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All Outputs (93)

A Medical Student Curriculum on Functional Medical Disorders (2025)
Journal Article
Butt, M., Scotto, D., Gilmartin, C., Dhali, A., Gonem, S., Singhal, S., Monaghan, T., Frain, J., & Corsetti, M. (2025). A Medical Student Curriculum on Functional Medical Disorders. Clinical Teacher, 22(4), Article e70117. https://doi.org/10.1111/tct.70117

Background

Functional medical disorders (FMDs) refer to persistent physical symptoms that result in impairment or disability, which cannot be diagnosed using routine medical testing. Negative perceptions towards FMDs exist among a variety of heal... Read More about A Medical Student Curriculum on Functional Medical Disorders.

Effect of propinox and pinaverium bromide on ex vivo colonic motor patterns and their synergistic effect with hyoscine butyl bromide (2025)
Journal Article
Traserra, S., Alcalá-González, L. G., Barber, C., Landolfi, S., Malagelada, C., Lange, R., Appelqvist, T., Corsetti, M., & Jimenez, M. (2025). Effect of propinox and pinaverium bromide on ex vivo colonic motor patterns and their synergistic effect with hyoscine butyl bromide. Frontiers in Pharmacology, 16, Article 1491123. https://doi.org/10.3389/fphar.2025.1491123

Background:

Antispasmodic agents are used to treat abdominal pain. The mode of action of pinaverium bromide and propinox in the colonic tissue has never been characterized. This study aimed to explore whether HBB can complement the antispasmodic... Read More about Effect of propinox and pinaverium bromide on ex vivo colonic motor patterns and their synergistic effect with hyoscine butyl bromide.

Could the Therapeutic Effect of Physical Activity on Irritable Bowel Syndrome Be Mediated Through Changes to the Gut Microbiome? A Narrative and Hypothesis Generating Review (2025)
Journal Article
Lindsell, H. B., Williams, N. C., Magistro, D., Corsetti, M., Walton, G. E., & Hunter, K. A. (2025). Could the Therapeutic Effect of Physical Activity on Irritable Bowel Syndrome Be Mediated Through Changes to the Gut Microbiome? A Narrative and Hypothesis Generating Review. Neurogastroenterology and Motility, Article e70004. https://doi.org/10.1111/nmo.70004

Background: Irritable bowel syndrome (IBS) is one of the most prevalent gastrointestinal (GI) disorders worldwide. Defined as a disorder of gut-brain interaction, its pathophysiology is still not completely clear. Consequently, current treatments pri... Read More about Could the Therapeutic Effect of Physical Activity on Irritable Bowel Syndrome Be Mediated Through Changes to the Gut Microbiome? A Narrative and Hypothesis Generating Review.

Clinical Characteristics and Outcomes of Patients With Rome IV Functional Dyspepsia Who Consume Opioids: A Real‐World Study (2025)
Journal Article
Butt, M. F., Isherwood, G., Lewis‐Lawson, T., Sbarigia, C., Lambiase, C., Aburumman, R. N. M., Dhali, A., Bush, D., Card, T., & Corsetti, M. (2025). Clinical Characteristics and Outcomes of Patients With Rome IV Functional Dyspepsia Who Consume Opioids: A Real‐World Study. Neurogastroenterology and Motility, 37(7), Article e15019. https://doi.org/10.1111/nmo.15019

Introduction
The prevalence of opioid use and its impact on healthcare outcomes among patients with Rome IV functional dyspepsia (FD) has not been reported in real-world clinical practice in the United Kingdom (UK). The primary aim of this study was... Read More about Clinical Characteristics and Outcomes of Patients With Rome IV Functional Dyspepsia Who Consume Opioids: A Real‐World Study.

