All Outputs (31)

An Appraisal of Developments in Allium Sulfur Chemistry: Expanding the Pharmacopeia of Garlic (2019)
Journal Article
Rose, P., Moore, P. K., Whiteman, M., & Zhu, Y.-Z. (2019). An Appraisal of Developments in Allium Sulfur Chemistry: Expanding the Pharmacopeia of Garlic. Molecules, 24(21), Article 4006. https://doi.org/10.3390/molecules24214006

Alliums and allied plant species are rich sources of sulfur compounds that have effects on vascular homeostasis and the control of metabolic systems linked to nutrient metabolism in mammals. In view of the multiple biological effects ascribed to thes... Read More about An Appraisal of Developments in Allium Sulfur Chemistry: Expanding the Pharmacopeia of Garlic.

Amelioration of mitochondrial dysfunction in heart failure through S-sulfhydration of Ca2+/calmodulin-dependent protein kinase II (2018)
Journal Article
Wu, D., Hu, Q., Tan, B., Rose, P., Zhu, D., & Zhu, Y. Z. (2018). Amelioration of mitochondrial dysfunction in heart failure through S-sulfhydration of Ca2+/calmodulin-dependent protein kinase II. Redox Biology, 19, 250-262. https://doi.org/10.1016/j.redox.2018.08.008

Aims: Ca2+/calmodulin-dependent protein kinase II (CaMKII) plays a critical role in the development of heart failure and in the induction of myocardial mitochondrial injury. Recent evidence has shown that hydrogen sulfide (H2S), produced by the enzym... Read More about Amelioration of mitochondrial dysfunction in heart failure through S-sulfhydration of Ca2+/calmodulin-dependent protein kinase II.

Garlic and gaseous mediators (2018)
Journal Article
Rose, P., Moore, P. K., & Zhu, Y.-Z. (in press). Garlic and gaseous mediators. Trends in Pharmacological Sciences, https://doi.org/10.1016/j.tips.2018.03.009

Garlic (Allium sativum) and allied plant species are rich sources of sulfur compounds. Major roles for garlic and its sulfur constituents include the regulation of vascular homeostasis and the control of metabolic systems linked to nutrient metabolis... Read More about Garlic and gaseous mediators.

ZYZ-168 alleviates cardiac fibrosis after myocardial infarction through inhibition of ERK1/2-dependent ROCK1 activation (2017)
Journal Article
Luo, S., Hieu, T. B., Ma, F., Yu, Y., Cao, Z., Wang, M., …Zhu, Y. Z. (in press). ZYZ-168 alleviates cardiac fibrosis after myocardial infarction through inhibition of ERK1/2-dependent ROCK1 activation. Scientific Reports, 7, Article 43242. https://doi.org/10.1038/srep43242

Selective treatments for myocardial infarction (MI) induced cardiac fibrosis are lacking. In this study, we focus on the therapeutic potential of a synthetic cardio-protective agent named ZYZ-168 towards MI-induced cardiac fibrosis and try to reveal... Read More about ZYZ-168 alleviates cardiac fibrosis after myocardial infarction through inhibition of ERK1/2-dependent ROCK1 activation.

H2S biosynthesis and catabolism: new insights from molecular studies (2016)
Journal Article
Rose, P., Moore, P. K., & Zhu, Y. Z. (2017). H2S biosynthesis and catabolism: new insights from molecular studies. Cellular and Molecular Life Sciences, 74(8), 1391-1412. https://doi.org/10.1007/s00018-016-2406-8

Hydrogen sulfide (H2S) has profound biological effects within living organisms and is now increasingly being considered alongside other gaseous signalling molecules, such as nitric oxide (NO) and carbon monoxide (CO). Conventional use of pharmacologi... Read More about H2S biosynthesis and catabolism: new insights from molecular studies.

GYY4137, a Novel Water-Soluble, H2S-Releasing Molecule (2015)
Book Chapter
Rose, P., Dymock, B. W., & Moore, P. K. (2015). GYY4137, a Novel Water-Soluble, H2S-Releasing Molecule. In Hydrogen Sulfide in Redox Biology, Part A (143-167). Elsevier. https://doi.org/10.1016/bs.mie.2014.11.014

Hydrogen sulfide (H2S) is now recognized as the so called "third gasotransmitter" taking its place alongside nitric oxide and carbon monoxide. In recent years, H2S has been reported to exhibit a diverse range of pharmacological effects in biological... Read More about GYY4137, a Novel Water-Soluble, H2S-Releasing Molecule.

