All Outputs (2)

Structure of the human Ccr4-Not nuclease module using X-ray crystallography and electron paramagnetic resonance spectroscopy distance measurements (2021)
Journal Article
Zhang, Q., Pavanello, L., Potapov, A., Bartlam, M., & Winkler, G. S. (2022). Structure of the human Ccr4-Not nuclease module using X-ray crystallography and electron paramagnetic resonance spectroscopy distance measurements. Protein Science, 31(3), 758-764. https://doi.org/10.1002/pro.4262

Regulated degradation of mature, cytoplasmic mRNA is a key step in eukaryotic gene regulation. This process is typically initiated by the recruitment of deadenylase enzymes by cis-acting elements in the 3' untranslated region resulting in the shorten... Read More about Structure of the human Ccr4-Not nuclease module using X-ray crystallography and electron paramagnetic resonance spectroscopy distance measurements.

Design of artificial metalloenzymes for the reduction of nicotinamide cofactors (2021)
Journal Article
Basle, M., Padley, H. A., Martins, F. L., Winkler, G. S., Jäger, C. M., & Pordea, A. (2021). Design of artificial metalloenzymes for the reduction of nicotinamide cofactors. Journal of Inorganic Biochemistry, 220, Article 111446. https://doi.org/10.1016/j.jinorgbio.2021.111446

Artificial metalloenzymes result from the insertion of a catalytically active metal complex into a biological scaffold, generally a protein devoid of other catalytic functionalities. As such, their design requires efforts to engineer substrate bindin... Read More about Design of artificial metalloenzymes for the reduction of nicotinamide cofactors.