All Outputs (7)

Biomaterial-based platforms for tumour tissue engineering (2023)
Journal Article
Curvello, R., Kast, V., Ordóñez-Morán, P., Mata, A., & Loessner, D. (2023). Biomaterial-based platforms for tumour tissue engineering. Nature Reviews Materials, 8, 314–330. https://doi.org/10.1038/s41578-023-00535-3

Tissue engineering has produced innovative tools for cancer research. 3D cancer models based on molecularly designed biomaterials aim to harness the dimensionality and biomechanical and biochemical properties of tumour tissues. However, to date, desp... Read More about Biomaterial-based platforms for tumour tissue engineering.

Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers (2022)
Journal Article
Alblihy, A., Ali, R., Algethami, M., Shoqafi, A., Toss, M. S., Brownlie, J., …Madhusudan, S. (2022). Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers. npj Precision Oncology, 6(1), https://doi.org/10.1038/s41698-022-00298-0

Platinum resistance is a clinical challenge in ovarian cancer. Platinating agents induce DNA damage which activate Mre11 nuclease directed DNA damage signalling and response (DDR). Upregulation of DDR may promote chemotherapy resistance. Here we have... Read More about Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers.

Biomaterials for intestinal organoid technology and personalized disease modelling (2021)
Journal Article
Hirota, A., AlMusawi, S., Nateri, A. S., Ordóñez-Moran, P., & Imajo, M. (2021). Biomaterials for intestinal organoid technology and personalized disease modelling. Acta Biomaterialia, 132, 272-287. https://doi.org/10.1016/j.actbio.2021.05.010

Recent advances in intestinal organoid technologies have paved the way for in vitro recapitulation of the homeostatic renewal of adult tissues, tissue or organ morphogenesis during development, and pathogenesis of many disorders. In vitro modelling o... Read More about Biomaterials for intestinal organoid technology and personalized disease modelling.

Genomic instability profiles at the single cell level in mouse colorectal cancers of defined genotypes (2021)
Journal Article
Dionellis, V. S., Norkin, M., Karamichali, A., Rossetti, G. G., Huelsken, J., Ordonez-Moran, P., & Halazonetis, T. D. (2021). Genomic instability profiles at the single cell level in mouse colorectal cancers of defined genotypes. Cancers, 13(6), Article 1267. https://doi.org/10.3390/cancers13061267

The genomes of many human CRCs have been sequenced, revealing a large number of genetic alterations. However, the molecular mechanisms underlying the accumulation of these alterations are still being debated. In this study, we examined colorectal tum... Read More about Genomic instability profiles at the single cell level in mouse colorectal cancers of defined genotypes.

Designer matrices for intestinal stem cell and organoid culture (2016)
Journal Article
Gjorevski, N., Sachs, N., Manfrin, A., Giger, S., Bragina, M. E., Ordóñez-Morán, P., …Lutolf, M. P. (2016). Designer matrices for intestinal stem cell and organoid culture. Nature, 539(7630), 560-564. https://doi.org/10.1038/nature20168

Epithelial organoids recapitulate multiple aspects of real organs, making them promising models of organ development, function and disease. However, the full potential of organoids in research and therapy has remained unrealized, owing to the poorly... Read More about Designer matrices for intestinal stem cell and organoid culture.

HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer (2015)
Journal Article
Ordóñez-Morán, P., Dafflon, C., Imajo, M., Nishida, E., & Huelsken, J. (2015). HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer. Cancer Cell, 28(6), 815-829. https://doi.org/10.1016/j.ccell.2015.11.001

Hierarchical organization of tissues relies on stem cells, which either self-renew or produce committed progenitors predestined for lineage differentiation. Here we identify HOXA5 as an important repressor of intestinal stem cell fate in vivo and ide... Read More about HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer.

SPROUTY2 is a β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer (2013)
Journal Article
Ordóñez-Morán, P., Irmisch, A., Barbáchano, A., Chicote, I., Tenbaum, S., Landolfi, S., …Pálmer, H. G. (2014). SPROUTY2 is a β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer. Oncogene, 33(15), 1975-1985. https://doi.org/10.1038/onc.2013.140

SPROUTY2 (SPRY2) is an intracellular regulator of receptor tyrosine kinase signaling involved in cell growth, differentiation and tumorigenesis. Here, we show that SPRY2 is a target gene of the Wnt/β-catenin pathway that is abnormally activated in mo... Read More about SPROUTY2 is a β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer.