All Outputs (6)

Potential role for pyruvate kinase M2 in the regulation of murine cardiac glycolytic flux during in vivo chronic hypoxia (2021)
Journal Article
Handzlik, M. K., Tooth, D. J., Constantin-Teodosiu, D., Greenhaff, P. L., & Cole, M. A. (2021). Potential role for pyruvate kinase M2 in the regulation of murine cardiac glycolytic flux during in vivo chronic hypoxia. Bioscience Reports, 41(6), Article BSR20203170. https://doi.org/10.1042/bsr20203170

Carbohydrate metabolism in heart failure shares similarities to that following hypoxic exposure, and is thought to maintain energy homeostasis in the face of reduced O2 availability. As part of these in vivo adaptations during sustained hypoxia, the... Read More about Potential role for pyruvate kinase M2 in the regulation of murine cardiac glycolytic flux during in vivo chronic hypoxia.

Increasing cardiac pyruvate dehydrogenase flux during chronic hypoxia improves acute hypoxic tolerance (2018)
Journal Article
Handzlik, M., Constantin-Teodosiu, D., Greenhaff, P. L., & Cole, M. (2018). Increasing cardiac pyruvate dehydrogenase flux during chronic hypoxia improves acute hypoxic tolerance. Journal of Physiology, 596(15), 3357-3369. https://doi.org/10.1113/JP275357

The pattern of metabolic reprogramming in chronic hypoxia shares similarities with that following myocardial infarction or hypertrophy, however the response of the chronically hypoxic heart to subsequent acute injury, and the role of metabolism is no... Read More about Increasing cardiac pyruvate dehydrogenase flux during chronic hypoxia improves acute hypoxic tolerance.

A novel ketone diet enhances physical and cognitive performance (2016)
Journal Article
Murray, A. J., Knight, N. S., Cole, M. A., Cochlin, L. E., Carter, E., Tchabanenko, K., Pichulik, T., Gulston, M. K., Atherton, H. J., Schroeder, M. A., Deacon, R. M. J., Kashiwaya, Y., King, M. T., Pawlosky, R., Rawlins, J. N. P., Tyler, D. J., Griffin, J. L., Robertson, J., Veech, R. L., & Clarke, K. (2016). A novel ketone diet enhances physical and cognitive performance. FASEB Journal, 30(12), 4021-4032. https://doi.org/10.1096/fj.201600773R

Ketone bodies are the most energy efficient fuel, yielding more ATP per mole of substrate than pyruvate and increasing the free energy released from ATP hydrolysis. Elevation of circulating ketones via high-fat, low-carbohydrate diets has been used f... Read More about A novel ketone diet enhances physical and cognitive performance.

The von Hippel-Lindau Chuvash mutation in mice alters cardiac substrate and high energy phosphate metabolism (2016)
Journal Article
Slingo, M., Cole, M., Carr, C., Curtis, M. K., Dodd, M., Giles, L., …Robbins, P. A. (in press). The von Hippel-Lindau Chuvash mutation in mice alters cardiac substrate and high energy phosphate metabolism. AJP - Heart and Circulatory Physiology, https://doi.org/10.1152/ajpheart.00912.2015

Hypoxia-inducible factor (HIF) appears to function as a global master regulator of cellular and systemic responses to hypoxia. HIF-pathway manipulation is of therapeutic interest, however global, systemic upregulation of HIF may have as yet unknown e... Read More about The von Hippel-Lindau Chuvash mutation in mice alters cardiac substrate and high energy phosphate metabolism.

On the pivotal role of PPARa in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury (2016)
Journal Article
Cole, M., Abd Jamil, A. H., Heather, L. C., Murray, A. J., Sutton, E. R., Slingo, M., …Clarke, K. (2016). On the pivotal role of PPARa in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury. FASEB Journal, 30(8), 2684-2697. https://doi.org/10.1096/fj.201500094R

The role of peroxisome proliferator activated alpha (PPARα) -mediated metabolic remodeling in cardiac adaptation to hypoxia has yet to be defined. Here, mice were housed in hypoxia for 3 weeks before in vivo contractile function was measured using c... Read More about On the pivotal role of PPARa in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury.

Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation (2015)
Journal Article
Mansor, L. S., Mehta, K., Aksentijevic, D., Carr, C. A., Lund, T., Cole, M. A., …Heather, L. C. (2016). Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation. Journal of Physiology, 594(2), 307-320. https://doi.org/10.1113/JP271242

Hypoxia activates the hypoxia-inducible factor (HIF), promoting glycolysis and suppressing mitochondrial respiration. In the type 2 diabetic heart, glycolysis is suppressed whereas fatty acid metabolism is promoted. The diabetic heart experiences chr... Read More about Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation.