All Outputs (5)

Unravelling transcriptomic complexity in breast cancer through modulation of DARPP-32 expression and signalling pathways (2023)
Journal Article
Saidy, B., Vasan, R., Durant, R., Greener, M.-R., Immanuel, A., Green, A. R., Rakha, E., Ellis, I., Ball, G., Martin, S. G., & Storr, S. J. (2023). Unravelling transcriptomic complexity in breast cancer through modulation of DARPP-32 expression and signalling pathways. Scientific Reports, 13(1), Article 21163. https://doi.org/10.1038/s41598-023-48198-y

DARPP-32 is a key regulator of protein-phosphatase-1 (PP-1) and protein kinase A (PKA), with its function dependent upon its phosphorylation state. We previously identified DKK1 and GRB7 as genes with linked expression using Artificial Neural Network... Read More about Unravelling transcriptomic complexity in breast cancer through modulation of DARPP-32 expression and signalling pathways.

High BMP7 expression is associated with poor prognosis in ovarian cancer (2023)
Journal Article
Vasan, R., Yadav, J., Aiyappa‐Maudsley, R., Deen, S., Storr, S. J., & Martin, S. G. (2023). High BMP7 expression is associated with poor prognosis in ovarian cancer. Journal of Cellular and Molecular Medicine, 27(21), 3378-3387. https://doi.org/10.1111/jcmm.17951

Bone Morphogenetic Protein 7 (BMP7) is an extracellular signalling protein that belongs to the transforming growth factor‐β (TGF‐ β) superfamily. Previous transcriptomic data suggested that BMP7 expression may be disrupted in ovarian carcinoma and ma... Read More about High BMP7 expression is associated with poor prognosis in ovarian cancer.

HER2 inhibition increases non-muscle myosin IIA to promote tumorigenesis in HER2+ breast cancers (2023)
Journal Article
Alanazi, S. M., Feroz, W., Mishra, R., Kilroy, M. K., Patel, H., Yuan, L., Storr, S. J., & Garrett, J. T. (2023). HER2 inhibition increases non-muscle myosin IIA to promote tumorigenesis in HER2+ breast cancers. PLoS ONE, 18(5), Article e0285251. https://doi.org/10.1371/journal.pone.0285251

HER2 is over-expressed in around 15% to 20% of breast cancers. HER3 plays a critical role in HER2 mediated tumorigenesis. Increased HER3 transcription and protein levels occur upon inhibition of HER2. We aimed to identify proteins that bound to HER3... Read More about HER2 inhibition increases non-muscle myosin IIA to promote tumorigenesis in HER2+ breast cancers.

p53 and ovarian carcinoma survival: an Ovarian Tumor Tissue Analysis consortium study (2023)
Journal Article
Köbel, M., Kang, E., Weir, A., Rambau, P. F., Lee, C., Nelson, G. S., Ghatage, P., Meagher, N. S., Riggan, M. J., Alsop, J., Anglesio, M. S., Beckmann, M. W., Bisinotto, C., Boisen, M., Boros, J., Brand, A. H., Brooks‐Wilson, A., Carney, M. E., Coulson, P., Courtney‐Brooks, M., …Brenton, J. D. (2023). p53 and ovarian carcinoma survival: an Ovarian Tumor Tissue Analysis consortium study. Journal of Pathology: Clinical Research, 9(3), 208-222. https://doi.org/10.1002/cjp2.311

Our objective was to test whether p53 expression status is associated with survival for women diagnosed with the most common ovarian carcinoma histotypes (high‐grade serous carcinoma [HGSC], endometrioid carcinoma [EC], and clear cell carcinoma [CCC]... Read More about p53 and ovarian carcinoma survival: an Ovarian Tumor Tissue Analysis consortium study.

A retrospective analysis of ezrin protein and mRNA expression in breast cancer: Ezrin expression is associated with patient survival and survival of patients with receptor-positive disease (2023)
Journal Article
Storr, S. J., Hoskin, V., Aiyappa‐Maudsley, R., Ghaffari, A., Varma, S., Green, A., Rakha, E., Ellis, I. O., Greer, P. A., & Martin, S. G. (2023). A retrospective analysis of ezrin protein and mRNA expression in breast cancer: Ezrin expression is associated with patient survival and survival of patients with receptor-positive disease. Cancer Medicine, 12(9), 10908-10916. https://doi.org/10.1002/cam4.5802

Introduction: The cytoskeletal protein ezrin is upregulated in many cancer types and is strongly associated with poor patient outcome. While the clinical and prognostic value of ezrin has been previously evaluated in breast cancer, most studies to da... Read More about A retrospective analysis of ezrin protein and mRNA expression in breast cancer: Ezrin expression is associated with patient survival and survival of patients with receptor-positive disease.