All Outputs (9)

Stochastic variational inference improves quantification of multiple timepoint arterial spin labelling perfusion MRI (2025)
Journal Article
Kirk, T. F., Kenyon, G. G., Craig, M. S., & Chappell, M. A. (2025). Stochastic variational inference improves quantification of multiple timepoint arterial spin labelling perfusion MRI. Frontiers in Neuroscience, 19, Article 1536752. https://doi.org/10.3389/fnins.2025.1536752

Multiple-timepoint arterial spin labelling MRI is a non-invasive imaging technique that permits measurement of both cerebral blood flow and arterial transit time, the latter of which is an emerging biomarker of interest for cerebrovascular health. Qu... Read More about Stochastic variational inference improves quantification of multiple timepoint arterial spin labelling perfusion MRI.

Arterial spin labelling perfusion MRI analysis for the Human Connectome Project Lifespan Ageing and Development studies (2025)
Journal Article
Kirk, T. F., McConnell, F. A. K., Toner, J., Craig, M. S., Carone, D., Li, X., Suzuki, Y., Coalson, T. S., Harms, M. P., Glasser, M. F., & Chappell, M. A. (2025). Arterial spin labelling perfusion MRI analysis for the Human Connectome Project Lifespan Ageing and Development studies. Imaging Neuroscience, 3, Article imag_a_00444. https://doi.org/10.1162/imag_a_00444

The Human Connectome Project Lifespan studies cover the Development (5-21) and Aging (36-100+) phases of life. Arterial spin labelling (ASL) was included in the imaging protocol, resulting in one of the largest datasets collected to-date of high spat... Read More about Arterial spin labelling perfusion MRI analysis for the Human Connectome Project Lifespan Ageing and Development studies.

Regional changes in cerebral perfusion with age when accounting for changes in gray-matter volume (2024)
Journal Article
Hu, J., Craig, M. S., Knight, S. P., De Looze, C., Meaney, J. F., Kenney, R. A., Chen, X., & Chappell, M. A. (2025). Regional changes in cerebral perfusion with age when accounting for changes in gray-matter volume. Magnetic Resonance in Medicine, 93(4), 1807-1820. https://doi.org/10.1002/mrm.30376

Purpose
One possible contributing factor for cerebral blood flow (CBF) decline in normal aging is the increase in partial volume effects due to brain atrophy, as cortical thinning can exacerbate the contamination of gray-matter (GM) voxels by other... Read More about Regional changes in cerebral perfusion with age when accounting for changes in gray-matter volume.

BASIL: A Toolbox for Perfusion Quantification using Arterial Spin Labelling (2023)
Journal Article
Chappell, M. A., Kirk, T. F., Craig, M. S., McConnell, F. A. K., Zhao, M. Y., MacIntosh, B. J., Okell, T. W., & Woolrich, M. W. (2023). BASIL: A Toolbox for Perfusion Quantification using Arterial Spin Labelling. Imaging Neuroscience, https://doi.org/10.1162/imag_a_00041

Arterial Spin Labelling (ASL) MRI is now an established non-invasive method to quantify cerebral blood flow and is increasingly being used in a variety of neuroimaging applications. With standard ASL acquisition protocols widely available, there is a... Read More about BASIL: A Toolbox for Perfusion Quantification using Arterial Spin Labelling.

A resource for development and comparison of multimodal brain 3T MRI harmonisation approaches (2023)
Journal Article
Warrington, S., Ntata, A., Mougin, O., Campbell, J., Torchi, A., Craig, M., Alfaro-Almagro, F., Miller, K. L., Morgan, P. S., Jenkinson, M., & Sotiropoulos, S. N. (2023). A resource for development and comparison of multimodal brain 3T MRI harmonisation approaches. Imaging Neuroscience, 1(2023), 1-27. https://doi.org/10.1162/imag_a_00042

Despite the huge potential of magnetic resonance imaging (MRI) in mapping and exploring the brain, MRI measures can often be limited in their consistency, reproducibility and accuracy which subsequently restricts their quantifiability. Nuisance nonbi... Read More about A resource for development and comparison of multimodal brain 3T MRI harmonisation approaches.

Validation of the estimation of the macrovascular contribution in multi‐timepoint arterial spin labeling MRI using a 2‐component kinetic model (2021)
Journal Article
Plas, M. C. E., Craig, M., Schmid, S., Chappell, M. A., & Osch, M. J. P. (2022). Validation of the estimation of the macrovascular contribution in multi‐timepoint arterial spin labeling MRI using a 2‐component kinetic model. Magnetic Resonance in Medicine, 87(1), 85-101. https://doi.org/10.1002/mrm.28960

Purpose
In this paper, the ability to quantify cerebral blood flow by arterial spin labeling (ASL) was studied by investigating the separation of the macrovascular and tissue component using a 2-component model. Underlying assumptions of this model,... Read More about Validation of the estimation of the macrovascular contribution in multi‐timepoint arterial spin labeling MRI using a 2‐component kinetic model.

Study Protocol: The Heart and Brain Study (2021)
Journal Article
Suri, S., Bulte, D., Chiesa, S. T., Ebmeier, K. P., Jezzard, P., Rieger, S. W., Pitt, J. E., Griffanti, L., Okell, T. W., Craig, M., Chappell, M. A., Blockley, N. P., Kivimäki, M., Singh-Manoux, A., Khir, A. W., Hughes, A. D., Deanfield, J. E., Jensen, D. E. A., Green, S. F., Sigutova, V., …Mackay, C. E. (2021). Study Protocol: The Heart and Brain Study. Frontiers in Physiology, 12, Article 643725. https://doi.org/10.3389/fphys.2021.643725

Background: It is well-established that what is good for the heart is good for the brain. Vascular factors such as hypertension, diabetes, and high cholesterol, and genetic factors such as the apolipoprotein E4 allele increase the risk of developing... Read More about Study Protocol: The Heart and Brain Study.

Does the magnetization transfer effect bias chemical exchange saturation transfer effects? Quantifying chemical exchange saturation transfer in the presence of magnetization transfer (2020)
Journal Article
Smith, A. K., Ray, K. J., Larkin, J. R., Craig, M., Smith, S. A., & Chappell, M. A. (2020). Does the magnetization transfer effect bias chemical exchange saturation transfer effects? Quantifying chemical exchange saturation transfer in the presence of magnetization transfer. Magnetic Resonance in Medicine, 84(3), 1359-1375. https://doi.org/10.1002/mrm.28212

Quantitative blood flow measurement in rat brain with multiphase arterial spin labelling magnetic resonance imaging (2018)
Journal Article
Larkin, J. R., Simard, M. A., Khrapitchev, A. A., Meakin, J. A., Okell, T. W., Craig, M., Ray, K. J., Jezzard, P., Chappell, M. A., & Sibson, N. R. (2019). Quantitative blood flow measurement in rat brain with multiphase arterial spin labelling magnetic resonance imaging. Journal of Cerebral Blood Flow and Metabolism, 39(8), 1557-1569. https://doi.org/10.1177/0271678x18756218