All Outputs (5)

STAT3 signaling enhances tissue expansion during postimplantation mouse development (2025)
Journal Article
Azami, T., Theeuwes, B., Ton, M.-L. N., Mansfield, W., Harland, L., Kinoshita, M., Gottgens, B., & Nichols, J. (2025). STAT3 signaling enhances tissue expansion during postimplantation mouse development. Cell Reports, 44(4), Article 115506. https://doi.org/10.1016/j.celrep.2025.115506

Signal transducer and activator of transcription (STAT)3 signaling has been studied extensively using mouse embryonic stem cells. Zygotic deletion of Stat3 enables embryo implantation, but thereafter, mutants resemble non-affected littermates from th... Read More about STAT3 signaling enhances tissue expansion during postimplantation mouse development.

Exploring aneuploidies in two-center isolated bovine embryonic stem cell lines: Implications for cultured meat production (2025)
Journal Article
Deelkens, C., De Vlieghere, E., Van Poucke, M., Kinoshita, M., Aalders, J., Thorrez, L., Devriendt, B., Van Soom, A., Peelman, L., Menten, B., De Schauwer, C., & van Hengel, J. (2025). Exploring aneuploidies in two-center isolated bovine embryonic stem cell lines: Implications for cultured meat production. Future Foods, 11, Article 100555. https://doi.org/10.1016/j.fufo.2025.100555

As the global population continues to grow, the demand for sustainable food production methods becomes increasingly critical. This study investigates the presence of chromosomal abnormalities in bovine embryonic stem cells (bESCs), which hold potenti... Read More about Exploring aneuploidies in two-center isolated bovine embryonic stem cell lines: Implications for cultured meat production.

Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species (2021)
Journal Article
Kinoshita, M., Kobayashi, T., Planells, B., Klisch, D., Spindlow, D., Masaki, H., Bornelöv, S., Stirparo, G. G., Matsunari, H., Uchikura, A., Lamas-Toranzo, I., Nichols, J., Nakauchi, H., Nagashima, H., Alberio, R., & Smith, A. (2021). Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species. Development, 148(23), Article dev199901. https://doi.org/10.1242/dev.199901

Despite four decades of effort, robust propagation of pluripotent stem cells from livestock animals remains challenging. The requirements for self-renewal are unclear and the relationship of cultured stem cells to pluripotent cells resident in the em... Read More about Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species.

Disabling de novo DNA methylation in embryonic stem cells allows an illegitimate fate trajectory (2021)
Journal Article
Kinoshita, M., Li, M. A., Barber, M., Mansfield, W., Dietmann, S., & Smith, A. (2021). Disabling de novo DNA methylation in embryonic stem cells allows an illegitimate fate trajectory. Proceedings of the National Academy of Sciences, 118(38), Article e2109475118. https://doi.org/10.1073/pnas.2109475118

Genome remethylation is essential for mammalian development but specific reasons are unclear. Here we examined embryonic stem (ES) cell fate in the absence of de novo DNA methyltransferases. We observed that ES cells deficient for both Dnmt3a and Dnm... Read More about Disabling de novo DNA methylation in embryonic stem cells allows an illegitimate fate trajectory.

Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency (2020)
Journal Article
Kinoshita, M., Barber, M., Mansfield, W., Cui, Y., Spindlow, D., Stirparo, G. G., Dietmann, S., Nichols, J., & Smith, A. (2021). Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency. Cell Stem Cell, 28(3), 453-471. https://doi.org/10.1016/j.stem.2020.11.005

Pluripotent cells emerge as a naive founder population in the blastocyst, acquire capacity for germline and soma formation, and then undergo lineage priming. Mouse embryonic stem cells (ESCs) and epiblast-derived stem cells (EpiSCs) represent the ini... Read More about Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency.