All Outputs (6)

Ion channels as therapeutic targets in high grade gliomas (2020)
Journal Article
Griffin, M., Khan, R., Basu, S., & Smith, S. (2020). Ion channels as therapeutic targets in high grade gliomas. Cancers, 12(10), Article 3068. https://doi.org/10.3390/cancers12103068

Glioblastoma multiforme (GBM) is a lethal brain cancer with an average survival of 14-15 months with maximal treatment. High grade gliomas (HGG) form a leading cause of CNS cancer-related death in children and adults due to the aggressive nature of t... Read More about Ion channels as therapeutic targets in high grade gliomas.

Ion channels as therapeutic targets in high grade gliomas (2020)
Journal Article
Smith, S., Griffin, M., & Khan, R. (2020). Ion channels as therapeutic targets in high grade gliomas. Cancers, 12(10), Article 3068. https://doi.org/10.3390/cancers12103068

Abstract: Glioblastoma multiforme (GBM) is a lethal brain cancer with an average survival of 14-15 months with maximal treatment. High grade gliomas (HGG) form a leading cause of CNS cancer-related death in children and adults due to the aggressive n... Read More about Ion channels as therapeutic targets in high grade gliomas.

Evaluation of extraction and normalisation strategies for the analysis of lipids in placental vessels (2018)
Journal Article
Sander, K. N., Hay, D. P., Broughton-Pipkin, F., Khan, R. N., & Barrett, D. A. (2018). Evaluation of extraction and normalisation strategies for the analysis of lipids in placental vessels. Journal of Pharmaceutical and Biomedical Analysis, 160, 297-300. https://doi.org/10.1016/j.jpba.2018.08.012

© 2018 The analysis of lipids in tough or fibrous biological tissues can be challenging due to difficulties in obtaining a representative sample following homogenisation of the tissue. Furthermore, the choice of normalisation method can have a major... Read More about Evaluation of extraction and normalisation strategies for the analysis of lipids in placental vessels.

Maternal obesity-induced decreases in plasma, hepatic and uterine polyunsaturated fatty acids during labour is reversed through improved nutrition at conception (2018)
Journal Article
Muir, R. D., Liu, G., Khan, R., Shmygol, A., Quenby, S., Gibson, R. A., …Elmes, M. (2018). Maternal obesity-induced decreases in plasma, hepatic and uterine polyunsaturated fatty acids during labour is reversed through improved nutrition at conception. Scientific Reports, 8, Article 3389. https://doi.org/10.1038/s41598-018-21809-9

Maternal obesity is associated with prolonged and dysfunctional labour, potentially through decreased synthesis of prostaglandins that stimulate myometrial contractions. We assessed the impact of maternal obesity on concentrations of precursor fatty... Read More about Maternal obesity-induced decreases in plasma, hepatic and uterine polyunsaturated fatty acids during labour is reversed through improved nutrition at conception.

The role of oxidative stress in antipsychotics induced ovarian toxicity (2017)
Journal Article
Elmorsy, E., Al-Ghafari, A., Aggour, A. M., Khan, R., & Amer, S. A. (2017). The role of oxidative stress in antipsychotics induced ovarian toxicity. Toxicology in Vitro, 44, https://doi.org/10.1016/j.tiv.2017.07.008

This study tested the hypothesis that oxidative stress could be an underlying mechanism for APs-induced ovarian cytotoxicity and reproductive dysfunction. Rat ovarian theca interstitial cells (TICs) were isolated and treated with four APs [chlorproma... Read More about The role of oxidative stress in antipsychotics induced ovarian toxicity.

Thecal cell sensitivity to luteinizing hormone and insulin in polycystic ovarian syndrome (2016)
Journal Article
Cadagan, D., Khan, R., & Amer, S. A. (2016). Thecal cell sensitivity to luteinizing hormone and insulin in polycystic ovarian syndrome. Reproductive Biology -Olsztyn-, 16(1), https://doi.org/10.1016/j.repbio.2015.12.006

This study examined whether a defect of steroid synthesis in ovarian theca cells may lead to the development of PCOS, through contributions to excess androgen secretion. Polycystic ovarian syndrome (PCOS) is one of the leading causes of infertilit... Read More about Thecal cell sensitivity to luteinizing hormone and insulin in polycystic ovarian syndrome.