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All Outputs (109)

A realist review of acute pain management in children and young people attended by ambulance (2025)
Journal Article
Whitley, G., Nicholls, G., Baliousis, M., Bujor, T., Eaton, G., Hodgson, J., Leighton, P., Lord, B., Ortega, M., Redsell, S., Siriwarden, N., & Sumera, K. (2025). A realist review of acute pain management in children and young people attended by ambulance. Paramedicine, https://doi.org/10.1177/27536386251356690

Acute pain management in children and young people (CYP) attended by ambulance services is a significant challenge due to the complex nature of pain, the variation of approach needed across the age range, and the unpredictability of the environment.... Read More about A realist review of acute pain management in children and young people attended by ambulance.

P125 Online survey of perspectives on lung imaging use in cystic fibrosis (2025)
Journal Article
Beever, D., Leighton, P., Howells, L., & Prayle, A. (2025). P125 Online survey of perspectives on lung imaging use in cystic fibrosis. Journal of Cystic Fibrosis, 24(Supplement 1), S106. https://doi.org/10.1016/j.jcf.2025.03.143

Objectives
As an emerging technology in cystic fibrosis (CF), there is potential for misunderstanding of lung magnetic resonance imaging (MRI) scan results. As the initial stage of a project to develop a results communication toolkit, we sought to e... Read More about P125 Online survey of perspectives on lung imaging use in cystic fibrosis.

Developing a core outcome set for hand flexor tendon injuries: a systematic review of treatment outcomes (2025)
Journal Article
Deshmukh, S. R., Jerosch-Herold, C., Miller, L., Fuller, A., See, A., Leighton, P., & Karantana, A. (2025). Developing a core outcome set for hand flexor tendon injuries: a systematic review of treatment outcomes. Journal of Hand Surgery (European Volume), https://doi.org/10.1177/17531934251342732

This study identifies the outcome domains used in recently published studies on the treatment of hand flexor tendon injuries in adults in order to inform the development of a core outcome set. Seven databases were searched from January 2013 to March... Read More about Developing a core outcome set for hand flexor tendon injuries: a systematic review of treatment outcomes.

Minimum Important Change for the Patient Evaluation Measure in patients with finger fractures and joint injuries (2025)
Journal Article
Mousoulis, C., Trickett, R. W., Thomas, K. S., Leighton, P., & Karantana, A. (2025). Minimum Important Change for the Patient Evaluation Measure in patients with finger fractures and joint injuries. Journal of Hand Surgery (European Volume), https://doi.org/10.1177/17531934251331727

The Minimum Important Change of the Patient Evaluation Measure for patients recovering from a finger fracture or joint injury was estimated to aid the design of future trials. Data from the Patient Outcomes for Finger Fractures and Joint Injuries pro... Read More about Minimum Important Change for the Patient Evaluation Measure in patients with finger fractures and joint injuries.

Lessons from the PROTECT-CH COVID-19 platform trial in care homes (2025)
Journal Article
Bath, P. M., Ball, J., Boyd, M., Gage, H., Glover, M., Godfrey, M., Guthrie, B., Hewitt, J., Howard, R., Jaki, T., Juszczak, E., Lasserson, D., Leighton, P., Leyland, V., Shen Lim, W., Logan, P., Meakin, G., Montgomery, A., Ogollah, R., Passmore, P., …Gordon, A. L. (2025). Lessons from the PROTECT-CH COVID-19 platform trial in care homes. Health Technology Assessment, https://doi.org/10.3310/MTRS8833

Background
Coronavirus disease-2019 was associated with significant mortality and morbidity in care homes in 2020–1. Repurposed antiviral drugs might reduce morbidity and mortality through reducing viral transmission, infection, replication and infl... Read More about Lessons from the PROTECT-CH COVID-19 platform trial in care homes.

