All Outputs (2)

Appendicectomy plus standard medical therapy versus standard medical therapy alone for maintenance of remission in ulcerative colitis (ACCURE): a pragmatic, open-label, international, randomised trial (2025)
Journal Article
Acherman, Y. I. Z., Arebi, N., Arthurs, E., Bemelman, W. A., van der Bilt, J. D. W., Braat, H., Brink, M. A., Brookes, M., Brown, J. P. Y., Brown, S. R., Buskens, C. J., Consten, E. C. J., Cooney, R., Crolla, R. M. P. H., Davies, R. J., Depla, A. C. T. M., D'Haens, G. R., Dijkgraaf, M. G. W., Doherty, G., van Duijvendijk, P., …van der Zanden, E. P. M. (2025). Appendicectomy plus standard medical therapy versus standard medical therapy alone for maintenance of remission in ulcerative colitis (ACCURE): a pragmatic, open-label, international, randomised trial. The Lancet Gastroenterology & Hepatology, 10(6), 550-561. https://doi.org/10.1016/S2468-1253%2825%2900026-3

Background
The appendix might have an immunomodulatory role in ulcerative colitis. Appendicectomy has been suggested as a potentially therapeutic intervention to maintain remission in ulcerative colitis. We aimed to evaluate the clinical effectivene... Read More about Appendicectomy plus standard medical therapy versus standard medical therapy alone for maintenance of remission in ulcerative colitis (ACCURE): a pragmatic, open-label, international, randomised trial.

Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study (2021)
Journal Article
Sebastian, S., Walker, G. J., Kennedy, N. A., Conley, T. E., Patel, K. V., Subramanian, S., Kent, A. J., Segal, J. P., Brookes, M. J., Bhala, N., Gonzalez, H. A., Hicks, L. C., Mehta, S. J., Lamb, C. A., Abdale, S., Abbasi, A., Abusrewil, A., Aghimien, P., Ahmed, S., Ali, A., …Zafar, M. (2021). Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study. The Lancet Gastroenterology & Hepatology, 6(4), 271-281. https://doi.org/10.1016/s2468-1253%2821%2900016-9

Background
There is a paucity of evidence to support safe and effective management of patients with acute severe ulcerative colitis during the COVID-19 pandemic. We sought to identify alterations to established conventional evidence-based management... Read More about Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study.