All Outputs (6)

Disassociating cerebral vasomotion from low frequency spontaneous neurovascular coupling (2025)
Preprint / Working Paper
Wang, R., Patel, P., Boorman, L., Okun, M., Howarth, C., & Berwick, J. (2025). Disassociating cerebral vasomotion from low frequency spontaneous neurovascular coupling

Vasomotion, vascular oscillations at ∼0.1 Hz, may serve as a biomarker and therapeutic target for neurodegenerative diseases, but its origins, structure across brain vasculature, and correlation with neural activity remain unclear. This study examine... Read More about Disassociating cerebral vasomotion from low frequency spontaneous neurovascular coupling.

Multi-day neuron tracking in high-density electrophysiology recordings using earth mover's distance (2024)
Journal Article
Yuan, A., Colonell, J., Lebedeva, A., Okun, M., Charles, A., & Harris, T. D. (2024). Multi-day neuron tracking in high-density electrophysiology recordings using earth mover's distance. eLife, 12, Article 92495. https://doi.org/10.7554/eLife.92495.3

Accurate tracking of the same neurons across multiple days is crucial for studying changes in neuronal activity during learning and adaptation. Advances in high-density extracellular electrophysiology recording probes, such as Neuropixels, provide a... Read More about Multi-day neuron tracking in high-density electrophysiology recordings using earth mover's distance.

Brain state transitions primarily impact the spontaneous rate of slow-firing neurons (2023)
Journal Article
Dearnley, B., Jones, M., Dervinis, M., & Okun, M. (2023). Brain state transitions primarily impact the spontaneous rate of slow-firing neurons. Cell Reports, 42(10), Article 113185. https://doi.org/10.1016/j.celrep.2023.113185

The spontaneous firing of neurons is modulated by brain state. Here, we examine how such modulation impacts the overall distribution of firing rates in neuronal populations of neocortical, hippocampal, and thalamic areas across natural and pharmacolo... Read More about Brain state transitions primarily impact the spontaneous rate of slow-firing neurons.

Logarithmically scaled, gamma distributed neuronal spiking (2022)
Journal Article
Levenstein, D., & Okun, M. (2023). Logarithmically scaled, gamma distributed neuronal spiking. Journal of Physiology, 601(15), 3055-3069. https://doi.org/10.1113/jp282758

Naturally log-scaled quantities abound in the nervous system. Distributions of these quantities have non-intuitive properties, which have implications for data analysis and the understanding of neural circuits. Here, we review the log-scaled statisti... Read More about Logarithmically scaled, gamma distributed neuronal spiking.

Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings (2021)
Journal Article
Steinmetz, N. A., Aydin, C., Lebedeva, A., Okun, M., Pachitariu, M., Bauza, M., Beau, M., Bhagat, J., Böhm, C., Broux, M., Chen, S., Colonell, J., Gardner, R. J., Karsh, B., Kloosterman, F., Kostadinov, D., Mora-Lopez, C., O’Callaghan, J., Park, J., Putzeys, J., …Harris, T. D. (2021). Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings. Science, 372(6539), Article eabf4588. https://doi.org/10.1126/science.abf4588

Measuring the dynamics of neural processing across time scales requires following the spiking of thousands of individual neurons over milliseconds and months. To address this need, we introduce the Neuropixels 2.0 probe together with newly designed a... Read More about Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings.

Long Term Recordings with Immobile Silicon Probes in the Mouse Cortex (2016)
Journal Article
Okun, M., Lak, A., Carandini, M., & Harris, K. D. (2016). Long Term Recordings with Immobile Silicon Probes in the Mouse Cortex. PLoS ONE, 11(3), Article e0151180. https://doi.org/10.1371/journal.pone.0151180

A key experimental approach in neuroscience involves measuring neuronal activity in behaving animals with extracellular chronic recordings. Such chronic recordings were initially made with single electrodes and tetrodes, and are now increasingly perf... Read More about Long Term Recordings with Immobile Silicon Probes in the Mouse Cortex.