Impact of Opioid and Cannabis Use on Low-Dose Amitriptyline Efficacy in Cyclical Vomiting Syndrome: A Real-World Study in the United Kingdom (2025)
Journal Article
Butt, M. F., Cefalo, F., Sbarigia, C., Dhali, A., & Corsetti, M. (2025). Impact of Opioid and Cannabis Use on Low-Dose Amitriptyline Efficacy in Cyclical Vomiting Syndrome: A Real-World Study in the United Kingdom. Neurogastroenterology and Motility, Article e70007. https://doi.org/10.1111/nmo.70007

Background: Central neuromodulators, specifically tricyclic antidepressants (TCAs), are prescribed as prophylactic treatment for cyclical vomiting syndrome (CVS). It is unclear whether opioids and/or cannabis affect the treatment response to neuromod... Read More about Impact of Opioid and Cannabis Use on Low-Dose Amitriptyline Efficacy in Cyclical Vomiting Syndrome: A Real-World Study in the United Kingdom.

Gastroenterology Training and Career in Women: Challenges and Opportunities (2025)
Journal Article
Manthopoulou, E., Catalan‐Serra, I., Corsetti, M., Nowak, A., Perugorria, M. J., Simsek, C., & Ciacci, C. (2025). Gastroenterology Training and Career in Women: Challenges and Opportunities. United European Gastroenterology Journal, 13(4), 650-655. https://doi.org/10.1002/ueg2.12764

This review highlights gender gaps in training, career, and work-life balance in gastroenterology. Stereotypes and biases toward women’s abilities and commitment to their careers can influence evaluations, advancement in gastroenterology training, an... Read More about Gastroenterology Training and Career in Women: Challenges and Opportunities.

Oral hyoscine butylbromide exerts spasmolytic effects in both gastrointestinal and urogenital tissues in rats (2025)
Journal Article
Traserra, S., Appelqvist, T., Lange, R., Corsetti, M., & Jimenez, M. (2025). Oral hyoscine butylbromide exerts spasmolytic effects in both gastrointestinal and urogenital tissues in rats. British Journal of Pharmacology, 182(11), 2487-2502. https://doi.org/10.1111/bph.17474

Background and Purpose
Hyoscine butylbromide (HBB) has a low oral (PO) bioavailability. Further, limited data on its activity on non-gastrointestinal (GI) smooth muscle spasms after oral dosing are available, causing its effects beyond the GI tract... Read More about Oral hyoscine butylbromide exerts spasmolytic effects in both gastrointestinal and urogenital tissues in rats.

Oral Hyoscine butylbromide exerts spasmolytic effects both in gastrointestinal and urogenital tissues in rats (2025)
Journal Article
Traserra, S., Appelqvist, T., Lange, R., Corsetti, M., & Jimenez, M. (2025). Oral Hyoscine butylbromide exerts spasmolytic effects both in gastrointestinal and urogenital tissues in rats. British Journal of Pharmacology, 182(11), 2487-2502. https://doi.org/10.1111/bph.17474

Background and Purpose: Hyoscine butylbromide (HBB) has a low oral (PO) bioavailability. Further, limited data on its activity on non-gastrointestinal (GI) smooth muscle spasms after oral dosing are available, meaning its effect outside the GI tract... Read More about Oral Hyoscine butylbromide exerts spasmolytic effects both in gastrointestinal and urogenital tissues in rats.

European Guideline on Chronic Nausea and Vomiting—A UEG and ESNM Consensus for Clinical Management (2025)
Journal Article
Malagelada, C., Keller, J., Sifrim, D., Serra, J., Tack, J., Mulak, A., Stengel, A., Aguilar, A., Drewes, A. M., Josefsson, A., Bonaz, B., Dumitrascu, D., Keszthelyi, D., Barba, E., Carbone, F., Zerbib, F., Marchegiani, G., Hauser, G., Gourcerol, G., Tornblom, H., …Surdea-Blaga, T. (2025). European Guideline on Chronic Nausea and Vomiting—A UEG and ESNM Consensus for Clinical Management. United European Gastroenterology Journal, 13(3), 427-471. https://doi.org/10.1002/ueg2.12711

Introduction: Chronic nausea and vomiting are symptoms of a wide range of gastrointestinal and non-gastrointestinal conditions. Diagnosis can be challenging and requires a systematic and well-structured approach. If the initial investigation for stru... Read More about European Guideline on Chronic Nausea and Vomiting—A UEG and ESNM Consensus for Clinical Management.

