Research Repository

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Extreme osmotolerance and halotolerance in food-relevant yeasts and the role of glycerol-dependent cell individuality (2019)
Journal Article
Stratford, M., Steels, H., Novodvorska, M., Archer, D. B., & Avery, S. V. (2019). Extreme osmotolerance and halotolerance in food-relevant yeasts and the role of glycerol-dependent cell individuality. Frontiers in Microbiology, 9, 1-14. doi:10.3389/fmicb.2018.03238

Osmotolerance and halotolerance are used to describe resistance to sugars and salt, respectively. Here, a comprehensive screen of more than 600 different yeast isolates revealed that osmosensitive species were equally affected by NaCl and glucose. Ho... Read More

Novel combinations of agents targeting translation that synergistically inhibit fungal pathogens (2018)
Journal Article
Vallières, C., Raulo, R., Dickinson, M., & Avery, S. V. (2018). Novel combinations of agents targeting translation that synergistically inhibit fungal pathogens. Frontiers in Microbiology, 9, doi:10.3389/fmicb.2018.02355 . ISSN 1664-302X

A range of fungicides or antifungals are currently deployed to control fungi in agriculture or medicine, but resistance to current agents is growing so new approaches and molecular targets are urgently needed. Recently, different aminoglycoside antib... Read More

Mitochondrial ferredoxin determines vulnerability of cells to copper excess (2017)
Journal Article
Vallières, C., Holland, S. L., & Avery, S. V. (2017). Mitochondrial ferredoxin determines vulnerability of cells to copper excess. Cell Chemical Biology, 24, doi:10.1016/j.chembiol.2017.08.005. ISSN 2451-9456

The essential micronutrient copper is tightly regulated in organisms, as environmental exposure or homeostasis defects can cause toxicity and neurodegenerative disease. The principal target(s) of copper toxicity have not been pinpointed, but one key... Read More

The candidate antimalarial drug MMV665909 causes oxygen-dependent mRNA mistranslation and synergises with quinoline-derived antimalarials (2017)
Journal Article
Vallieres, C., & Avery, S. V. (2017). The candidate antimalarial drug MMV665909 causes oxygen-dependent mRNA mistranslation and synergises with quinoline-derived antimalarials. Antimicrobial Agents and Chemotherapy, 61(9), doi:10.1128/AAC.00459-17. ISSN 0066-4804

To cope with growing resistance to current antimalarials, new drugs with novel modes of action are urgently needed. Molecules targeting protein synthesis appear to be promising candidates. We identified a compound (MMV665909) from the MMV Malaria Box... Read More

The next generation fungal diversity researcher (2017)
Journal Article
Grube, M., Gaya, E., Kauserud, H., Smith, A. M., Avery, S. V., Fernstad, S. J., …Bendiksby, M. (2017). The next generation fungal diversity researcher. Fungal Biology Reviews, 31(3), doi:10.1016/j.fbr.2017.02.001. ISSN 1749-4613

Fungi are more important to our lives than is assumed by the general public. They can comprise both devastating pathogens and plant-associated mutualists in nature, and several species have also become important workhorses of biotechnology. Fungal di... Read More

Metal-based combinations that target protein synthesis by fungi (2017)
Journal Article
Vallières, C., & Avery, S. V. (2017). Metal-based combinations that target protein synthesis by fungi. Advances in Microbial Physiology, 70, doi:10.1016/bs.ampbs.2017.01.001. ISSN 2162-5468

A wide range of fungicides (or antifungals) are used in agriculture and medicine, with activities against a spectrum of fungal pathogens. Unfortunately, the evolution of fungicide resistance has become a major issue. Therefore, there is an urgent nee... Read More

Open source drug discovery with the Malaria Box Compound collection for neglected diseases and beyond (2016)
Journal Article
Phillips, M. A., Van Voorhis, W. C., Adams, J. H., Adelfio, R., Ahyong, V., Akabas, M. H., …Willis, P. A. (2016). Open source drug discovery with the Malaria Box Compound collection for neglected diseases and beyond. PLoS Pathogens, 12(7), doi:10.1371/journal.ppat.1005763. ISSN 1553-7366

A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is still larg... Read More

The antimalarial drug primaquine targets Fe–S cluster proteins and yeast respiratory growth (2015)
Journal Article
Lalève, A., Vallieres, C., Golinelli-Cohen, M., Bouton, C., Song, Z., Pawlik, G., …Meunier, B. (2016). The antimalarial drug primaquine targets Fe–S cluster proteins and yeast respiratory growth. Redox Biology, 7, doi:10.1016/j.redox.2015.10.008. ISSN 2213-2317

Malaria is a major health burden in tropical and subtropical countries. The antimalarial drug primaquine is extremely useful for killing the transmissible gametocyte forms of Plasmodium falciparum and the hepatic quiescent forms of P. vivax. Yet its... Read More

The antimalarial drug quinine interferes with serotonin biosynthesis and action (2014)
Journal Article
Islahudin, F., Tindall, S. M., Mellor, I. R., Swift, K., Christensen, H. E., Fone, K. C., …Avery, S. V. (2014). The antimalarial drug quinine interferes with serotonin biosynthesis and action. Scientific Reports, 4(3618), doi:10.1038/srep03618. ISSN 2045-2322

The major antimalarial drug quinine perturbs uptake of the essential amino acid tryptophan, and patients with low plasma tryptophan are predisposed to adverse quinine reactions; symptoms of which are similar to indications of tryptophan depletion. As... Read More

Phenotypic heterogeneity is a selected trait in natural yeast populations subject to environmental stress (2013)
Journal Article
yeast populations subject to environmental stress. Environmental Microbiology, doi:10.1111/1462-2920.12243. ISSN 1462-2912

Populations of genetically uniform microorganisms exhibit phenotypic heterogeneity, where individual cells have varying phenotypes. Such phenotypes include fitness-determining traits. Phenotypic heterogeneity has been linked to increased populati... Read More

Cell wall perturbation sensitizes fungi to the antimalarial drug chloroquine (2013)
Journal Article
Islahudin, F., Khozoie, C., Bates, S., Ting, K., Pleass, R. J., & Avery, S. V. (2013). Cell wall perturbation sensitizes fungi to the antimalarial drug chloroquine. Antimicrobial Agents and Chemotherapy, 57(8), doi:10.1128/AAC.00478-13. ISSN 0066-4804

Chloroquine (CQ) has been a mainstay of antimalarial drug treatment for several decades. Additional therapeutic actions of CQ have been described, including some reports of fungal inhibition. Here we investigated the action of CQ in fungi, including... Read More

The essential iron-sulfur protein Rli1 is an important target accounting for inhibition of cell growth by reactive oxygen species (2012)
Journal Article
Alhebshi, A., Sideri, T. C., Holland, S. L., & Avery, S. V. (2012). The essential iron-sulfur protein Rli1 is an important target accounting for inhibition of cell growth by reactive oxygen species. Molecular Biology of the Cell, 23(18), doi:10.1091/mbc.E12-05-0413. ISSN 1059-1524

Oxidative stress mediated by reactive oxygen species (ROS) is linked to degenerative conditions in humans and damage to an array of cellular components. However, it is unclear which molecular target(s) may be the primary “Achilles’ heel” of organisms... Read More