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Secondary care specialist visits made by children and young people prescribed antidepressants in primary care: A descriptive study using the QResearch database (2020)
Journal Article
Jack, R. H., Joseph, R. M., Coupland, C., Butler, D., Hollis, C., Morriss, R., …Hippisley-Cox, J. (2020). Secondary care specialist visits made by children and young people prescribed antidepressants in primary care: A descriptive study using the QResearch database. BMC Medicine, 18(1), Article 93. https://doi.org/10.1186/s12916-020-01560-7

© 2020 The Author(s). Background: Antidepressants may be used to manage a number of conditions in children and young people including depression, anxiety, and obsessive-compulsive disorder. UK guidelines for the treatment of depression in children an... Read More about Secondary care specialist visits made by children and young people prescribed antidepressants in primary care: A descriptive study using the QResearch database.

Impact of smoking status on the efficacy of inhaled corticosteroids in chronic obstructive pulmonary disease: a systematic review (2020)
Journal Article
Sonnex, K., Alleemudder, H., & Knaggs, R. (2020). Impact of smoking status on the efficacy of inhaled corticosteroids in chronic obstructive pulmonary disease: a systematic review. BMJ Open, 10(4), Article e037509. https://doi.org/10.1136/bmjopen-2020-037509

Objectives: Inhaled corticosteroids (ICS) reduce exacerbation rates and the decline in lung function in people with chronic obstructive pulmonary disease (COPD). There is evidence that smoking causes ‘steroid resistance’ and thus reduces the effect o... Read More about Impact of smoking status on the efficacy of inhaled corticosteroids in chronic obstructive pulmonary disease: a systematic review.

Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets (2019)
Journal Article
Jack, R. H., Hollis, C., Coupland, C., Morriss, R., Knaggs, R. D., Cipriani, A., …Hippisley-Cox, J. (2019). Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets. Evidence-Based Mental Health, 22(3), 129-133. https://doi.org/10.1136/ebmental-2019-300097

Introduction Increasing numbers of children and young people (CYP) are receiving prescriptions for antidepressants. This is the protocol of a study aiming to describe the trends and variation in antidepressant prescriptions in CYP in England, and t... Read More about Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets.

Prescription opioids: regional variation and socioeconomic status: evidence from primary care in England (2019)
Journal Article
Chen, T.-C., Chen, L.-C., Kerry, M., & Knaggs, R. D. (2019). Prescription opioids: regional variation and socioeconomic status: evidence from primary care in England. International Journal of Drug Policy, 64, 87-94. https://doi.org/10.1016/j.drugpo.2018.10.013

Background: This study aimed to quantify dispensed opioid prescriptions among primary care practices throughout England and investigate its association with socioeconomic status (SES). Methods: This cross-sectional study used publicly available data... Read More about Prescription opioids: regional variation and socioeconomic status: evidence from primary care in England.

Interventions for the reduction of prescribed opioid use in chronic non-cancer pain (2017)
Journal Article
Eccleston, C., Fisher, E., Thomas, K. H., Hearn, L., Derry, S., Stannard, C., …Moore, R. A. (in press). Interventions for the reduction of prescribed opioid use in chronic non-cancer pain. Cochrane Database of Systematic Reviews, 11, Article CD010323. https://doi.org/10.1002/14651858.CD010323.pub3

Background This is the first update of the original Cochrane Review published in 2013. The conclusions of this review have not changed from the 2013 publication. People with chronic non-cancer pain who are prescribed and are taking opioids can hav... Read More about Interventions for the reduction of prescribed opioid use in chronic non-cancer pain.

A 15-year overview of increasing tramadol utilisation and associated mortality and the impact of tramadol classification in the United Kingdom (2017)
Journal Article
Chen, T.-C., Chen, L.-C., & Knaggs, R. D. (2018). A 15-year overview of increasing tramadol utilisation and associated mortality and the impact of tramadol classification in the United Kingdom. Pharmacoepidemiology and Drug Safety, 27(5), 487-494. https://doi.org/10.1002/pds.4320

Purpose This study aimed to develop hypotheses to explain the increasing tramadol utilisation, evaluate the impact of tramadol classification, and explore the trend between tramadol utilisation and related deaths in the United Kingdom. Methods... Read More about A 15-year overview of increasing tramadol utilisation and associated mortality and the impact of tramadol classification in the United Kingdom.

Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome (2017)
Journal Article
Reckziegel, D., Bailey, H., Cottam, W. J., Tench, C. R., Mahajan, R. P., Walsh, D. A., …Auer, D. P. (in press). Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome. BMJ Open, 7(6), Article e014013. https://doi.org/10.1136/bmjopen-2016-014013

Introduction: Osteoarthritis (OA) pain is a major cause of long-term disability and chronic pain in the adult population. One in five patients does not receive satisfactory pain relief, which reflects the complexity of chronic pain and the current la... Read More about Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome.

Rapid acting fentanyl formulations in breakthrough pain in cancer: drug selection by means of the System of Objectified Judgement Analysis (2017)
Journal Article
Janknegt, R., van den Beuken, M., Schiere, S., Überall, M., Knaggs, R., Hanley, J., & Thronaes, M. (in press). Rapid acting fentanyl formulations in breakthrough pain in cancer: drug selection by means of the System of Objectified Judgement Analysis. European Journal of Hospital Pharmacy, 25(3), https://doi.org/10.1136/ejhpharm-2016-001127

Drug selection of rapid acting fentanyl formulations in the treatment of breakthrough pain in patients with cancer is performed by the System of Objectified Judgement Analysis method. All seven available formulations were included in the analysis. Th... Read More about Rapid acting fentanyl formulations in breakthrough pain in cancer: drug selection by means of the System of Objectified Judgement Analysis.

Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults (2016)
Journal Article
Wiffen, P. J., Knaggs, R., Derry, S., Cole, P., Phillips, T., & Moore, R. A. (2016). Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults. Cochrane Database of Systematic Reviews, Article CD012227. https://doi.org/10.1002/14651858.CD012227.pub2

BACKGROUND Paracetamol, either alone or in combination with codeine or dihydrocodeine, is commonly used to treat chronic neuropathic pain. This review sought evidence for efficacy and harm from randomised double-blind studies. OBJECTIVES To... Read More about Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults.

Hydromorphone for cancer pain (2016)
Journal Article
Bao, Y. J., Hou, W., Kong, X. Y., Yang, L., Xia, J., Hua, B. J., & Knaggs, R. (2016). Hydromorphone for cancer pain. Cochrane Database of Systematic Reviews, Article CD011108. https://doi.org/10.1002/14651858.CD011108.pub2

BACKGROUND Cancer pain is an important and distressing symptom that tends to increase in frequency and intensity as the cancer advances. For people with advanced cancer, the prevalence of pain can be as high as 90%. It has been estimated that 30%... Read More about Hydromorphone for cancer pain.

Fentanyl for neuropathic pain in adults (2016)
Journal Article
Derry, S., Stannard, C., Cole, P., Wiffen, P. J., Knaggs, R., Aldington, D., & Moore, R. A. (2016). Fentanyl for neuropathic pain in adults. Cochrane Database of Systematic Reviews, Article CD011605. https://doi.org/10.1002/14651858.CD011605.pub2

BACKGROUND Opioid drugs, including fentanyl, are commonly used to treat neuropathic pain, and are considered effective by some professionals. Most reviews have examined all opioids together. This review sought evidence specifically for fentanyl, a... Read More about Fentanyl for neuropathic pain in adults.

Is tapentadol different from classical opioids?: a review of the evidence (2016)
Journal Article
Langford, R. M., Knaggs, R., Farquhar-Smith, P., & Dickenson, A. H. (2016). Is tapentadol different from classical opioids?: a review of the evidence. British Journal of Pain, 10(4), https://doi.org/10.1177/2049463716657363

Tapentadol is a single molecule able to deliver analgesia by two distinct mechanisms, a feature which differentiates it from many other analgesics. Pre-clinical data demonstrate two mechanisms of action: mu-opioid receptor agonist activity and noradr... Read More about Is tapentadol different from classical opioids?: a review of the evidence.

Hydromorphone for neuropathic pain in adults (2016)
Journal Article
Stannard, C., Gaskell, H., Derry, S., Aldington, D., Cole, P., Cooper, T. E., …Moore, R. A. (2016). Hydromorphone for neuropathic pain in adults. Cochrane Database of Systematic Reviews, Article CD011604. https://doi.org/10.1002/14651858.CD011604.pub2

BACKGROUND Opioid drugs, including hydromorphone, are commonly used to treat neuropathic pain, and are considered effective by some professionals. Most reviews have examined all opioids together. This review sought evidence specifically for hydrom... Read More about Hydromorphone for neuropathic pain in adults.

Describing the characteristics, treatment pathways, outcomes, and costs of people with persistent noncancer pain managed by community pain clinics and generating an indicative estimate of cost-effectiveness: feasibility study protocol (2016)
Journal Article
AlAujan, S., AlMazrou, S., Knaggs, R. D., & Elliott, R. A. (2016). Describing the characteristics, treatment pathways, outcomes, and costs of people with persistent noncancer pain managed by community pain clinics and generating an indicative estimate of cost-effectiveness: feasibility study protocol. Journal of Multidisciplinary Healthcare, 9, https://doi.org/10.2147/JMDH.S97904

BACKGROUND Low back pain (LBP) and fibromyalgia (FM), also known as chronic widespread pain (CWP), are highly prevalent chronic painful conditions that have substantial impact on patients, health care systems, and society. Diagnosis is complex and... Read More about Describing the characteristics, treatment pathways, outcomes, and costs of people with persistent noncancer pain managed by community pain clinics and generating an indicative estimate of cost-effectiveness: feasibility study protocol.

Buprenorphine for neuropathic pain in adults (2015)
Journal Article
Wiffen, P. J., Derry, S., Moore, R. A., Stannard, C., Aldington, D., Cole, P., & Knaggs, R. (2015). Buprenorphine for neuropathic pain in adults. Cochrane Database of Systematic Reviews, Article CD011603. https://doi.org/10.1002/14651858.CD011603.pub2

BACKGROUND Opioid drugs, including buprenorphine, are commonly used to treat neuropathic pain, and are considered effective by some professionals. Most reviews have examined all opioids together. This review sought evidence specifically for bupren... Read More about Buprenorphine for neuropathic pain in adults.

Acupuncture or low frequency infrared treatment for low back pain in Chinese patients: a discrete choice experiment (2015)
Journal Article
Chen, L.-C., Cheng, L.-J., Zhang, Y., He, Z., & Knaggs, R. (2015). Acupuncture or low frequency infrared treatment for low back pain in Chinese patients: a discrete choice experiment. PLoS ONE, 10(5), Article e0126912. https://doi.org/10.1371/journal.pone.0126912

Acupuncture is a popular but controversial treatment option for low back pain. In China, it is practised as traditional Chinese medicine; other treatment strategies for low back pain are commonly practised as Western medicine. Research on patient pre... Read More about Acupuncture or low frequency infrared treatment for low back pain in Chinese patients: a discrete choice experiment.