Supporting self-care for eczema in the community: the Eczema Care Online research programme including two RCTs (2025)
Journal Article
Muller, I., Stuart, B., Sach, T., Yardley, L., Greenwell, K., Becque, T., Leighton, P., Howells, L., Harvey, J., Hooper, J., Steele, M., Sivyer, K., Ghio, D., Teasdale, E., Axon, E., Lax, S., Clarke, H., Onoja, M., Ahmed, A., Griffiths, G., …Santer, M. (2025). Supporting self-care for eczema in the community: the Eczema Care Online research programme including two RCTs. Programme Grants for Applied Research, 13(3), https://doi.org/10.3310/FNHD8546

Background
Eczema is a common condition with significant impact on quality of life. The main cause of treatment failure is non-use of prescribed treatments because treatments are time-consuming to apply; they may sting when first applied to inflamed... Read More about Supporting self-care for eczema in the community: the Eczema Care Online research programme including two RCTs.

A qualitative interview study exploring patients' views and experiences of treatment for hidradenitis suppurativa in the UK (2025)
Journal Article
Howells, L., Leighton, P., Thomas, K. S., Collier, F., Gibbons, A., Harris, C., Hood, K., Riaz, M., Rodrigues, J., Stanton, H., Thomas-Jones, E., & Ingram, J. R. (2025). A qualitative interview study exploring patients' views and experiences of treatment for hidradenitis suppurativa in the UK. British Journal of Dermatology, 193(1), 85-92. https://doi.org/10.1093/bjd/ljaf046

Background
Hidradenitis suppurativa (HS) is a long-term skin condition where evidence for management after first-line treatment fails is limited and practice varies across the UK. Medical and surgical treatment options are potential avenues of treat... Read More about A qualitative interview study exploring patients' views and experiences of treatment for hidradenitis suppurativa in the UK.

Evidence to practice – lessons learnt in developing an implementation strategy for an online digital health intervention (Eczema Care Online) (2025)
Journal Article
Howells, L., Thomas, K. S., Santer, M., Muller, I., Greenwell, K., Roberts, A., Williams, H. C., Harvey, J., Lax, S. J., Rogers, N. K., Sach, T. H., Lawton, S., Steele, M., Sivyer, K., Hooper, J., Ahmed, A., Wilczynska, S., Langan, S., & Leighton, P. (2025). Evidence to practice – lessons learnt in developing an implementation strategy for an online digital health intervention (Eczema Care Online). BMC Health Services Research, 25(1), Article 187. https://doi.org/10.1186/s12913-024-12179-2

Background
Eczema Care Online (www.EczemaCareOnline.org.uk/) is an online self-management toolkit which includes tailored content for young people (13–25 years) and for parents of children that have eczema (0–12 years). Testing in two randomised con... Read More about Evidence to practice – lessons learnt in developing an implementation strategy for an online digital health intervention (Eczema Care Online).

Collagenase injection versus limited fasciectomy surgery to treat Dupuytren's contracture in adult patients in the UK: DISC, a non-inferiority RCT and economic evaluation (2024)
Journal Article
Dias, J., Tharmanathan, P., Arundel, C., Welch, C., Wu, Q., Leighton, P., Armaou, M., Corbacho, B., Johnson, N., James, S., Cooke, J., Bainbridge, C., Craigen, M., Warwick, D., Brady, S., Flett, L., Jones, J., Knowlson, C., Watson, M., Keding, A., …Torgerson, D. (2024). Collagenase injection versus limited fasciectomy surgery to treat Dupuytren's contracture in adult patients in the UK: DISC, a non-inferiority RCT and economic evaluation. Health Technology Assessment, 28(78), 1-262. https://doi.org/10.3310/kgxd8528

Background: Dupuytren's contracture is caused by nodules and cords which pull the fingers towards the palm of the hand. Treatments include limited fasciectomy surgery, collagenase injection and needle fasciotomy. There is limited evidence comparing l... Read More about Collagenase injection versus limited fasciectomy surgery to treat Dupuytren's contracture in adult patients in the UK: DISC, a non-inferiority RCT and economic evaluation.

