GYY4137, a hydrogen sulfide donor, protects against endothelial dysfunction in porcine coronary arteries exposed to myeloperoxidase and hypochlorous acid

Harper, Andrew; Chapel, Maike; Hodgson, Grace; Malinowski, Krzysztof; Yates, Imogen; Garle, Michael; Ralevic, Vera

doi:10.1016/j.vph.2023.107199

All Outputs (1)

GYY4137, a hydrogen sulfide donor, protects against endothelial dysfunction in porcine coronary arteries exposed to myeloperoxidase and hypochlorous acid (2023)
Journal Article
Harper, A., Chapel, M., Hodgson, G., Malinowski, K., Yates, I., Garle, M., & Ralevic, V. (2023). GYY4137, a hydrogen sulfide donor, protects against endothelial dysfunction in porcine coronary arteries exposed to myeloperoxidase and hypochlorous acid. Vascular Pharmacology, 152, Article 107199. https://doi.org/10.1016/j.vph.2023.107199

Background and aims:
Myeloperoxidase (MPO) and its principal reaction product hypochlorous acid (HOCl) are part of the innate immune response but are also associated with endothelial dysfunction, thought to involve a reduction in nitric oxide (NO)... Read More about GYY4137, a hydrogen sulfide donor, protects against endothelial dysfunction in porcine coronary arteries exposed to myeloperoxidase and hypochlorous acid.