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All Outputs (9)

Real‐world persistence of multiple sclerosis disease‐modifying therapies (2024)
Journal Article
Tallantyre, E. C., Dobson, R., Froud, J. L. J., St John, F. A., Anderson, V. M., Arun, T., Buckley, L., Evangelou, N., Ford, H. L., Galea, I., George, S., Gray, O. M., Hibbert, A. M., Hu, M., Hughes, S. E., Ingram, G., Kalra, S., Lim, C. E., Mathews, J. T. M., McDonnell, G. V., …Robertson, N. P. (2024). Real‐world persistence of multiple sclerosis disease‐modifying therapies. European Journal of Neurology, 31(7), Article e16289. https://doi.org/10.1111/ene.16289

Background and purpose: Treatment persistence is the continuation of therapy over time. It reflects a combination of treatment efficacy and tolerability. We aimed to describe real‐world rates of persistence on disease‐modifying therapies (DMTs) for p... Read More about Real‐world persistence of multiple sclerosis disease‐modifying therapies.

The Impact of COVID-19 on the Employment of People With Multiple Sclerosis: A Multi-Methods Study (2024)
Journal Article
De Dios Perez, B., Pritchard, C., Powers, K., das Nair, R., Evangelou, N., Ford, H., …Radford, K. (2024). The Impact of COVID-19 on the Employment of People With Multiple Sclerosis: A Multi-Methods Study. International Journal of Ms Care, 26(Q3), 174-186. https://doi.org/10.7224/1537-2073.2023-049

Background: The COVID-19 pandemic led to approximately half of the working population in the United Kingdom being unable to work temporarily. This study aims to understand the employment needs and experiences of people with multiple sclerosis (MS) in... Read More about The Impact of COVID-19 on the Employment of People With Multiple Sclerosis: A Multi-Methods Study.

A qualitative study exploring how vocational rehabilitation for people with multiple sclerosis can be integrated within existing healthcare services in the United Kingdom (2024)
Preprint / Working Paper
De Dios Perez, B., Booth, V., das Nair, R., Evangelou, N., Hassard, J., Ford, H. L., …Radford, K. A qualitative study exploring how vocational rehabilitation for people with multiple sclerosis can be integrated within existing healthcare services in the United Kingdom

Background To explore how a vocational rehabilitation (VR) intervention can be integrated within existing healthcare services for people with multiple sclerosis (MS) in the United Kingdom (UK) National Health Service (NHS). Methods Data from 37... Read More about A qualitative study exploring how vocational rehabilitation for people with multiple sclerosis can be integrated within existing healthcare services in the United Kingdom.

Risk of COVID-19 in people with multiple sclerosis who are seronegative following vaccination (2023)
Journal Article
Zaloum, S. A., Wood, C. H., Tank, P., Upcott, M., Vickaryous, N., Anderson, V., …Tallantyre, E. C. (2023). Risk of COVID-19 in people with multiple sclerosis who are seronegative following vaccination. Multiple Sclerosis Journal, 29(8), 979-989. https://doi.org/10.1177/13524585231185247

Background: People with multiple sclerosis (pwMS) treated with certain disease-modifying therapies (DMTs) have attenuated IgG response following COVID-19 vaccination; however, the clinical consequences remain unclear. Objective: To report CO... Read More about Risk of COVID-19 in people with multiple sclerosis who are seronegative following vaccination.

Real-world annualized relapse rates from contemporary multiple sclerosis clinics in the UK: a retrospective multicentre cohort study (2023)
Journal Article
Papathanasiou, A., Hibbert, A., Tallantyre, E., Harding, K., Selvam, A. P., Morgan, M., …Evangelou, N. (2023). Real-world annualized relapse rates from contemporary multiple sclerosis clinics in the UK: a retrospective multicentre cohort study. Neurological Sciences, 44(10), 3629-3635. https://doi.org/10.1007/s10072-023-06838-1

Background: Annualized relapse rate (ARR) is used as an outcome measure in multiple sclerosis (MS) clinical trials. Previous studies demonstrated that ARR has reduced in placebo groups between 1990 and 2012. This study aimed to estimate real-world AR... Read More about Real-world annualized relapse rates from contemporary multiple sclerosis clinics in the UK: a retrospective multicentre cohort study.

ADAMS project: a genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis based in the UK. (2023)
Journal Article
Jacobs, B. M., Schalk, L., Dunne, A., Scalfari, A., Nandoskar, A., Gran, B., …Dobson, R. (2023). ADAMS project: a genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis based in the UK. BMJ Open, 13(5), Article e071656. https://doi.org/10.1136/bmjopen-2023-071656

Purpose Genetic studies of multiple sclerosis (MS) susceptibility and severity have focused on populations of European ancestry. Studying MS genetics in other ancestral groups is necessary to determine the generalisability of these findings. The gene... Read More about ADAMS project: a genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis based in the UK..

An update on the use of sphingosine 1-phosphate receptor modulators for the treatment of relapsing multiple sclerosis (2023)
Journal Article
Dumitrescu, L., Papathanasiou, A., Coclitu, C., Garjani, A., Evangelou, N., Constantinescu, C. S., …Tanasescu, R. (2023). An update on the use of sphingosine 1-phosphate receptor modulators for the treatment of relapsing multiple sclerosis. Expert Opinion on Pharmacotherapy, 24(4), 495-509. https://doi.org/10.1080/14656566.2023.2178898

Multiple sclerosis (MS) is an immune-mediated disorder of the CNS manifested by recurrent attacks of neurological symptoms (related to focal inflammation) and gradual disability accrual (related to progressive neurodegeneration and neuroinflammation)... Read More about An update on the use of sphingosine 1-phosphate receptor modulators for the treatment of relapsing multiple sclerosis.

Developing a Patient Care Pathway for Emotional Support around the point of Multiple Sclerosis diagnosis: A Stakeholder Engagement Study (2023)
Journal Article
Tindall, T., Topcu, G., Thomas, S., Bale, C., Evangelou, N., Drummond, A., & das Nair, R. (2023). Developing a Patient Care Pathway for Emotional Support around the point of Multiple Sclerosis diagnosis: A Stakeholder Engagement Study. Health Expectations, 26(2), 858-868. https://doi.org/10.1111/hex.13711

Background: Diagnosing multiple sclerosis (MS) can be a lengthy process, which can impact psychological wellbeing, condition management, and future engagement with health services. Therefore, providing timely and appropriate emotional support may imp... Read More about Developing a Patient Care Pathway for Emotional Support around the point of Multiple Sclerosis diagnosis: A Stakeholder Engagement Study.