Mode of Action of Psyllium in Reducing Gas Production from Inulin and its Interaction with Colonic Microbiota: A 24-hour, Randomized, Placebo-Controlled Trial in Healthy Human Volunteers (2024)
Journal Article
Alhasani, A., Modasia, A., Anodiyil, M., Corsetti, M., Aliyu, A., Crooks, C., MARCIANI, L., Reid, J., Yakubov, G., Avery, A., Harris, H., Warren, F., & Spiller, R. (2025). Mode of Action of Psyllium in Reducing Gas Production from Inulin and its Interaction with Colonic Microbiota: A 24-hour, Randomized, Placebo-Controlled Trial in Healthy Human Volunteers. Journal of Nutrition, 155(3), 839-848. https://doi.org/10.1016/j.tjnut.2024.12.017

Background
Recent studies show that the increase in breath hydrogen (BH2) and symptoms after ingestion of inulin are reduced by coadministering psyllium (PI).

Objectives
To determine if slowing delivery of inulin to the colon by administering it... Read More about Mode of Action of Psyllium in Reducing Gas Production from Inulin and its Interaction with Colonic Microbiota: A 24-hour, Randomized, Placebo-Controlled Trial in Healthy Human Volunteers.

Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation (2024)
Journal Article
Aliyu, A., Dellschaft, N., Hoad, C., Williams, H., Gaudoin, E., Sulaiman, S., Crooks, C., Gowland, P., Alexia, A., Lange, R., Bois de Fer, B., Corsetti, M., Marciani, L., & Spiller, R. (2025). Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation. Clinical Pharmacology and Therapeutics, 177(5), 1284-1291. https://doi.org/10.1002/cpt.3532

Bisacodyl is a widely used laxative that stimulates both motility and secretion. Our aim was to exploit the unique capabilities of MRI to define bisacodyl's mode of action. Two placebo-controlled cross-over trials were performed, one using a single d... Read More about Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation.

Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation (2024)
Journal Article
Aliyu, A., Dellschaft, N., Hoad, C., Williams, H., Gaudoin, E., Sulaiman, S., Crooks, C., Gowland, P., Aran, A., Lange, R., Bois De Fer, B., Corsetti, M., Marciani, L., & Spiller, R. (2025). Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation. Clinical Pharmacology and Therapeutics, 117(5), 1284-1291. https://doi.org/10.1002/cpt.3532

Bisacodyl is a widely used laxative that stimulates both motility and secretion. Our aim was to exploit the unique capabilities of MRI to define bisacodyl's mode of action. Two placebo-controlled cross-over trials were performed, one using a single d... Read More about Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation.

Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study (2024)
Journal Article
Wilkinson-Smith, V., Scott, M., Menys, A., Wiklendt, L., Marciani, L., Atkinson, D., Sansone, S., Zdanaviciene, A., Coupland, C., Knowles, C. H., Dinning, P., Taylor, S. A., Gowland, P., Hoad, C. L., Corsetti, M., & Spiller, R. C. (2024). Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study. Gut, 74(1), 35-44. https://doi.org/10.1136/gutjnl-2024-332755

Background: Colonic motility in constipation can be assessed non-invasively using MRI.

Objective: To compare MRI with high-resolution colonic manometry (HRCM) for predicting treatment response.

Design: Part 1: 44 healthy volunteers (HVs), 43 pa... Read More about Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study.

Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study (2024)
Journal Article
Wilkinson-Smith, V., Scott, M., Menys, A., Wiklendt, L., MARCIANI, L., Atkinson, D., Sansone, S., Zdanavciene, A., Coupland, C., Knowles, C., Dinning, P., Taylor, S., Gowland, P., Hoad, C., Corsetti, M., & Spiller, R. (2025). Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study. Gut, 74(1), 35-44. https://doi.org/10.1136/gutjnl-2024-332755

Background
Colonic motility in constipation can be assessed non-invasively using MRI.

Objective
To compare MRI with high resolution colonic manometry (HRCM) for predicting treatment response.

Design
Part 1: 44 healthy volunteers (HV), 43... Read More about Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study.

