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All Outputs (48)

Antiangiogenic therapy and mechanisms of tumor resistance in malignant glioma (2010)
Journal Article
Rahman, R., Smith, S., Rahman, C., & Grundy, R. (2010). Antiangiogenic therapy and mechanisms of tumor resistance in malignant glioma. Journal of Oncology, 2010, 1-16. https://doi.org/10.1155/2010/251231

Despite advances in surgery, radiation therapy, and chemotherapeutics, patients with malignant glioma have a dismal prognosis. The formations of aberrant tumour vasculature and glioma cell invasion are major obstacles for effective treatment. Angioge... Read More about Antiangiogenic therapy and mechanisms of tumor resistance in malignant glioma.

Pediatric brain tumor cancer stem cells: cell cycle dynamics, DNA repair, and etoposide extrusion (2010)
Journal Article
Hussein, D., Punjaruk, W., Storer, L. C. D., Shaw, L., Othman, R. T., Peet, A., …Coyle, B. (2011). Pediatric brain tumor cancer stem cells: cell cycle dynamics, DNA repair, and etoposide extrusion. Neuro-Oncology, 13(1), 70-83. https://doi.org/10.1093/neuonc/noq144

Reliable model systems are needed to elucidate the role cancer stem cells (CSCs) play in pediatric brain tumor drug resistance. The majority of studies to date have focused on clinically distinct adult tumors and restricted tumor types. Here, the CSC... Read More about Pediatric brain tumor cancer stem cells: cell cycle dynamics, DNA repair, and etoposide extrusion.

Histone Deacetylase Inhibition Attenuates Cell Growth with Associated Telomerase Inhibition in High-Grade Childhood Brain Tumor Cells (2010)
Journal Article
Rahman, R., Osteso-Ibanez, T., Hirst, R. A., Levesley, J., Kilday, J., Quinn, S., …Grundy, R. G. (2010). Histone Deacetylase Inhibition Attenuates Cell Growth with Associated Telomerase Inhibition in High-Grade Childhood Brain Tumor Cells. Molecular Cancer Therapeutics, 9(9), 2568-2581. https://doi.org/10.1158/1535-7163.mct-10-0272

Aberrant epigenetic regulation of gene expression contributes to tumor initiation and progression. Studies from a plethora of hematologic and solid tumors support the use of histone deacetylase inhibitors (HDACi) as potent anticancer agents. However,... Read More about Histone Deacetylase Inhibition Attenuates Cell Growth with Associated Telomerase Inhibition in High-Grade Childhood Brain Tumor Cells.

Pediatric Ependymoma: Biological Perspectives (2009)
Journal Article
Kilday, J., Rahman, R., Dyer, S., Ridley, L., Lowe, J., Coyle, B., & Grundy, R. (2009). Pediatric Ependymoma: Biological Perspectives. Molecular Cancer Research, 7(6), 765-786. https://doi.org/10.1158/1541-7786.mcr-08-0584

Pediatric ependymomas are enigmatic tumors that continue to present a clinical management challenge despite advances in neurosurgery, neuroimaging techniques, and radiation therapy. Difficulty in predicting tumor behavior from clinical and histologic... Read More about Pediatric Ependymoma: Biological Perspectives.

Cellular immortality in brain tumours: an integration of the cancer stem cell paradigm (2009)
Journal Article
Rahman, R., Heath, R., & Grundy, R. (2009). Cellular immortality in brain tumours: an integration of the cancer stem cell paradigm. BBA - Molecular Basis of Disease, 1792(4), 280-288. https://doi.org/10.1016/j.bbadis.2009.01.011

Brain tumours are a diverse group of neoplasms that continue to present a formidable challenge in our attempt to achieve curable intervention. Our conceptual framework of human brain cancer has been redrawn in the current decade. There is a gathering... Read More about Cellular immortality in brain tumours: an integration of the cancer stem cell paradigm.

Telomeric 3′-overhang length is associated with the size of telomeres (2008)
Journal Article
Rahman, R., Forsyth, N. R., & Cui, W. (2008). Telomeric 3′-overhang length is associated with the size of telomeres. Experimental Gerontology, 43(4), 258-265. https://doi.org/10.1016/j.exger.2008.01.005

Telomeres are specialized DNA/protein complexes that cap eukaryotic chromosome ends as T-loop structures and maintain genomic integrity. Vertebrate telomeric DNA consists of tandem double-strand repeats which terminate in a 3 0 single-strand G-rich o... Read More about Telomeric 3′-overhang length is associated with the size of telomeres.

Telomerase with mutated catalytic motifs has dominant negative effects on telomerase activity and inhibits cell growth (2006)
Journal Article
Rahman, R., Mo, L., & Cui, W. (2006). Telomerase with mutated catalytic motifs has dominant negative effects on telomerase activity and inhibits cell growth. Biochemical and Biophysical Research Communications, 350(3), 796-802. https://doi.org/10.1016/j.bbrc.2006.09.125

Telomerase catalytic subunit (TERT) seems a key factor controlling telomerase activity, telomere length, and cell growth. To further address this issue, we forced expression of a catalytically inactive mutant human TERT (hTERT) in hTERT-immortalised... Read More about Telomerase with mutated catalytic motifs has dominant negative effects on telomerase activity and inhibits cell growth.