Collagenase Injection versus Limited Fasciectomy for Dupuytren’s Contracture (2024)
Journal Article
Dias, J., Tharmanathan, P., Arundel, C., Welch, C., Math, M., Wu, Q., Leighton, P., Armaou, M., Johnson, N., James, S., Cooke, J., Bainbridge, L., Craigen, M., Warwick, D., Brady, S., Flett, L. G., Jones, J., Knowlson, C. N., Watson, M., Keding, A., …Torgerson, D. (2024). Collagenase Injection versus Limited Fasciectomy for Dupuytren’s Contracture. New England Journal of Medicine, 391(16), 1499-1510. https://doi.org/10.1056/NEJMoa2312631

Background
Treatments for Dupuytren’s contracture include limited fasciectomy and collagenase injection. Comparisons of the effectiveness of these treatments have been limited.

Methods
We performed an unblinded, multicenter, pragmatic, two-group... Read More about Collagenase Injection versus Limited Fasciectomy for Dupuytren’s Contracture.

‘Going through the motions’; a rich account of the complexity of the anterior cruciate ligament reconstruction pathway, a UK qualitative study (2024)
Journal Article
Carter, H. M., Beard, D. J., Leighton, P., Moffatt, F., Smith, B. E., Webster, K. E., & Logan, P. (2024). ‘Going through the motions’; a rich account of the complexity of the anterior cruciate ligament reconstruction pathway, a UK qualitative study. BMJ Open, 14(9), Article e079468. https://doi.org/10.1136/bmjopen-2023-079468

Objectives: This study aimed to understand the lived experiences of patients on the anterior cruciate ligament reconstruction (ACLR) pathway up to 3 months before, 3 months after and 1 year after surgery. Study objectives were to explore (1) patient... Read More about ‘Going through the motions’; a rich account of the complexity of the anterior cruciate ligament reconstruction pathway, a UK qualitative study.

231 Violence and abuse towards staff by patients and the public in general practice: a scoping review (2024)
Journal Article
Chou, S., Sawyers, L., Tyrrell, E., Leighton, P., & Kendrick, D. (2024). 231 Violence and abuse towards staff by patients and the public in general practice: a scoping review. Injury Prevention, https://doi.org/10.1136/injuryprev-2024-SAFETY.118

Background Violence and abuse in healthcare settings is a growing concern. Staff are more likely to experience violence initiated by patients and the public than by their own colleagues. General practice may be more exposed to such behaviours than ho... Read More about 231 Violence and abuse towards staff by patients and the public in general practice: a scoping review.

233 The occurrence of violence and abuse towards staff by patients and the public in general practice since COVID-19 in England (2024)
Journal Article
Chou, S., Tyrrell, E., Leighton, P., & Kendrick, D. (2024). 233 The occurrence of violence and abuse towards staff by patients and the public in general practice since COVID-19 in England. Injury Prevention, 30(Suppl 1), https://doi.org/10.1136/injuryprev-2024-SAFETY.120

Background In 2021, 37% of UK doctors reported experiencing direct verbal abuse from patients and/or the public in the last month. Of these 37%, 51% were general practitioners (GPs) and 30% were hospital doctors. Two-thirds of GPs said their experien... Read More about 233 The occurrence of violence and abuse towards staff by patients and the public in general practice since COVID-19 in England.

improving Pain mAnagement for childreN and young people attendeD by Ambulance (PANDA): protocol for a realist review [version 1; peer review: 2 approved with reservations] (2024)
Journal Article
Nicholls, G., Eaton, G., Ortega, M., Sumera, K., Baliousis, M., Hodgson, J., Laparidou, D., Siriwardena, A. N., Leighton, P., Redsell, S., Lord, B., Bujor, T., & Whitley, G. A. (2024). improving Pain mAnagement for childreN and young people attendeD by Ambulance (PANDA): protocol for a realist review [version 1; peer review: 2 approved with reservations]. NIHR Open Research, 4, Article 42. https://doi.org/10.3310/nihropenres.13627.1

Background
Each year in England, 450,000 children and young people (CYP) under 18 years of age are transported by ambulance to emergency departments. Approximately 20% of these suffer acute pain caused by illness or injury. Pain is a highly complex... Read More about improving Pain mAnagement for childreN and young people attendeD by Ambulance (PANDA): protocol for a realist review [version 1; peer review: 2 approved with reservations].