Hydrogen Sulfide Is an Endogenous Regulator of Aging in Caenorhabditis elegans (2014)
Journal Article
Qabazard, B., Li, L., Gruber, J., Peh, M. T., Ng, L. F., Kumar, S. D., …Moore, P. K. (2014). Hydrogen Sulfide Is an Endogenous Regulator of Aging in Caenorhabditis elegans. Antioxidants and Redox Signaling, 20(16), 2621-2630. https://doi.org/10.1089/ars.2013.5448

Aims:

To investigate the role of endogenous hydrogen sulfide (H 2S) in the control of aging and healthspan of Caenorhabditis elegans.

Results:

We show that the model organism, C. elegans, synthesizes H 2S. Three H2S-synthesizing enzymes a... Read More about Hydrogen Sulfide Is an Endogenous Regulator of Aging in Caenorhabditis elegans.

Effect of 3 to 5 years of scheduled CEA and CT follow-upto detect recurrence of colorectal cancer The FACS Randomized Clinical Trial (2014)
Journal Article
Primrose, J. N., Perera, R., Gray, A., Rose, P., Fuller, A., Corkhill, A., …FACS Trial Investigators. (2014). Effect of 3 to 5 years of scheduled CEA and CT follow-upto detect recurrence of colorectal cancer The FACS Randomized Clinical Trial. Journal of the American Medical Association, 311(3), https://doi.org/10.1001/jama.2013.285718

IMPORTANCE Intensive follow-up after surgery for colorectal cancer is common practice but is based on limited evidence.
OBJECTIVE To assess the effect of scheduled blood measurement of carcinoembryonic antigen (CEA) and computed tomography (CT) as f... Read More about Effect of 3 to 5 years of scheduled CEA and CT follow-upto detect recurrence of colorectal cancer The FACS Randomized Clinical Trial.

Future climate alleviates stress impact on grassland productivity through altered antioxidant capacity (2013)
Journal Article
Naudts, K., Van den Berge, J., Farfan, E., Rose, P., AbdElgawad, H., Ceulemans, R., …Nijs, I. (2014). Future climate alleviates stress impact on grassland productivity through altered antioxidant capacity. Environmental and Experimental Botany, 99, 150-158. https://doi.org/10.1016/j.envexpbot.2013.11.003

Predicting future ecosystem functioning requires a mechanistic understanding of how plants cope with different stressors under future climate conditions with elevated CO2 concentrations and warmer temperatures. Nonetheless, studies of stress response... Read More about Future climate alleviates stress impact on grassland productivity through altered antioxidant capacity.

Hydrogen sulfide and cell signaling (2011)
Journal Article
Li, L., Rose, P., & Moore, P. K. (2011). Hydrogen sulfide and cell signaling. Annual Review of Pharmacology and Toxicology, 51, 169-187. https://doi.org/10.1146/annurev-pharmtox-010510-100505

Hydrogen sulfide (H2S) is a gaseous mediator synthesized from cysteine by cystathionine λ lyase (CSE) and other naturally occurring enzymes. Pharmacological experiments usingH2S donors and genetic experiments using CSE knockout mice suggest important... Read More about Hydrogen sulfide and cell signaling.

Hypoxia-inducible factor-1α is involved in the pro-angiogenic effect of hydrogen sulfide under hypoxic stress (2010)
Journal Article
Liu, X. H., Pan, L. L., Zhuo, Y., Gong, Q. H., Rose, P., & Zhu, Y. Z. (2010). Hypoxia-inducible factor-1α is involved in the pro-angiogenic effect of hydrogen sulfide under hypoxic stress. Biological and Pharmaceutical Bulletin, 33(9), 1550-1554. https://doi.org/10.1248/bpb.33.1550

Hydrogen sulfide (H2S) is known to have pro-angiogenic properties in mammals. In this study, we examined H2S played the role in pro-angiogenesis mediated by hypoxia-inducible factor (HIF)-1α under hypoxic conditions. Rat brain capillary endothelial c... Read More about Hypoxia-inducible factor-1α is involved in the pro-angiogenic effect of hydrogen sulfide under hypoxic stress.