Chromosomal integration of the pSOL1 megaplasmid of Clostridium acetobutylicum for continuous and stable advanced biofuels production
(2024)
Journal Article
Ehsaan, M., Yoo, M., Kuit, W., Foulquier, C., Soucaille, P., & Minton, N. P. (2024). Chromosomal integration of the pSOL1 megaplasmid of Clostridium acetobutylicum for continuous and stable advanced biofuels production. Nature Microbiology, 9(7), 1655-1660. https://doi.org/10.1038/s41564-024-01714-w
Biofuel production by Clostridium acetobutylicum is compromised by strain degeneration due to loss of its pSOL1 megaplasmid. Here we used engineering biology to stably integrate pSOL1 into the chromosome together with a synthetic isopropanol pathway.... Read More about Chromosomal integration of the pSOL1 megaplasmid of Clostridium acetobutylicum for continuous and stable advanced biofuels production.