Functional Variation in Human CAZyme Genes in Relation to the Efficacy of a Carbohydrate-Restricted Diet in IBS Patients (2024)
Journal Article
Zamfir-Taranu, A., Löscher, B.-S., Carbone, F., Hoter, A., Esteban Blanco, C., Bozzarelli, I., Torices, L., Routhiaux, K., Van den Houte, K., Bonfiglio, F., Mayr, G., Corsetti, M., Naim, H. Y., Franke, A., Tack, J., & D’Amato, M. (2025). Functional Variation in Human CAZyme Genes in Relation to the Efficacy of a Carbohydrate-Restricted Diet in IBS Patients. Clinical Gastroenterology and Hepatology, 23(7), 1228-1237.e10. https://doi.org/10.1016/j.cgh.2024.09.004

Background & Aims
Limiting the dietary intake of certain carbohydrates has therapeutic effects in some but not all irritable bowel syndrome (IBS) patients. We investigated genetic variation in human Carbohydrate-Active enZYmes (hCAZymes) genes in re... Read More about Functional Variation in Human CAZyme Genes in Relation to the Efficacy of a Carbohydrate-Restricted Diet in IBS Patients.

Pediatric to adult transition care in neurogastroenterology and motility: A position paper from the American Neurogastroenterology and Motility Society and European Society of Neurogastroenterology and Motility (2024)
Journal Article
Butt, M. F., Groen, J., Corsetti, M., Jonker, C. A., Burton‐Murray, H., Carrington, E. V., Chang, L., Di Lorenzo, C., Ellis, J., Escher, J. C., Gorter, R. R., Jewell, S., Karrento, K., Koster, E. C., Nurko, S., Rosen, R., van Tilburg, M. A., Zarate-Lopez, N., & Benninga, M. A. (2024). Pediatric to adult transition care in neurogastroenterology and motility: A position paper from the American Neurogastroenterology and Motility Society and European Society of Neurogastroenterology and Motility. Neurogastroenterology and Motility, 36(10), Article e14869. https://doi.org/10.1111/nmo.14869

Transition services—programs that support adolescents and young adults (AYAs) as they move from a child‐centered to a more autonomous, adult‐orientated healthcare system—have been associated with improved short‐ and long‐term healthcare outcomes. Unf... Read More about Pediatric to adult transition care in neurogastroenterology and motility: A position paper from the American Neurogastroenterology and Motility Society and European Society of Neurogastroenterology and Motility.

Evaluation of the mechanism of action of paracetamol, drotaverine, and peppermint oil and their effects in combination with hyoscine butylbromide on colonic motility: Human ex-vivo study (2024)
Journal Article
Traserra, S., Barber, C., Gerardo Alcalá-González, L., Landolfi, S., Lange, R., Malagelada, C., Corsetti, M., & Jimenez, M. (2024). Evaluation of the mechanism of action of paracetamol, drotaverine, and peppermint oil and their effects in combination with hyoscine butylbromide on colonic motility: Human ex-vivo study. Frontiers in Pharmacology, 15, Article 1384070. https://doi.org/10.3389/fphar.2024.1384070

Introduction: Drotaverine, paracetamol, and peppermint oil are often prescribed for the treatment of gastrointestinal spasm and pain. This study aimed to evaluate the effect of these drugs alone and combined with the well-known antispasmodic hyoscine... Read More about Evaluation of the mechanism of action of paracetamol, drotaverine, and peppermint oil and their effects in combination with hyoscine butylbromide on colonic motility: Human ex-vivo study.

Coffee, Alcohol, and Artificial Sweeteners Have Temporal Associations with Gastrointestinal Symptoms (2024)
Journal Article
Clevers, E., Launders, D., Helme, D., Nybacka, S., Störsrud, S., Corsetti, M., Van Oudenhove, L., Simrén, M., & Tack, J. (2024). Coffee, Alcohol, and Artificial Sweeteners Have Temporal Associations with Gastrointestinal Symptoms. Digestive Diseases and Sciences, 69, 2522-2529. https://doi.org/10.1007/s10620-024-08457-y

Background
Various dietary strategies for managing irritable bowel syndrome (IBS) target mechanisms such as brain–gut interactions, osmotic actions, microbial gas production, and local immune activity. These pathophysiological mechanisms are diverse... Read More about Coffee, Alcohol, and Artificial Sweeteners Have Temporal Associations with Gastrointestinal Symptoms.