall specimens obtained using Moray micro-forceps for improving diagnostic accuracy (2023)
Preprint / Working Paper
Astbury, S., Baskar, A., Grove, J. I., Kaye, P., Aravinthan, A. D., James, M. W., Clarke, C., Aithal, G. P., & Venkatachalapathy, S. V. Next-generation sequencing of pancreatic cyst wall specimens obtained using Moray micro-forceps for improving diagnostic accuracy

Background and study aims Pancreatic cysts are common incidental findings, with an estimated prevalence of 13-15% in imaging done for other reasons. It is difficult to identify cysts with malignant potential. Diagnosis often relies on collection of c... Read More about Next-generation sequencing of pancreatic cyst wall specimens obtained using Moray micro-forceps for improving diagnostic accuracy.

Reproducible microbiome composition signatures of anxiety and depressive symptoms (2023)
Journal Article
Kouraki, A., Kelly, A., Vijay, A., Gohir, S., Astbury, S., Georgopoulos, V., Millar, B., Walsh, D. A., Ferguson, E., Menni, C., & Valdes, A. M. (2023). Reproducible microbiome composition signatures of anxiety and depressive symptoms. Computational and Structural Biotechnology Journal, 21, 5326-5336. https://doi.org/10.1016/j.csbj.2023.10.035

The gut microbiome is a significant contributor to mental health, with growing evidence linking its composition to anxiety and depressive disorders. Gut microbiome composition is associated with signs of anxiety and depression both in clinically diag... Read More about Reproducible microbiome composition signatures of anxiety and depressive symptoms.