Delayed gastric emptying and reduced postprandial small bowel water content of equicaloric whole meal bread versus rice meals in healthy subjects: novel MRI insights

Marciani, Luca; Pritchard, Susan E.; Hellier-Woods, C.; Costigan, C.; Hoad, Caroline; Gowland, Penny A.; Spiller, Robin C.

doi:10.1038/ejcn.2013.78

All Outputs (65)

Quantification of gastrointestinal liquid volumes and distribution following a 240 mL dose of water in the fasted state (2014)
Journal Article
Mudie, D. M., Murray, K., Hoad, C. L., Pritchard, S. E., Garnett, M. C., Amidon, G. L., Gowland, P. A., Spiller, R. C., Amidon, G. E., & Marciani, L. (2014). Quantification of gastrointestinal liquid volumes and distribution following a 240 mL dose of water in the fasted state. Molecular Pharmaceutics, 11(9), 3039-3047. https://doi.org/10.1021/mp500210c

Previous imaging studies offered a snapshot of water distribution in fasted humans and showed that water in the small intestine is distributed in small pockets. This study aimed to quantify the volume and number of water pockets in the upper gut of f... Read More about Quantification of gastrointestinal liquid volumes and distribution following a 240 mL dose of water in the fasted state.

A low calorie morning meal prevents the decline of hepatic glycogen stores: a pilot in vivo 13C magnetic resonance study (2014)
Journal Article
Bawden, S., Stephenson, M., Ciampi, E., Hunter, K., Marciani, L., Spiller, R., …Gowland, P. (2014). A low calorie morning meal prevents the decline of hepatic glycogen stores: a pilot in vivo 13C magnetic resonance study. Food and Function, 5(9), 2237-2242. https://doi.org/10.1039/c4fo00050a

Previous studies have reported a meal-induced rise in hepatic glycogen stores from baseline levels following a fast and it is generally assumed that glycogen levels rise steadily following meals throughout the day. However, measurements are normally... Read More about A low calorie morning meal prevents the decline of hepatic glycogen stores: a pilot in vivo 13C magnetic resonance study.

A randomised trial of ondansetron for the treatment of irritable bowel syndrome with diarrhoea (2013)
Journal Article
Garsed, K., Chernova, J., Hastings, M., Lam, C., Marciani, L., Singh, G., Henry, A. P., Hall, I. P., Whorwell, P., & Spiller, R. C. (2014). A randomised trial of ondansetron for the treatment of irritable bowel syndrome with diarrhoea. Gut, 63(10), 1617-1625. https://doi.org/10.1136/gutjnl-2013-305989

Background: Irritable bowel syndrome with diarrhoea (IBS-D) is particularly debilitating due to urgency and episodic incontinence. Some 5-hydroxytryptamine 3 (5-HT3) receptor antagonists (5-HT3RAs) have proven effective but have serious side effects.... Read More about A randomised trial of ondansetron for the treatment of irritable bowel syndrome with diarrhoea.

Faecal microbiota composition and host–microbe cross-talk following gastroenteritis and in postinfectious irritable bowel syndrome (2013)
Journal Article
Jalanka-Tuovinen, J., Salojärvi, J., Salonen, A., Immonen, O., Garsed, K., Kelly, F. M., Zaitoun, A., Palva, A., Spiller, R. C., & De Vos, W. M. (2014). Faecal microbiota composition and host–microbe cross-talk following gastroenteritis and in postinfectious irritable bowel syndrome. Gut, 63(11), 1737-1745. https://doi.org/10.1136/gutjnl-2013-305994

Background: About 10% of patients with IBS report the start of the syndrome after infectious enteritis. The clinical features of postinfectious IBS (PI-IBS) resemble those of diarrhoea-predominant IBS (IBS-D). While altered faecal microbiota has been... Read More about Faecal microbiota composition and host–microbe cross-talk following gastroenteritis and in postinfectious irritable bowel syndrome.

Delayed gastric emptying and reduced postprandial small bowel water content of equicaloric whole meal bread versus rice meals in healthy subjects: novel MRI insights (2013)
Journal Article
Marciani, L., Pritchard, S. E., Hellier-Woods, C., Costigan, C., Hoad, C., Gowland, P. A., & Spiller, R. C. (2013). Delayed gastric emptying and reduced postprandial small bowel water content of equicaloric whole meal bread versus rice meals in healthy subjects: novel MRI insights. European Journal of Clinical Nutrition, 67(7), https://doi.org/10.1038/ejcn.2013.78

BACKGROUND/OBJECTIVES: Postprandial bloating is a common symptom in patients with functional gastrointestinal (GI) diseases. Whole meal bread (WMB) often aggravates such symptoms though the mechanisms are unclear. We used magnetic resonance imaging (... Read More about Delayed gastric emptying and reduced postprandial small bowel water content of equicaloric whole meal bread versus rice meals in healthy subjects: novel MRI insights.