A multifaceted and standardized approach is needed to improve acne severity assessment in clinical practice: an online survey of UK health professionals (2024)
Journal Article
Masterson, N., Burden-Teh, E., Healy, E., Hepburn, T., Layfield, C., Layton, A., Leighton, P., Leng, S., Mitchell, E., Northover, G., Penzer-Hick, R., Price, W., Radley, K., Ramesh, G., Ravenscroft, J. C., Sach, T., Sadiq, S., Santer, M., Thomas, K. S., Thompson, A., …the Acne-ID Trial Development Team. (2025). A multifaceted and standardized approach is needed to improve acne severity assessment in clinical practice: an online survey of UK health professionals. Clinical and Experimental Dermatology, 50(1), 158-160. https://doi.org/10.1093/ced/llae180

Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service (2024)
Journal Article
Radford, S. J., Abdul-Aema, B., Tench, C., Leighton, P., Coad, J., & Moran, G. W. (2024). Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service. Scandinavian Journal of Gastroenterology, 59(6), 683-689. https://doi.org/10.1080/00365521.2024.2330588

Background: Imaging is used to monitor disease activity in small bowel Crohn’s disease (CD). Magnetic Resonance Enterography is often employed as a first modality in the United Kingdom for assessment and monitoring; however, waiting times, cost, pati... Read More about Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service.

Perspectives of community pharmacy staff on commonly encountered skin conditions and the key challenges towards enhancing their role in dermatology (2024)
Journal Article
Shariff, Z., Harvey, J., Leighton, P., Boyd, M., Ridd, M., Santer, M., Tucker, R., & Maidment, I. (2024). Perspectives of community pharmacy staff on commonly encountered skin conditions and the key challenges towards enhancing their role in dermatology. Skin Health and Disease, 4(2), Article e369. https://doi.org/10.1002/ski2.369

This research letter discusses the perspectives of community pharmacy staff on commonly encountered skin conditions and the key challenges towards enhancing their role in this area. A mixed methods online survey was created, and a total of 174 commun... Read More about Perspectives of community pharmacy staff on commonly encountered skin conditions and the key challenges towards enhancing their role in dermatology.

Feasibility of Daily Pain Measurement Using Text Messages in Hidradenitis Suppurativa Clinical Trials; Data from THESEUS Study (2024)
Journal Article
Hasan, S. B., Bates, J., Cannings-John, R., Collier, F., Evans, J., Gibbons, A., Harris, C., Howells, L., Hood, K., Howes, R., Leighton, P., Riaz, M., Rodrigues, J., Stanton, H., Thomas, K. S., Thomas-Jones, E., & Ingram, J. R. (2024). Feasibility of Daily Pain Measurement Using Text Messages in Hidradenitis Suppurativa Clinical Trials; Data from THESEUS Study. British Journal of Dermatology, 90(5), 775–777. https://doi.org/10.1093/bjd/ljae057

Cost-effectiveness of two online interventions supporting self-care for eczema for parents/carers and young people (2024)
Journal Article
Sach, T. H., Onoja, M., Clarke, H., Santer, M., Muller, I., Becque, T., Stuart, B., Hooper, J., Steele, M., Wilczynska, S., Ridd, M. J., Roberts, A., Ahmed, A., Yardley, L., Little, P., Greenwell, K., Sivyer, K., Nuttall, J., Griffiths, G., Lawton, S., …Thomas, K. S. (2024). Cost-effectiveness of two online interventions supporting self-care for eczema for parents/carers and young people. European Journal of Health Economics, 25(7), 1165–1176. https://doi.org/10.1007/s10198-023-01649-9

Objective: To estimate the cost-effectiveness of online behavioral interventions (EczemaCareOnline.org.uk) designed to support eczema self-care management for parents/carers and young people from an NHS perspective. Methods: Two within-trial economic... Read More about Cost-effectiveness of two online interventions supporting self-care for eczema for parents/carers and young people.