The REFRACT trial: Implementation of Bayesian power priors in a randomised, sequential phase II adaptive platform trial
(2025)
Journal Article
Gaskell, C., Linton, K., Bishton, M., McIlroy, G., Lax, S., Fox, S., Hopkins, L., Collings, R., Rhodes, M., Seale, T., & Jackson, A. (2025). The REFRACT trial: Implementation of Bayesian power priors in a randomised, sequential phase II adaptive platform trial. BMC Medical Research Methodology, 25, Article 121. https://doi.org/10.1186/s12874-025-02575-5
Background: REFRACT is a randomised trial aimed at rapidly evaluating multiple novel therapies against standard treatment for relapsed or refractory follicular lymphoma (rrFL) using a minimal number of patients. To this end, we designed a prospective... Read More about The REFRACT trial: Implementation of Bayesian power priors in a randomised, sequential phase II adaptive platform trial.