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European Guideline on Chronic Nausea and Vomiting—A UEG and ESNM Consensus for Clinical Management (2025)
Journal Article
Malagelada, C., Keller, J., Sifrim, D., Serra, J., Tack, J., Mulak, A., Stengel, A., Aguilar, A., Drewes, A. M., Josefsson, A., Bonaz, B., Dumitrascu, D., Keszthelyi, D., Barba, E., Carbone, F., Zerbib, F., Marchegiani, G., Hauser, G., Gourcerol, G., Tornblom, H., …Surdea-Blaga, T. (2025). European Guideline on Chronic Nausea and Vomiting—A UEG and ESNM Consensus for Clinical Management. United European Gastroenterology Journal, https://doi.org/10.1002/ueg2.12711

Introduction: Chronic nausea and vomiting are symptoms of a wide range of gastrointestinal and non-gastrointestinal conditions. Diagnosis can be challenging and requires a systematic and well-structured approach. If the initial investigation for stru... Read More about European Guideline on Chronic Nausea and Vomiting—A UEG and ESNM Consensus for Clinical Management.

Mode of Action of Psyllium in Reducing Gas Production from Inulin and its Interaction with Colonic Microbiota: A 24 hours, Randomised, Placebo-Controlled Trial in Healthy Human Volunteers (2024)
Journal Article
Alhasani, A., Modasia, A., Anodiyil, M., Corsetti, M., Aliyu, A., Crooks, C., MARCIANI, L., Reid, J., Yakubov, G., Avery, A., Harris, H., Warren, F., & Spiller, R. (2024). Mode of Action of Psyllium in Reducing Gas Production from Inulin and its Interaction with Colonic Microbiota: A 24 hours, Randomised, Placebo-Controlled Trial in Healthy Human Volunteers. Journal of Nutrition, https://doi.org/10.1016/j.tjnut.2024.12.017

Background: Recent studies show that the increase in breath hydrogen (BH2) and symptoms after ingestion of inulin is reduced by co-administering psyllium.

Objectives: To determine if slowing delivery of inulin to the colon by administering it in... Read More about Mode of Action of Psyllium in Reducing Gas Production from Inulin and its Interaction with Colonic Microbiota: A 24 hours, Randomised, Placebo-Controlled Trial in Healthy Human Volunteers.

Oral Hyoscine butylbromide exerts spasmolytic effects both in gastrointestinal and urogenital tissues (2024)
Journal Article
Traserra, S., Appelqvist, T., Lange, R., Corsetti, M., & Jimenez, M. (in press). Oral Hyoscine butylbromide exerts spasmolytic effects both in gastrointestinal and urogenital tissues. British Journal of Pharmacology,

Background and Purpose: Hyoscine butylbromide (HBB) has a low oral (PO) bioavailability. Further, limited data on its activity on non-gastrointestinal (GI) smooth muscle spasms after oral dosing are available, meaning its effect outside the GI tract... Read More about Oral Hyoscine butylbromide exerts spasmolytic effects both in gastrointestinal and urogenital tissues.

Oral Hyoscine butylbromide exerts spasmolytic effects both in gastrointestinal and urogenital tissues (2024)
Journal Article
Traserra, S., Appelqvist, T., Lange, R., Corsetti, M., & Jimenez, M. (in press). Oral Hyoscine butylbromide exerts spasmolytic effects both in gastrointestinal and urogenital tissues. British Journal of Pharmacology, 1-40

Background and Purpose: Hyoscine butylbromide (HBB) has a low oral (PO) bioavailability. Further, limited data on its activity on non-gastrointestinal (GI) smooth muscle spasms after oral dosing are available, meaning its effect outside the GI tract... Read More about Oral Hyoscine butylbromide exerts spasmolytic effects both in gastrointestinal and urogenital tissues.

Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation (2024)
Journal Article
Aliyu, A., Dellschaft, N., Hoad, C., Williams, H., Gaudoin, E., Sulaiman, S., Crooks, C., Gowland, P., Alexia, A., Lange, R., Bois de Fer, B., Corsetti, M., Marciani, L., & Spiller, R. (2024). Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation. Clinical Pharmacology and Therapeutics, https://doi.org/10.1002/cpt.3532

Bisacodyl is a widely used laxative that stimulates both motility and secretion. Our aim was to exploit the unique capabilities of MRI to define bisacodyl's mode of action. Two placebo-controlled cross-over trials were performed, one using a single d... Read More about Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation.

Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation (2024)
Journal Article
Aliyu, A., Dellschaft, N., Hoad, C., Williams, H., Gaudoin, E., Sulaiman, S., Crooks, C., Gowland, P., Aran, A., Lange, R., Bois De Fer, B., Corsetti, M., Marciani, L., & Spiller, R. (2024). Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation. Clinical Pharmacology and Therapeutics, https://doi.org/10.1002/cpt.3532

Bisacodyl is a widely used laxative that stimulates both motility and secretion. Our aim was to exploit the unique capabilities of MRI to define bisacodyl's mode of action. Two placebo-controlled cross-over trials were performed, one using a single d... Read More about Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation.

Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study (2024)
Journal Article
Wilkinson-Smith, V., Scott, M., Menys, A., Wiklendt, L., MARCIANI, L., Atkinson, D., Sansone, S., Zdanavciene, A., Coupland, C., Knowles, C., Dinning, P., Taylor, S., Gowland, P., Hoad, C., Corsetti, M., & Spiller, R. (2025). Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study. Gut, 74(1), 35-44. https://doi.org/10.1136/gutjnl-2024-332755

Background
Colonic motility in constipation can be assessed non-invasively using MRI.

Objective
To compare MRI with high resolution colonic manometry (HRCM) for predicting treatment response.

Design
Part 1: 44 healthy volunteers (HV), 43... Read More about Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study.

Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study (2024)
Journal Article
Wilkinson-Smith, V., Scott, M., Menys, A., Wiklendt, L., Marciani, L., Atkinson, D., Sansone, S., Zdanaviciene, A., Coupland, C., Knowles, C. H., Dinning, P., Taylor, S. A., Gowland, P., Hoad, C. L., Corsetti, M., & Spiller, R. C. (2024). Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study. Gut, 74(1), 35-44. https://doi.org/10.1136/gutjnl-2024-332755

Background: Colonic motility in constipation can be assessed non-invasively using MRI.

Objective: To compare MRI with high-resolution colonic manometry (HRCM) for predicting treatment response.

Design: Part 1: 44 healthy volunteers (HVs), 43 pa... Read More about Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study.

Functional Variation in Human CAZyme Genes in Relation to the Efficacy of a Carbohydrate-Restricted Diet in IBS Patients (2024)
Journal Article
Zamfir-Taranu, A., Löscher, B.-S., Carbone, F., Hoter, A., Esteban Blanco, C., Bozzarelli, I., Torices, L., Routhiaux, K., Van den Houte, K., Bonfiglio, F., Mayr, G., Corsetti, M., Naim, H. Y., Franke, A., Tack, J., & D’Amato, M. (2024). Functional Variation in Human CAZyme Genes in Relation to the Efficacy of a Carbohydrate-Restricted Diet in IBS Patients. Clinical Gastroenterology and Hepatology, https://doi.org/10.1016/j.cgh.2024.09.004

Background & Aims
Limiting the dietary intake of certain carbohydrates has therapeutic effects in some but not all irritable bowel syndrome (IBS) patients. We investigated genetic variation in human Carbohydrate-Active enZYmes (hCAZymes) genes in re... Read More about Functional Variation in Human CAZyme Genes in Relation to the Efficacy of a Carbohydrate-Restricted Diet in IBS Patients.

Pediatric to adult transition care in neurogastroenterology and motility: A position paper from the American Neurogastroenterology and Motility Society and European Society of Neurogastroenterology and Motility (2024)
Journal Article
Butt, M. F., Groen, J., Corsetti, M., Jonker, C. A., Burton‐Murray, H., Carrington, E. V., Chang, L., Di Lorenzo, C., Ellis, J., Escher, J. C., Gorter, R. R., Jewell, S., Karrento, K., Koster, E. C., Nurko, S., Rosen, R., van Tilburg, M. A., Zarate-Lopez, N., & Benninga, M. A. (2024). Pediatric to adult transition care in neurogastroenterology and motility: A position paper from the American Neurogastroenterology and Motility Society and European Society of Neurogastroenterology and Motility. Neurogastroenterology and Motility, 36(10), Article e14869. https://doi.org/10.1111/nmo.14869

Transition services—programs that support adolescents and young adults (AYAs) as they move from a child‐centered to a more autonomous, adult‐orientated healthcare system—have been associated with improved short‐ and long‐term healthcare outcomes. Unf... Read More about Pediatric to adult transition care in neurogastroenterology and motility: A position paper from the American Neurogastroenterology and Motility Society and European Society of Neurogastroenterology and Motility.

