Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging

Harston, George W. J.; Tee, Yee Kai; Blockley, Nicholas; Okell, Thomas W.; Thandeswaran, Sivarajan; Shaya, Gabriel; Sheerin, Fintan; Cellerini, Martino; Payne, Stephen; Jezzard, Peter; Chappell, Michael; Kennedy, James

doi:10.1093/brain/awu374

All Outputs (48)

Quantitative blood flow measurement in rat brain with multiphase arterial spin labelling magnetic resonance imaging (2018)
Journal Article
Larkin, J. R., Simard, M. A., Khrapitchev, A. A., Meakin, J. A., Okell, T. W., Craig, M., Ray, K. J., Jezzard, P., Chappell, M. A., & Sibson, N. R. (2019). Quantitative blood flow measurement in rat brain with multiphase arterial spin labelling magnetic resonance imaging. Journal of Cerebral Blood Flow and Metabolism, 39(8), 1557-1569. https://doi.org/10.1177/0271678x18756218

A DCE-MRI Driven 3-D Reaction-Diffusion Model of Solid Tumor Growth (2017)
Journal Article
Roque, T., Risser, L., Kersemans, V., Smart, S., Allen, D., Kinchesh, P., Gilchrist, S., Gomes, A. L., Schnabel, J. A., & Chappell, M. A. (2018). A DCE-MRI Driven 3-D Reaction-Diffusion Model of Solid Tumor Growth. IEEE Transactions on Medical Imaging, 37(3), 724-732. https://doi.org/10.1109/tmi.2017.2779811

Predicting tumor growth and its response to therapy remains a major challenge in cancer research and strongly relies on tumor growth models. In this paper, we introduce, calibrate, and verify a novel image-driven reaction-diffusion model of avascular... Read More about A DCE-MRI Driven 3-D Reaction-Diffusion Model of Solid Tumor Growth.

The relationship between blood flow impairment and oxygen depletion in acute ischemic stroke imaged with magnetic resonance imaging (2017)
Journal Article
Seiler, A., Blockley, N. P., Deichmann, R., Nöth, U., Singer, O. C., Chappell, M. A., Klein, J. C., & Wagner, M. (2017). The relationship between blood flow impairment and oxygen depletion in acute ischemic stroke imaged with magnetic resonance imaging. Journal of Cerebral Blood Flow and Metabolism, https://doi.org/10.1177/0271678x17732448

A systematic study of the sensitivity of partial volume correction methods for the quantification of perfusion from pseudo-continuous arterial spin labeling MRI (2017)
Journal Article
Zhao, M. Y., Mezue, M., Segerdahl, A. R., Okell, T. W., Tracey, I., Xiao, Y., & Chappell, M. A. (2017). A systematic study of the sensitivity of partial volume correction methods for the quantification of perfusion from pseudo-continuous arterial spin labeling MRI. NeuroImage, 162, 384-397. https://doi.org/10.1016/j.neuroimage.2017.08.072

Arterial spin labeling (ASL) MRI is a non-invasive technique for the quantification of cerebral perfusion, and pseudo-continuous arterial spin labeling (PCASL) has been recommended as the standard implementation by a recent consensus of the community... Read More about A systematic study of the sensitivity of partial volume correction methods for the quantification of perfusion from pseudo-continuous arterial spin labeling MRI.

Relationship between haemodynamic impairment and collateral blood flow in carotid artery disease (2017)
Journal Article
Hartkamp, N. S., Petersen, E. T., Chappell, M. A., Okell, T. W., Uyttenboogaart, M., Zeebregts, C. J., & Bokkers, R. P. (2018). Relationship between haemodynamic impairment and collateral blood flow in carotid artery disease. Journal of Cerebral Blood Flow and Metabolism, 38(11), 2021-2032. https://doi.org/10.1177/0271678x17724027

Collateral blood flow plays a pivotal role in steno-occlusive internal carotid artery (ICA) disease to prevent irreversible ischaemic damage. Our aim was to investigate the effect of carotid artery disease upon cerebral perfusion and cerebrovascular... Read More about Relationship between haemodynamic impairment and collateral blood flow in carotid artery disease.

Feasibility of Flat Panel Detector CT in Perfusion Assessment of Brain Arteriovenous Malformations: Initial Clinical Experience (2017)
Journal Article
Garcia, M., Okell, T., Gloor, M., Chappell, M., Jezzard, P., Bieri, O., & Byrne, J. (2017). Feasibility of Flat Panel Detector CT in Perfusion Assessment of Brain Arteriovenous Malformations: Initial Clinical Experience. American Journal of Neuroradiology, 38(4), 735-739. https://doi.org/10.3174/ajnr.a5091

The different results from flat panel detector CT in various pathologies have provoked some discussion. Our aim was to assess the role of flat panel detector CT in brain arteriovenous malformations, which has not yet been assessed. Five patients with... Read More about Feasibility of Flat Panel Detector CT in Perfusion Assessment of Brain Arteriovenous Malformations: Initial Clinical Experience.

Quantification of Serial Cerebral Blood Flow in Acute Stroke Using Arterial Spin Labeling (2016)
Journal Article
Harston, G. W., Okell, T. W., Sheerin, F., Schulz, U., Mathieson, P., Reckless, I., Shah, K., Ford, G. A., Chappell, M. A., Jezzard, P., & Kennedy, J. (2017). Quantification of Serial Cerebral Blood Flow in Acute Stroke Using Arterial Spin Labeling. Stroke, 48(1), 123-130. https://doi.org/10.1161/strokeaha.116.014707

Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging (2014)
Journal Article
Harston, G. W. J., Tee, Y. K., Blockley, N., Okell, T. W., Thandeswaran, S., Shaya, G., Sheerin, F., Cellerini, M., Payne, S., Jezzard, P., Chappell, M., & Kennedy, J. (2015). Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging. Brain, 138(1), 36-42. https://doi.org/10.1093/brain/awu374

© 2014 The Author. The original concept of the ischaemic penumbra suggested imaging of regional cerebral blood flow and metabolism would be required to identify tissue that may benefit from intervention. Amide proton transfer magnetic resonance imagi... Read More about Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging.