All Outputs (2)

Key phosphorylation sites for robust β-arrestin2 binding at the MOR revisited (2024)
Journal Article
Underwood, O., Fritzwanker, S., Glenn, J., Blum, N. K., Batista-Gondin, A., Drube, J., Hoffmann, C., Briddon, S. J., Schulz, S., & Canals, M. (2024). Key phosphorylation sites for robust β-arrestin2 binding at the MOR revisited. Communications Biology, 7, Article 933. https://doi.org/10.1038/s42003-024-06571-1

Desensitisation of the mu-opioid receptor (MOR) is proposed to underlie the initiation of opioid analgesic tolerance and previous work has shown that agonist-induced phosphorylation of the MOR C-tail contributes to this desensitisation. Moreover, pho... Read More about Key phosphorylation sites for robust β-arrestin2 binding at the MOR revisited.

Ligand-Directed Labeling of the Adenosine A1 Receptor in Living Cells (2024)
Journal Article
Comeo, E., Goulding, J., Lin, C.-Y., Groenen, M., Woolard, J., Kindon, N. D., Harwood, C. R., Platt, S., Briddon, S. J., Kilpatrick, L. E., Scammells, P. J., Hill, S. J., & Kellam, B. (2024). Ligand-Directed Labeling of the Adenosine A1 Receptor in Living Cells. Journal of Medicinal Chemistry, 67(14), 12099–12117. https://doi.org/10.1021/acs.jmedchem.4c00835

The study of protein function and dynamics in their native cellular environment is essential for progressing fundamental science. To overcome the requirement of genetic modification of the protein or the limitations of dissociable fluorescent ligands... Read More about Ligand-Directed Labeling of the Adenosine A1 Receptor in Living Cells.