Evaluation of the mechanism of action of paracetamol, drotaverine, and peppermint oil and their effects in combination with hyoscine butylbromide on colonic motility: Human ex-vivo study (2024)
Journal Article
Traserra, S., Barber, C., Gerardo Alcalá-González, L., Landolfi, S., Lange, R., Malagelada, C., Corsetti, M., & Jimenez, M. (2024). Evaluation of the mechanism of action of paracetamol, drotaverine, and peppermint oil and their effects in combination with hyoscine butylbromide on colonic motility: Human ex-vivo study. Frontiers in Pharmacology, 15, Article 1384070. https://doi.org/10.3389/fphar.2024.1384070

Introduction: Drotaverine, paracetamol, and peppermint oil are often prescribed for the treatment of gastrointestinal spasm and pain. This study aimed to evaluate the effect of these drugs alone and combined with the well-known antispasmodic hyoscine... Read More about Evaluation of the mechanism of action of paracetamol, drotaverine, and peppermint oil and their effects in combination with hyoscine butylbromide on colonic motility: Human ex-vivo study.

Coffee, Alcohol, and Artificial Sweeteners Have Temporal Associations with Gastrointestinal Symptoms (2024)
Journal Article
Clevers, E., Launders, D., Helme, D., Nybacka, S., Störsrud, S., Corsetti, M., Van Oudenhove, L., Simrén, M., & Tack, J. (2024). Coffee, Alcohol, and Artificial Sweeteners Have Temporal Associations with Gastrointestinal Symptoms. Digestive Diseases and Sciences, 69, 2522-2529. https://doi.org/10.1007/s10620-024-08457-y

Background
Various dietary strategies for managing irritable bowel syndrome (IBS) target mechanisms such as brain–gut interactions, osmotic actions, microbial gas production, and local immune activity. These pathophysiological mechanisms are diverse... Read More about Coffee, Alcohol, and Artificial Sweeteners Have Temporal Associations with Gastrointestinal Symptoms.

New insights into the characterization of the mechanism of action of hyoscine butylbromide in the human colon ex vivo (2024)
Journal Article
Traserra, S., Alcalá-González, L. G., Barber, C., Landolfi, S., Malagelada, C., Lange, R., Forestier, S., Corsetti, M., & Jimenez, M. (2024). New insights into the characterization of the mechanism of action of hyoscine butylbromide in the human colon ex vivo. European Journal of Pharmacology, 972, Article 176550. https://doi.org/10.1016/j.ejphar.2024.176550

Introduction: Hyoscine butylbromide (HBB) is one of the most used antispasmodics in clinical practice. Recent translational consensus has demonstrated a similarity between human colonic motor patterns studied ex vivo and in vivo, suggesting ex vivo c... Read More about New insights into the characterization of the mechanism of action of hyoscine butylbromide in the human colon ex vivo.

Ondansetron for irritable bowel syndrome with diarrhoea: randomised controlled trial (2023)
Journal Article
Gunn, D., Topan, R., Fried, R., Holloway, I., Brindle, R., Hartley, S., Barnard, L., Corsetti, M., Scott, S. M., Farmer, A., Akbar, A., Eugenicos, M., Trudgill, N., Kapur, K., McLaughlin, J., Sanders, D. S., Ramadas, A., Whorwell, P., Houghton, L., Dinning, P. G., …Spiller, R. (2023). Ondansetron for irritable bowel syndrome with diarrhoea: randomised controlled trial. Efficacy and Mechanism Evaluation, 10(9), 1-154. https://doi.org/10.3310/ytfw7874

Background: Irritable bowel syndrome with diarrhoea is characterised by frequent, loose or watery stools with associated urgency, resulting in marked reduction of quality of life. Ondansetron, a 5-hydroxytryptamine-3 receptor antagonist, has been sho... Read More about Ondansetron for irritable bowel syndrome with diarrhoea: randomised controlled trial.

Perceptions, definitions, and therapeutic interventions for occasional constipation: a ROME working group consensus document (2023)
Journal Article
Brenner, D. M., Corsetti, M., Drossman, D., Tack, J., & Wald, A. (2024). Perceptions, definitions, and therapeutic interventions for occasional constipation: a ROME working group consensus document. Clinical Gastroenterology and Hepatology, 22(2), 397-412. https://doi.org/10.1016/j.cgh.2023.08.044

Background & Aims: Functional constipation is the most common of the disorders of gut-brain interaction, affecting approximately 12% of the world population. Although classically considered a chronic condition, many individuals experience shorter yet... Read More about Perceptions, definitions, and therapeutic interventions for occasional constipation: a ROME working group consensus document.