All Outputs (24)

Corticotrophin releasing factor increases ascending colon volume after a fructose test meal in healthy humans: a randomised control trial (2016)
Journal Article
Murray, K., Lam, C., Rehman, S., Marciani, L., Costigan, C., Hoad, C., Lingaya, M., Banwait, R., Bawden, S., Gowland, P. A., & Spiller, R. C. (2016). Corticotrophin releasing factor increases ascending colon volume after a fructose test meal in healthy humans: a randomised control trial. American Journal of Clinical Nutrition, 103(5), https://doi.org/10.3945/ajcn.115.125047

Background: Poorly absorbed, fermentable carbohydrates can provoke irritable bowel syndrome (IBS) symptoms by escaping absorption in the small bowel and being rapidly fermented in the colon in some susceptible subjects. IBS patients are often anxious... Read More about Corticotrophin releasing factor increases ascending colon volume after a fructose test meal in healthy humans: a randomised control trial.

A mechanistic multi-centre, parallel group, randomised placebo controlled trial of Mesalazine for treatment of irritable bowel syndrome with diarrhoea (IBS-D) (2015)
Journal Article
Lam, C., Tan, W., Leighton, M., Hastings, M., Lingaya, M., Falcone, Y., Zhou, X., Xu, L., Whorwell, P., Walls, A., Zaitoun, A. M., Montgomery, A., & Spiller, R. C. (2015). A mechanistic multi-centre, parallel group, randomised placebo controlled trial of Mesalazine for treatment of irritable bowel syndrome with diarrhoea (IBS-D). Gut, 65(1), https://doi.org/10.1136/gutjnl-2015-309122

Introduction: Immune activation has been reported in the mucosa of irritable bowel syndrome patients with diarrhoea (IBS-D) and some small studies have suggested that Mesalazine may reduce symptoms. We performed a double blind, randomised placebo con... Read More about A mechanistic multi-centre, parallel group, randomised placebo controlled trial of Mesalazine for treatment of irritable bowel syndrome with diarrhoea (IBS-D).

Effect of experimental stress on the small bowel and colon in healthy humans (2015)
Journal Article
Pritchard, S. E., Garsed, K. C., Hoad, C. L., Lingaya, M., Banwait, R., Thongborisute, W., Roberts, E., Costigan, C., Marciani, L., Gowland, P. A., & Spiller, R. C. (2015). Effect of experimental stress on the small bowel and colon in healthy humans. Neurogastroenterology and Motility, 27(4), 542-549. https://doi.org/10.1111/nmo.12529

Characterisation of faecal protease activity in irritable bowel syndrome with diarrhoea: origin and effect of gut transit (2013)
Journal Article
Tooth, D., Garsed, K., Singh, G., Marciani, L., Lam, C., Fordham, I., Fields, A., Banwait, R., Lingaya, M., Layfield, R., Hastings, M., Whorwell, P., & Spiller, R. C. (2014). Characterisation of faecal protease activity in irritable bowel syndrome with diarrhoea: origin and effect of gut transit. Gut, 63(5), 753-760. https://doi.org/10.1136/gutjnl-2012-304042