All Outputs (3)

Wnt/GSK-3β mediates posttranslational modifications of FLYWCH1 to regulate intestinal epithelial function and tumorigenesis in the colon (2024)
Journal Article
Almozyan, S., Babaei-Jadidi, R., Aljohani, A., Youssefi, S., Dalleywater, W., Kadam, P., Spencer-Dene, B., Rakha, E., Ilyas, M., & Shams Nateri, A. (2025). Wnt/GSK-3β mediates posttranslational modifications of FLYWCH1 to regulate intestinal epithelial function and tumorigenesis in the colon. Cancer Communications, 45(1), 9-14. https://doi.org/10.1002/cac2.12625

Embryonic NANOG activity defines colorectal cancer stem cells and modulates through AP1- and TCF-dependent mechanisms (2012)
Journal Article
Ibrahim, E. E., Babaei-Jadidi, R., Saadeddin, A., Spencer-Dene, B., Hossaini, S., Abuzinadah, M., Li, N., Fadhil, W., Ilyas, M., Bonnet, D., & Nateri, A. S. (2012). Embryonic NANOG activity defines colorectal cancer stem cells and modulates through AP1- and TCF-dependent mechanisms. STEM CELLS, 30(10), 2076-2087. https://doi.org/10.1002/stem.1182

Embryonic NANOG (NANOG1) is considered as an important regulator of pluripotency while NANOGP8 (NANOG-pseudogene) plays a role in tumorigenesis. Herein, we show NANOG is expressed from both NANOG1 and NANOGP8 in human colorectal cancers (CRC). Enforc... Read More about Embryonic NANOG activity defines colorectal cancer stem cells and modulates through AP1- and TCF-dependent mechanisms.

FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation (2011)
Journal Article
Babaei-Jadidi, R., Li, N., Saadeddin, A., Spencer-Dene, B., Jandke, A., Muhammad, B., Ibrahim, E. S. E., Muraleedharan, R., Abuzinadah, M., Davis, H., Lewis, A., Watson, S., Behrens, A., Tomlinson, I., & Nateri, A. S. (2011). FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation. Journal of Experimental Medicine, 208(2), 295-312. https://doi.org/10.1084/jem.20100830

The Fbxw7 (F-box/WD repeat-containing protein 7; also called CDC4, Sel10, Ago, and Fbw7) component of the SCF (Skp1/Cullin/F-box protein) E3 ubiquitin ligase complex acts as a tumor suppressor in several tissues and targets multiple transcriptional a... Read More about FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation.