Helix-bundle and C-terminal GPCR domains differentially influence GRK-specific functions and β-arrestin-mediated regulation
(2025)
Journal Article
Matthees, E. S. F., Haider, R. S., Klement, L., Reichel, M., Blum, N. K., Weitzel, V., Trüpschuch, T., Ziegler, C., Drube, J., Schulz, S., & Hoffmann, C. (2025). Helix-bundle and C-terminal GPCR domains differentially influence GRK-specific functions and β-arrestin-mediated regulation. Nature Communications, 16(1), Article 5430. https://doi.org/10.1038/s41467-025-61281-4
G protein-coupled receptors (GPCRs) orchestrate diverse physiological responses via signaling through G proteins, GPCR kinases (GRKs), and arrestins. While most G protein functions are well-established, the contributions of GRKs and arrestins remain... Read More about Helix-bundle and C-terminal GPCR domains differentially influence GRK-specific functions and β-arrestin-mediated regulation.