All Outputs (8)

Effect of propinox and pinaverium bromide on ex vivo colonic motor patterns and their synergistic effect with hyoscine butyl bromide (2025)
Journal Article
Traserra, S., Alcalá-González, L. G., Barber, C., Landolfi, S., Malagelada, C., Lange, R., Appelqvist, T., Corsetti, M., & Jimenez, M. (2025). Effect of propinox and pinaverium bromide on ex vivo colonic motor patterns and their synergistic effect with hyoscine butyl bromide. Frontiers in Pharmacology, 16, Article 1491123. https://doi.org/10.3389/fphar.2025.1491123

Background:

Antispasmodic agents are used to treat abdominal pain. The mode of action of pinaverium bromide and propinox in the colonic tissue has never been characterized. This study aimed to explore whether HBB can complement the antispasmodic... Read More about Effect of propinox and pinaverium bromide on ex vivo colonic motor patterns and their synergistic effect with hyoscine butyl bromide.

Could the Therapeutic Effect of Physical Activity on Irritable Bowel Syndrome Be Mediated Through Changes to the Gut Microbiome? A Narrative and Hypothesis Generating Review (2025)
Journal Article
Lindsell, H. B., Williams, N. C., Magistro, D., Corsetti, M., Walton, G. E., & Hunter, K. A. (2025). Could the Therapeutic Effect of Physical Activity on Irritable Bowel Syndrome Be Mediated Through Changes to the Gut Microbiome? A Narrative and Hypothesis Generating Review. Neurogastroenterology and Motility, Article e70004. https://doi.org/10.1111/nmo.70004

Background: Irritable bowel syndrome (IBS) is one of the most prevalent gastrointestinal (GI) disorders worldwide. Defined as a disorder of gut-brain interaction, its pathophysiology is still not completely clear. Consequently, current treatments pri... Read More about Could the Therapeutic Effect of Physical Activity on Irritable Bowel Syndrome Be Mediated Through Changes to the Gut Microbiome? A Narrative and Hypothesis Generating Review.

Impact of Opioid and Cannabis Use on Low-Dose Amitriptyline Efficacy in Cyclical Vomiting Syndrome: A Real-World Study in the United Kingdom (2025)
Journal Article
Butt, M. F., Cefalo, F., Sbarigia, C., Dhali, A., & Corsetti, M. (2025). Impact of Opioid and Cannabis Use on Low-Dose Amitriptyline Efficacy in Cyclical Vomiting Syndrome: A Real-World Study in the United Kingdom. Neurogastroenterology and Motility, Article e70007. https://doi.org/10.1111/nmo.70007

Background: Central neuromodulators, specifically tricyclic antidepressants (TCAs), are prescribed as prophylactic treatment for cyclical vomiting syndrome (CVS). It is unclear whether opioids and/or cannabis affect the treatment response to neuromod... Read More about Impact of Opioid and Cannabis Use on Low-Dose Amitriptyline Efficacy in Cyclical Vomiting Syndrome: A Real-World Study in the United Kingdom.

Clinical Characteristics and Outcomes of Patients With Rome IV Functional Dyspepsia Who Consume Opioids: A Real‐World Study (2025)
Journal Article
Butt, M. F., Isherwood, G., Lewis‐Lawson, T., Sbarigia, C., Lambiase, C., Aburumman, R. N. M., Dhali, A., Bush, D., Card, T., & Corsetti, M. (2025). Clinical Characteristics and Outcomes of Patients With Rome IV Functional Dyspepsia Who Consume Opioids: A Real‐World Study. Neurogastroenterology and Motility, 37(7), Article e15019. https://doi.org/10.1111/nmo.15019

Introduction
The prevalence of opioid use and its impact on healthcare outcomes among patients with Rome IV functional dyspepsia (FD) has not been reported in real-world clinical practice in the United Kingdom (UK). The primary aim of this study was... Read More about Clinical Characteristics and Outcomes of Patients With Rome IV Functional Dyspepsia Who Consume Opioids: A Real‐World Study.

Gastroenterology Training and Career in Women: Challenges and Opportunities (2025)
Journal Article
Manthopoulou, E., Catalan‐Serra, I., Corsetti, M., Nowak, A., Perugorria, M. J., Simsek, C., & Ciacci, C. (2025). Gastroenterology Training and Career in Women: Challenges and Opportunities. United European Gastroenterology Journal, 13(4), 650-655. https://doi.org/10.1002/ueg2.12764

This review highlights gender gaps in training, career, and work-life balance in gastroenterology. Stereotypes and biases toward women’s abilities and commitment to their careers can influence evaluations, advancement in gastroenterology training, an... Read More about Gastroenterology Training and Career in Women: Challenges and Opportunities.

Oral Hyoscine butylbromide exerts spasmolytic effects both in gastrointestinal and urogenital tissues in rats (2025)
Journal Article
Traserra, S., Appelqvist, T., Lange, R., Corsetti, M., & Jimenez, M. (2025). Oral Hyoscine butylbromide exerts spasmolytic effects both in gastrointestinal and urogenital tissues in rats. British Journal of Pharmacology, 182(11), 2487-2502. https://doi.org/10.1111/bph.17474

Background and Purpose: Hyoscine butylbromide (HBB) has a low oral (PO) bioavailability. Further, limited data on its activity on non-gastrointestinal (GI) smooth muscle spasms after oral dosing are available, meaning its effect outside the GI tract... Read More about Oral Hyoscine butylbromide exerts spasmolytic effects both in gastrointestinal and urogenital tissues in rats.

Oral hyoscine butylbromide exerts spasmolytic effects in both gastrointestinal and urogenital tissues in rats (2025)
Journal Article
Traserra, S., Appelqvist, T., Lange, R., Corsetti, M., & Jimenez, M. (2025). Oral hyoscine butylbromide exerts spasmolytic effects in both gastrointestinal and urogenital tissues in rats. British Journal of Pharmacology, 182(11), 2487-2502. https://doi.org/10.1111/bph.17474

Background and Purpose
Hyoscine butylbromide (HBB) has a low oral (PO) bioavailability. Further, limited data on its activity on non-gastrointestinal (GI) smooth muscle spasms after oral dosing are available, causing its effects beyond the GI tract... Read More about Oral hyoscine butylbromide exerts spasmolytic effects in both gastrointestinal and urogenital tissues in rats.

European Guideline on Chronic Nausea and Vomiting—A UEG and ESNM Consensus for Clinical Management (2025)
Journal Article
Malagelada, C., Keller, J., Sifrim, D., Serra, J., Tack, J., Mulak, A., Stengel, A., Aguilar, A., Drewes, A. M., Josefsson, A., Bonaz, B., Dumitrascu, D., Keszthelyi, D., Barba, E., Carbone, F., Zerbib, F., Marchegiani, G., Hauser, G., Gourcerol, G., Tornblom, H., …Surdea-Blaga, T. (2025). European Guideline on Chronic Nausea and Vomiting—A UEG and ESNM Consensus for Clinical Management. United European Gastroenterology Journal, 13(3), 427-471. https://doi.org/10.1002/ueg2.12711

Introduction: Chronic nausea and vomiting are symptoms of a wide range of gastrointestinal and non-gastrointestinal conditions. Diagnosis can be challenging and requires a systematic and well-structured approach. If the initial investigation for stru... Read More about European Guideline on Chronic Nausea and Vomiting—A UEG and ESNM Consensus for Clinical Management.