All Outputs (6)

New perspectives on iron uptake in eukaryotes (2018)
Journal Article
Sherman, H. G., Jovanovic, C., Stolnik, S., Baronian, K., Downard, A. J., & Rawson, F. J. (2018). New perspectives on iron uptake in eukaryotes. Frontiers in Molecular Biosciences, 5(NOV), Article 97. https://doi.org/10.3389/fmolb.2018.00097

All eukaryotic organisms require iron to function. Malfunctions within iron homeostasis have a range of physiological consequences, and can lead to the development of pathological conditions that can result in an excess of non-transferrin bound iron... Read More about New perspectives on iron uptake in eukaryotes.

Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printing (2018)
Journal Article
Lovato, T., Taresco, V., Alazzo, A., Sansone, C., Stolnik, S., Alexander, C., & Conte, C. (2018). Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printing. Journal of Materials Chemistry B, 6(41), 6550-6558. https://doi.org/10.1039/C8TB01215F

Here we describe a rapid inkjet formulation method for screening newly-synthesised cationic materials for siRNA delivery into cancer cells. Reduction responsive oligo-β-aminoesters were prepared and evaluated for their ability to condense siRNA into... Read More about Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printing.

Structural variations in hyperbranched polymers prepared via thermal polycondensation of lysine and histidine and their effects on DNA delivery (2018)
Journal Article
Alazzo, A., Lovato, T., Collins, H. M., Taresco, V., Stolnik, S., Soliman, M. E., …Alexander, C. (2018). Structural variations in hyperbranched polymers prepared via thermal polycondensation of lysine and histidine and their effects on DNA delivery. Journal of Interdisciplinary Nanomedicine, 3(2), https://doi.org/10.1002/jin2.36

The successful clinical translation of non-viral gene delivery systems has yet to be achieved due to the biological and technical obstacles to preparing a safe, potent and cost-effective vector. Hyper-branched polymers have emerged as promising candi... Read More about Structural variations in hyperbranched polymers prepared via thermal polycondensation of lysine and histidine and their effects on DNA delivery.

Water-soluble substituted chitosan derivatives as technology platform for inhalation delivery of siRNA (2018)
Journal Article
Capel, V., Vllasaliu, D., Watts, P., Clarke, P. A., Luxton, D., Grabowska, A. M., …Stolnik, S. (in press). Water-soluble substituted chitosan derivatives as technology platform for inhalation delivery of siRNA. Drug Delivery, 25(1), https://doi.org/10.1080/10717544.2018.1440668

Despite research efforts full potential of siRNA-based therapeutics has not yet been fully realized due to a need for suitable, effective delivery formulations. Here, we examine a potential of a new class of water-soluble chitosans as siRNA platform... Read More about Water-soluble substituted chitosan derivatives as technology platform for inhalation delivery of siRNA.

Pathways of cellular internalisation of liposomes delivered siRNA and effects on siRNA engagement with target mRNA and silencing in cancer cells (2018)
Journal Article
Alshehri, A. A., Grabowska, A. M., & Stolnik, S. (in press). Pathways of cellular internalisation of liposomes delivered siRNA and effects on siRNA engagement with target mRNA and silencing in cancer cells. Scientific Reports, 8(1), https://doi.org/10.1038/s41598-018-22166-3

Design of an efficient delivery system is a generally recognised bottleneck in translation of siRNA technology into clinic. Despite research efforts, cellular processes that determine efficiency of siRNA silencing achieved by different delivery formu... Read More about Pathways of cellular internalisation of liposomes delivered siRNA and effects on siRNA engagement with target mRNA and silencing in cancer cells.

An electrochemical system for the study of trans-plasma membrane electron transport in whole eukaryotic cells (2018)
Journal Article
Sherman, H. G., Jovanovic, C., Stolnik, S., & Rawson, F. J. (in press). An electrochemical system for the study of trans-plasma membrane electron transport in whole eukaryotic cells. Analytical Chemistry, 90(4), https://doi.org/10.1021/acs.analchem.7b04853

The development of new assays to study trans-plasma membrane electron transport (tPMET) in eukaryotic systems is paramount for a number reasons, which include the further understanding of the underlying biology which can then potentially be applied t... Read More about An electrochemical system for the study of trans-plasma membrane electron transport in whole eukaryotic cells.