All Outputs (3)

Peripheral INSL3 concentrations decline with age in a large population of Australian men (2006)
Journal Article
Anand-Ivell, R., Wohlgemuth, J., Haren, M. T., Hope, P. J., Hatzinikolas, G., Wittert, G., & Ivell, R. (2006). Peripheral INSL3 concentrations decline with age in a large population of Australian men. International Journal of Andrology, 29(6), 618-626. https://doi.org/10.1111/j.1365-2605.2006.00714.x

The novel peptide hormone insulin-like peptide 3 (INSL3) is a major secretory product of the Leydig cells of the testis, and in adult men is secreted into the blood, giving rise to circulating concentrations ranging from 0.5 to 2.5 ng/mL. We studied... Read More about Peripheral INSL3 concentrations decline with age in a large population of Australian men.

Expression of the insulin-like peptide 3 (INSL3) hormone-receptor (LGR8) system in the testis (2006)
Journal Article
Anand-Ivell, R. J., Relan, V., Balvers, M., Coiffec-Dorval, I., Fritsch, M., Bathgate, R. A., & Ivell, R. (2006). Expression of the insulin-like peptide 3 (INSL3) hormone-receptor (LGR8) system in the testis. Biology of Reproduction, 74(5), 945-953. https://doi.org/10.1095/biolreprod.105.048165

The new peptide hormone insulin-like peptide 3 (INSL3) is a member of the insulin-relaxin family, yet, unlike insulin, it signals through a new G-protein coupled receptor, LGR8, distantly related to the receptors for LH and FSH. INSL3 is produced in... Read More about Expression of the insulin-like peptide 3 (INSL3) hormone-receptor (LGR8) system in the testis.

Relaxin Signaling from Natural Receptors (2006)
Presentation / Conference Contribution
Ivell, R., Anand-Ivell, R., & Bartsch, O. (2004, September). Relaxin Signaling from Natural Receptors. Presented at Relaxin 2004, Fourth International Conference on Relaxin and Related Peptides, Wyoming, USA

The heterodimeric peptide hormone relaxin in most cells appears to signal through a G-protein-coupled receptor, LGR7. Whereas in artificial cell systems, made by transfection of receptor-expressing gene constructs into cells normally not presenting t... Read More about Relaxin Signaling from Natural Receptors.