All Outputs (2)

Developing IBD Outcome Effect Size Thresholds to Inform Research, Guidelines, and Clinical Decisions (2025)
Journal Article
Gordon, M., Shaban, N., Sinopoulou, V., Vuyyuru, S., Radford, S., Magro, F., Armuzzi, A., Peyrin-Biroulet, L., Jairath, V., & Moran, G. (2025). Developing IBD Outcome Effect Size Thresholds to Inform Research, Guidelines, and Clinical Decisions. Inflammatory Bowel Diseases, https://doi.org/10.1093/ibd/izaf085

Background
When designing clinical trials, interpreting trial outcomes for guideline development or sharing decisions with patients in clinical practice, the clinical outcomes used and the implicit choices on what constitutes a clinically significan... Read More about Developing IBD Outcome Effect Size Thresholds to Inform Research, Guidelines, and Clinical Decisions.

Developing an adaptive platform trial for evaluation of medical treatments for Crohn’s disease (2025)
Journal Article
Noor, N. M., Radford, S. J., Choodari-Oskooei, B., Gordon, M., Hart, A. L., Hepburn, T., Juszczak, E., Lindsay, J. O., Kennedy, N. A., Parmar, M. K. B., Jairath, V., & Moran, G. W. (2025). Developing an adaptive platform trial for evaluation of medical treatments for Crohn’s disease. Nature Reviews Gastroenterology and Hepatology, 22, 364-366. https://doi.org/10.1038/s41575-025-01052-0

There is emerging interest in adaptive platform trials for inflammatory bowel disease. In this Comment, we present the results of a workshop that was convened to consider the opportunities and challenges of developing a platform trial in Crohn’s dise... Read More about Developing an adaptive platform trial for evaluation of medical treatments for Crohn’s disease.